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Int J Sports Med 2022; 43(11): 921-930
DOI: 10.1055/a-1790-7982
Review

Leukocyte-rich and Leukocyte-poor Platelet-rich Plasma in Rotator Cuff Repair: A Meta-analysis

Yundong Peng‡
1   College of Health Science, Wuhan Sports University, Wuhan, China
,
Wang Guanglan‡
1   College of Health Science, Wuhan Sports University, Wuhan, China
,
Shaohui Jia
1   College of Health Science, Wuhan Sports University, Wuhan, China
,
Cheng Zheng
2   Department of Sports Medicine, Affiliated Hospital, Wuhan Sports University, Wuhan, China
› Author Affiliations Funding This work was supported by the Hubei Provincial Natural Science Foundation of China (No. 2019CFB397), Donghu Scholar Program of Wuhan Sports University and Research Fund for Young Teachers of Wuhan Sports University (No. 20Z01), Young and Middle-Aged Scientific Research and Innovation Team Project of Wuhan Sports University (No. 21KT14)
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Abstract

To systematically review of randomized controlled trials (RCTs) to compared the effects of leukocyte-rich and leukocyte-poor platelet-rich plasma in arthroscopic rotator cuff repair. Two independent reviewers comprehensively searched PubMed, Embase, and Cochrane library databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Comparison of leukocyte-rich platelet-rich plasma or leukocyte-poor platelet-rich plasma in rotator cuff repair in a level I RCTs. Methodological quality assessment was carried out using Cochrane Review Manager 5.3 software. P<0.05 was considered statistically significant. Nine RCTs with 540 patients were included in this review. Meta-analysis showed that leukocyte-poor platelet-rich plasma in significantly reduced retear rate in rotator cuff repair [RR=0.56 95% CI (0.42, 0.75); P<0.05), and in clinical results, the constant score [MD=3.67, 95% CI (1.62, 5.73); P=0.0005], UCLA score [MD=1.60, 95% CI (0.79, 2.42); P=0.0001], ASES score [MD=2.16, 95% CI (0.12, 4.20); P=0.04] were significantly improved. There was a significant result in favor of PRP for the Constant score [MD=−1.24, 95% CI (−1.50, −0.99); P<0.00001], while SST scores were not significantly different among all groups [MD=0.21, 95% CI (−0.21, 0.64); P=0.32]. In conclusion, leukocyte-poor platelet-rich plasma can improved the clinical function and reduced retear rate in arthroscopic rotator cuff repair. In contrast, the efficacy of leukocyte-rich platelet-rich plasma was not significantly improved with the exception of VAS score.

Key words

leukocyte-rich platelet-rich plasma - leukocyte-poor platelet-rich plasma - rotator cuff injury - biological augmentation - meta analysis


Publication History

Received: 13 July 2021

Accepted: 03 March 2022

Accepted Manuscript online:
07 March 2022

Article published online:
06 May 2022

© 2022. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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