Senologie - Zeitschrift für Mammadiagnostik und -therapie 2021; 18(02): 121-123
DOI: 10.1055/a-1327-6432
Aktuell diskutiert

Empfehlungen der Österreichischen Gesellschaft für Senologie zur Diagnostik und Therapie des duktalen Karzinoms in situ (= DCIS)

Michael Stierer
1   PK Döbling, Brustzentrum Wien
,
Angelika Reiner
2   Pathologisch-bakteriologisches Institut, Klinikum Donaustadt, Wien
,
Florian Fitzal
3   Universitätsklinik für Chirurgie, Medizinische Universität Wien/AKH, Comprehensive Cancer Center (CCC)
› Author Affiliations

Bildgebende Diagnostik

  1. Bestimmung der Ausdehnung der Läsion durch digitale Mammografieverfahren

  2. Ultraschall nur bei assoziierter Herdläsion und/oder Architekturstörung

  3. Präoperative MRT: a) bei bioptisch verifiziertem DCIS G2, 3 bei dichter Brust (ACR 3 und 4)

    • bei Verdacht auf Multizentrizität und Multifokalität [1].

  4. Clipmarkierung nach jeder Biopsie obligat!
    Vakuumbiopsie oder Corebiopsie (nur bei soliden Läsionen) [2] [3]

  5. Präoperative, bildgesteuerte Hakenmarkierung. Bei großen Läsionen (≥ 4 cm) und quardrantenüberragenden Läsionen Markierung der Tumorränder mit Haken an bis zu 3 Stellen empfohlen. Bildgebende Dokumentation der Lage der Haken

  6. Präparatradiografie zum Nachweis der kompletten Exzision von Mikroverkalkungen [4] – unmittelbare Nachexzision bei sehr knappem oder involviertem Schnittrand eventuell in Zusammenschau mit einem möglichen Gefrierschnitt vom verdächtigen Schnittrand

  7. Postoperative Kontrollmammografie bei Schnittrand ≤ 2 mm und ausgedehntem Mikrokalk – Verdacht auf Residualkalk (4 bis 6 Wochen postoperativ, Kompression der Brust bereits möglich) [5] [6].
    Postoperative MRT bei Schnittrand ≤ 2 mm und ausgedehntem non-mass enhancement im Rahmen eines präoperativen MRT (Verdacht auf Residualläsion)

  8. Jährliche Kontrollmammografie zum Ausschluss von Rezidiven und kontralateralem Karzinom.



Publication History

Article published online:
01 June 2021

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  • Literatur

  • 1 Clauser P, Mann R, Athanasiou A. et al. A Survey by the European society of Breast Imaging on the Utilisation of Breast MRI in Clinical Practice. Eur Radiol 2018; 28 (05) 1909-1918
  • 2 Burbank F. Stereotactic breast biopsy of atypical ductal hyperplasia and ductal carcinoma in situ lesions: improved accuracy with directional, vaccum-assisted biopsy. Radiology 1997; 202: 843-847
  • 3 Lee CH, Carter D, Philpotts LE. et al. Ductal carcinoma in situ diagnosed with stereotactic core needle biopsy: can invasion be predicted?. Radiology 2000; 217: 466-470
  • 4 Morrow M, Strom EA, Bassett LW. et al. Standard for the management of ductal carcinoma in situ of the breast (DCIS). CA Cancer J Clin 2002; 52: 256-276
  • 5 Runowicz CD, Leach CR, Henry NL. et al. American Cancer Society/American Society of Clinical Oncology breast cancer suvivorship care guideline. J Clin Oncol 2016; 34 (06) 611-635
  • 6 NCCN Guidelines Breast Cancer Version 2020. www.nccn.org
  • 7 Hanna WM, Parra-Herran C, Lu Fi. et al. Ductal carcinoma in situ of the breast: an update for the pathologist in the era of individualized risk assessment and tailored therapies. Mod Pathol 2019; 32 (07) 896-915
  • 8 Lester SC, Bose S, Chen Y. et al. Protocol for the Examination of Specimens from Patients with Ductal Carcinoma in situ of the Breast. Arch Pathol Lab Med 2009; 133: 15-25
  • 9 Netter E, Troufléau P, Stinès J. [Ductal carcinoma in situ of the breast: role of imaging]. J Radiol 1998; 79: 651-658
  • 10 Morrow M, Van Zee KJ, Solin LJ. et al. Society of Surgical Oncology – American Society for Radiation Oncology – American Society of Clinical Oncology Consensus Guideline on Margins for Breast – Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ. J Clin Oncol 2016; 34 (33) 4040-4046
  • 11 Galimberti V, Vicini E, Corso G. et al. Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindication. Breast 2017; 34 (Suppl. 01) S82-S84
  • 12 Mabry H, Giuliano AE, Silverstein MJ. What is the value of axillary dissection or sentinel node biopsy in patients with ductal carcinoma in situ?. Am J Surg 2006; 192: 455-457
  • 13 Hannoun-Levi JM, Resch A, Gal J. et al. Accelerated partial breast irradiation with interstitial brachytherapy as second conservative treatment for ipsilateral breast tumor recurrence: Multicentric study of the GEC-ESTRO Breast Cancer Working Group. Radiother Oncol 2013; 8 (02) 226-231
  • 14 Walstra CJ, Schipper RJ, Poodt IG. et al. Repeat breast-conserving therapy for ipsilateral breast cancer recurrence: A systematic review. Eur J Surg Oncol 2019; 45 (08) 1317-1327
  • 15 Wöckel A, Fest J, Stüber T. et al. Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) – Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer Geburtshilfe Frauenheilkd. 2018 78. 1056-1088
  • 16 Souchon R, Sautter-Bihl ML, Sedlmayer F. et al. DEGRO practical guidelines: radiotherapy of breast cancer II: radiotherapy of non-invasive neoplasia of the breast. Strahlenther Onkol 2014; 190 (01) 8-16
  • 17 McCormick B, Winter K, Hudis C. et al. RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation. J Clin Oncol 2015; 33: 709-15
  • 18 Wehner P, Lagios MD, Silverstein MJ. DCIS treated with excision alone using the National Comprehensive Cancer Network (NCCN) guidelines. Ann Surg Oncol 2013; 20: 3175-3179
  • 19 Cardoso F, Kyriakides S, Ohno F. et al. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019; 30 (08) 1194-1220
  • 20 Burstein HJ, Curigliano G, Loibl S. et al. Estimating the Benefits of Therapy for Early Stage Breast Cancer. The St. Gallen International Consensus Guidelines for the Primary Therapy of Early Breast Cancer 2019. Ann Oncol 2019; 30 (10) 1541-1557
  • 21 AGO Guidelines breast version 2020.10. www.ago-online.de
  • 22 Vale LF, Agarwal S, Bickel KF. et al. Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials. Breast Cancer Res Treat 2017; 162 (03) 409-417
  • 23 Cante D, Franco P, Sciacero P. et al. Hypofractionation and concomitant boost to deliver adjuvant whole-breast radiation in ductal carcinoma in situ (DCIS): a subgroup analysis of a prospective case series. Med Oncol 2014; 31: 838
  • 24 Nilsson C, Valachis A. The role of boost and hypofractionation as adjuvant radiotherapy in patients with DCIS: a meta-analysis of observational studies. Radiother Oncol 2015; 114: 50-55
  • 25 Staley H, Mc Callum I, Bruce J. Postoperative tamoxifen for ductal carcinoma in situ: A systematic review and metaanalysis. The Breast 2014; 23 (05) 546-551
  • 26 Forbes JF, Sestak I, Howell A. et al. Anastrozole versus Tamoxifen for the prevention of loco-regional and contralateral breast cancer in postmenopausal women with locally excised Ductal Carcinoma in Situ (IBIS-II DCIS): A double blind randomized controlled trial. Lancet 2016; 387: 866-873
  • 27 DeCensi A, Puntoni M, Guerrieri-Gonzaga A. et al. Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia. J Clin Oncol 2019; 37 (19) 1629-1637