Dtsch Med Wochenschr 2022; 147(16): 1047-1055
DOI: 10.1055/a-1562-7039
Dossier

Follow up-Management nach interventionellem Aortenklappenersatz

Follow up Management after Transcatheter Aortic Valve Implantation
Vera Fortmeier
,
Tanja K. Rudolph

Eine engmaschige Nachbeobachtung von Patienten mit kathetergestütztem Aortenklappenersatz (TAVI) kann Komplikationen verhindern, die häufig durch Komorbiditäten ausgelöst werden. Im Folgenden sollen neben Empfehlungen zu klinischen, laborchemischen, elektro- und echokardiografischen Verlaufskontrollen auch die Endokarditis-Prophylaxe beleuchtet werden. Zentraler Aspekt im postinterventionellen TAVI-Management ist außerdem das antithrombotische Regime, das hier schwerpunktmäßig erläutert werden soll.

Abstract

Transcatheter aortic valve implantation (TAVI) has emerged as the gold standard therapy for patients with severe aortic stenosis with a high operative risk or older than 75 years. As these patients usually exhibit several comorbidities, not only the preinterventional and periinterventional management are of interest, but also the postinterventional care plays an incremental role in order to prevent short and long term complications having an enormous influence on morbidity and mortality. Therefore, a close clinical observation by the primary care physician and primary cardiologist is essential for the patient’s outcome. After discharge the first follow up examination should be carried out 1 to 3 months after TAVI, the second one 6 months after TAVI, afterwards once a year. A detailed anamnesis especially regarding symptoms such as dyspnoea, anginal complaints and vertigo should be performed. Additionally, an electrocardiogram is recommended to detect conduction disturbances. An echocardiography with the focus on prosthetic valve function, paravalvular leckage, left ventricular function and possible indications for endocarditis is essential. Next to the endocarditis prophylaxis before specific dental procedures, the antithrombotic regimen plays a key role in the follow up management after TAVI. On the one hand, antithrombotic therapy reduces thromboembolic complications, on the other hand they might increase the bleeding risk. An optimal antithrombotic treatment strategy challenges clinicians as patient-specific risk factors and comorbidities (e. g., age, atrial fibrillation, coronary artery disease) must be considered and current data still leave some uncertainties.



Publication History

Article published online:
15 August 2022

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  • Literatur

  • 1 Otto CM, Nishimura RA, Bonow RO. et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2021; 143: e35-e71 DOI: 10.1161/CIR.0000000000000923.
  • 2 Vahanian A, Beyersdorf F, Praz F. et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2021; ehab395 DOI: 10.1093/eurheartj/ehab395.
  • 3 Hochholzer W, Nührenberg T, Flierl U. et al. Antithrombotische Therapie nach strukturellen kardialen Interventionen: Empfehlung der Arbeitsgruppe Kardiovaskuläre Hämostase und Antithrombotische Therapie (AG19) der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK) in Zusammenarbeit mit der Arbeitsgruppe Interventionelle Kardiologie (AG6) – AGIK und der Arbeitsgruppe Klinische Pharmakologie (AG22) der DGK. Kardiologe 2021; 15: 57-70 DOI: 10.1007/s12181-020-00441-w.
  • 4 Capodanno D, Collet J-P, Dangas G. et al. Antithrombotic Therapy After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv 2021; 14: 1688-1703 DOI: 10.1016/j.jcin.2021.06.020.
  • 5 Rodés-Cabau J, Masson J-B, Welsh RC. et al. Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve. JACC Cardiovasc Interv 2017; 10: 1357-1365 DOI: 10.1016/j.jcin.2017.04.014.
  • 6 Brouwer J, Nijenhuis VJ, Delewi R. et al. Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation. N Engl J Med 2020; 383: 1447-1457 DOI: 10.1056/NEJMoa2017815.
  • 7 Dangas GD, Tijssen JGP, Wöhrle J. et al. A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement. N Engl J Med 2020; 382: 120-129 DOI: 10.1056/NEJMoa1911425.
  • 8 Collet J-P, Berti S, Cequier A. et al. Oral anti-Xa anticoagulation after trans-aortic valve implantation for aortic stenosis: The randomized ATLANTIS trial. Am Heart J 2018; 200: 44-50 DOI: 10.1016/j.ahj.2018.03.008.
  • 9 ten Berg J, Sibbing D, Rocca B. et al. Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease. Eur Heart J 2021; 42: 2265-2269 DOI: 10.1093/eurheartj/ehab196.
  • 10 Overtchouk P, Guedeney P, Rouanet S. et al. Long-Term Mortality and Early Valve Dysfunction According to Anticoagulation Use. J Am Coll Cardiol 2019; 73: 13-21 DOI: 10.1016/j.jacc.2018.08.1045.
  • 11 Nijenhuis VJ, Brouwer J, Delewi R. et al. Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation. N Engl J Med 2020; 382: 1696-1707 DOI: 10.1056/NEJMoa1915152.
  • 12 Kawashima H, Watanabe Y, Hioki H. et al. Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients With Atrial Fibrillation After TAVR. JACC Cardiovasc Interv 2020; 13: 2587-2597 DOI: 10.1016/j.jcin.2020.09.013.
  • 13 Jochheim D, Barbanti M, Capretti G. et al. Oral Anticoagulant Type and Outcomes After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv 2019; 12: 1566-1576 DOI: 10.1016/j.jcin.2019.03.003.
  • 14 Seeger J, Gonska B, Rodewald C. et al. Apixaban in Patients With Atrial Fibrillation After Transfemoral Aortic Valve Replacement. JACC Cardiovasc Interv 2017; 10: 66-74 DOI: 10.1016/j.jcin.2016.10.023.
  • 15 Van Mieghem NM, Unverdorben M, Hengstenberg C. et al. Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR. N Engl J Med 2021; 385: 2150-2160 DOI: 10.1056/NEJMoa2111016.
  • 16 Kato ET, Giugliano RP, Ruff CT. et al. Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF–TIMI 48 Trial. J Am Heart Assoc 2016; 5: e003432 DOI: 10.1161/JAHA.116.003432.
  • 17 Franzone A, Pilgrim T, Haynes AG. et al. Transcatheter aortic valve thrombosis: incidence, clinical presentation and long-term outcomes. Eur Heart J – Cardiovasc Imaging 2018; 19: 398-404 DOI: 10.1093/ehjci/jex181.
  • 18 Hansson NC, Grove EL, Andersen HR. et al. Transcatheter Aortic Valve Thrombosis. J Am Coll Cardiol 2016; 68: 2059-2069 DOI: 10.1016/j.jacc.2016.08.010.
  • 19 Bogyi M, Schernthaner RE, Loewe C. et al. Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv 2021; 14: 2643-2656 DOI: 10.1016/j.jcin.2021.09.019.
  • 20 Rosseel L, De Backer O, Søndergaard L. Clinical Valve Thrombosis and Subclinical Leaflet Thrombosis Following Transcatheter Aortic Valve Replacement: Is There a Need for a Patient-Tailored Antithrombotic Therapy?. Front Cardiovasc Med 2019; 6: 44 DOI: 10.3389/fcvm.2019.00044.