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Horm Metab Res 2021; 53(02): 105-111
DOI: 10.1055/a-1342-7098
Endocrine Care

Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population

Dongdong Zhang
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
,
Cheng Cheng
2   Department of Epidemiology and Health Statistics, Zhengzhou University, Zhengzhou, Henan, China
,
Yan Wang
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
,
Yuan Xue
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
,
Yiming Liu
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
,
Wenjie Li
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
,
Xing Li
1   Department of Nutrition and Food Hygiene, Zhengzhou University, Zhengzhou, Henan, China
› Author Affiliations Funding: This work was supported by the National Nature Science Foundation of China (grants numbers 81872626 and 81573151); Chinese Nutrition Society - Bright Moon Seaweed Group Nutrition and Health Research Fund (grants numbers CNS-BMSG2020A63); Chinese Nutrition Society - Zhendong National Physical Fitness and Health Research Fund (grants numbers CNS-ZD2019066) and the Science and Technology Foundation for Innovation Talent of Henan Province (grants number 154200510010). All the funders had no role in the design, analysis or writing of this article.
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Abstract

There is a paucity of data on the relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and cardiometabolic biomarkers in the Chinese population. To comprehensively and quantitatively examine the association of 25(OH)D and cardiometabolic traits, we conducted a cross-sectional study in the Chinese rural population. Serum 25(OH)D and eight cardiometabolic biomarkers were measured in 1714 individuals from Henan province, China. Scatter plot was used to visualize the distribution and correlation of 25(OH)D and cardiometabolic indicators. Moreover, multivariate linear regressions and restricted cubic spline (RCS) functions were performed to examine the quantitative association between the serum 25(OH)D and cardiometabolic parameters. The median serum 25(OH)D level was 19.94 ng/ml in all participants, with an estimated 50.12% presenting vitamin D deficiency. Serum 25(OH)D level showed significantly modest association with cardiometabolic parameters (p<0.05) except for diastolic blood pressure (r=0.03, p=0.22). Multiple linear regression models showed that 25(OH)D concentration was positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with low-density lipoprotein cholesterol (LDL-C) and fasting serum glucose (GLU). The results of restricted cubic spline models indicated a positively linear association of 25(OH)D with HDL-C (p for overall<0.001, p for nonlinearity=0.191) and a negatively linear association with GLU (p for overall=0.024, p for nonlinearity=0.095). Overall, vitamin D deficiency was very common among Chinese rural population living near the 34 degrees north latitude. Besides, there were significant association between 25(OH)D concentrations and cardiometabolic biomarkers including HDL-C and GLU levels. Future longitudinal studies and randomized trials are warranted to clarify the causal relationship.

Key words

vitamin D deficiency - 25(OH)D - lipid - blood glucose

Supplementary Material



Publication History

Received: 19 March 2020

Accepted after revision: 17 December 2020

Article published online:
29 January 2021

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