Synthesis 2022; 54(17): 3845-3857
DOI: 10.1055/a-1742-2005
special topic
Special Issue in memory of Prof. Ferenc Fülöp

Electrocyclization and Unexpected Reactions of Non-Stabilized α,β:γ,δ-Unsaturated Azomethine Ylides: Experimental and Theoretical Studies

István G. Molnár
a   Servier Research Institute of Medicinal Chemistry, 7 Záhony utca., 1031 Budapest, Hungary
,
Zoltán Mucsi
b   Femtonics Research Institute, 59 Tűzoltó utca, 1094 Budapest, Hungary
c   Institute of Chemistry, Faculty of Materials Science and Engineering, University of Miskolc, 3515 Miskolc, Hungary
,
Ervin Kovács
b   Femtonics Research Institute, 59 Tűzoltó utca, 1094 Budapest, Hungary
d   Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 2 Magyar tudósok körútja, 1117 Budapest, Hungary
,
Miklós Nyerges
a   Servier Research Institute of Medicinal Chemistry, 7 Záhony utca., 1031 Budapest, Hungary
› Author Affiliations
This project was supported by National Research, Development and Innovation Fund of Hungary, financed under the (OTKA PD128612) funding scheme. The authors are grateful to the Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/799/21/7), the ÚNKP-21-5 new National Excellence Program, NVKP-16 (1-2016-0043), KFI-16 (1-2016-0177), KFI-18 (00097) and VKE-18 (00032) of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund for financial support.


Abstract

Versatile, two-step syntheses of dihydrodibenzo[c,e]azepines, carbazole derivatives, and other alkaloid-type drug-like scaffolds by in situ generated azomethine ylide-induced intramolecular electrocyclization reaction from commercially available materials are presented. The reaction mechanisms of transition-metal-free carbon–carbon bond formation and the role of the kinetic control, resulting in the good regioselectivity, were confirmed by theoretical calculations.

Supporting Information



Publication History

Received: 25 November 2021

Accepted after revision: 17 January 2022

Accepted Manuscript online:
17 January 2022

Article published online:
24 March 2022

© 2022. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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