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Tierarztl Prax Ausg K Kleintiere Heimtiere 2022; 50(01): 46-56
DOI: 10.1055/a-1696-3847
Kasuistik

Akzidentelle Colchicinintoxikation bei einem Mischlingshund

Accidental colchicine intoxication in a cross-breed dog
Miriam Keiner
Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen, Gießen
,
Vanessa Dreller
Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen, Gießen
,
Isabelle Klemm
Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen, Gießen
,
Hendrik Lehmann
Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen, Gießen
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Zusammenfassung

Eine 2 Jahre alte Mischlingshündin wurde aufgrund von akutem Erbrechen und zunehmender Apathie vorgestellt. Die Hündin hatte etwa 1–3 Stunden vor Vorstellung das Gichtmittel ihres Besitzers (0,35 mg/kg Colchicin) aufgenommen.

Während des stationären Aufenthaltes durchlief die Hündin alle beschriebenen Stadien (gastrointestinale Phase, Multiorganphase, Erholungsphase) einer Colchicinvergiftung, wobei der Verlauf durch das Vorliegen eines Multiorgandysfunktionssyndroms (MODS) und zahlreicher negativ prognostischer Faktoren verkompliziert wurde.

Diese Kasuistik beschreibt die klinischen und labordiagnostischen Auswirkungen einer Colchicinvergiftung bei einem Hund und stellt die erste erfolgreiche Behandlung einer solchen in Europa dar.

Abstract

A 2-year old cross-breed dog presented due to acute vomiting and progressive lethargy following ingestion of the owner’s anti-gout medication (colchicine, 0.35 mg/kg) 1–3 hours prior to presentation.

The dog developed signs of all 3 stages of colchicine poisoning (gastrointestinal phase, multi-organ phase, recovery phase) and the clinical course was complicated by the presence of multi-organ dysfunction syndrome (MODS) and numerous negative prognostic factors.

This case report describes the clinical and laboratory effects of colchicine poisoning and represents the first successful treatment of an accidental colchicine ingestion in a dog in Europe.

Schlüsselwörter

Hund - Colchicin - Vergiftung - Multiorgandysfunktionssyndrom (MODS) - intravenöse Lipidtherapie

Key words

Dog - colchicine - toxicosis - multi-organ dysfunction syndrome (MODS) - intravenous lipid therapy


Publication History

Received: 26 September 2020

Accepted: 21 January 2021

Article published online:
02 March 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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