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Drug Res (Stuttg) 2022; 72(01): 41-46
DOI: 10.1055/a-1589-5395
Original Article

Evaluation of Anti-inflammatory and Antioxidant Effects of Sumatriptan on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Ahmad Reza Dehpour‡
1   Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2   Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Hasan Yousefi-Manesh‡
1   Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2   Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad Sheibani
3   Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Mohammad Amin Sadeghi
1   Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2   Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Sara Hemmati
1   Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2   Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Tayebeh Noori
4   Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
,
Samira Shirooie
4   Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
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Abstract

The liver detoxifies and metabolizes many drugs and xenobiotics which may cause hepatotoxicity due to some toxic agents. Carbon tetrachloride (CCl4) is metabolized in cytochrome P450 and its reactive radical metabolites cause lipid peroxidation, cellular injury, and apoptosis. Sumatriptan (SUM), 5-HT1B/1D receptor agonist, had anti-inflammatory and anti-oxidant effects. In this research the effect of SUM pre-treatment against CCl4-induced hepatotoxicity was examined. Adult rats received SUM (0.1, 0.3 and 1 mg/kg; i.p.) for 3 consecutive days before CCl4 (2 ml/kg; i.p. on the 3rd day). The aminotransferases serum levels, tissue levels of anti-oxidant and pro-inflammatory markers and histopathological examination were evaluated. SUM (0.3 mg/kg) prevented significantly the elevation of aminotransferases versus the control group (CCl4 group) (P<0.0001) and also, reversed meaningfully the changes of the MPO, MDA, SOD and CAT, IL-1β and TNF-α levels. Additionally, CCl4-intoxication resulted to the disruption of lobular and cellular structures and inflammation in histopathological evaluation which is prevented by SUM (0.3 mg/kg). These data revealed that SUM (0.3 mg/kg), but no at doses 0.1 and 1 mg/kg, decreases the hepatotoxicity of induced by CCl4 in rats.

Key words

CCl4 - Hepatotoxicity - Sumatriptan - Inflammation - Oxidative stress


Publication History

Received: 30 April 2021

Accepted: 09 August 2021

Article published online:
09 September 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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