Manganese-Catalyzed C(sp²)–H Addition to Polar Unsaturated Bonds

Abstract

Transition-metal-catalyzed nucleophilic C–H addition of hydrocarbons to polar unsaturated bonds could intrinsically avoid prefunctionalization of substrates and formation of waste byproducts, thus featuring high step- and atom-economy. As the third most abundant transition metal, manganese-catalyzed C–H addition to polar unsaturated bonds remains challenging, partially due to the difficulty in building a closed catalytic cycle of manganese. In the past few years, we have developed manganese catalysis to enable the sp²-hydrid C–H addition to polar unsaturated bonds (e.g., imines, aldehydes, nitriles), which will be discussed in this personal account.

1 Introduction

2 Mn-Catalyzed N-Directed C(sp²)–H Addition to Polar Unsaturated Bonds

3 Mn-Catalyzed O-Directed C(sp²)–H Addition to Polar Unsaturated Bonds

4 Conclusion

Key words

manganese - catalysis - C–H activation - polar unsaturated bonds - organic synthesis

Publication History

Received: 23 February 2021

Accepted after revision: 27 March 2021

Accepted Manuscript online:
27 March 2021

Article published online:
28 April 2021

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