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Int J Sports Med 2021; 42(08): 749-759
DOI: 10.1055/a-1309-2037
Clinical Sciences

Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Maria Elizabeth Pereira Passos
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
2   Department of Laboratory Medicine, Universidade Federal de São Paulo, Sao Paulo, Brazil
,
Leandro Borges
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Laiane Cristina dos Santos-Oliveira
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Amanda Lins Alecrim-Zeza
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Tiago Bertola Lobato
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Heloisa Helena de Oliveira
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Cesar Miguel Momesso Santos
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Vinicius Leonardo Sousa Diniz
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Patrícia Nancy Iser-Bem
,
Richelieau Manoel
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Gilson Masahiro Murata
3   Department of Medical Clinic, Sao Paulo University Faculty of Medicine, Sao Paulo, Brazil
,
Sandro Massao Hirabara
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Rui Curi
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
4   Butantan Institute, Sao Paulo, Brazil
,
Tania Cristina Pithon-Curi
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Elaine Hatanaka
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
Renata Gorjao
1   Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
› Author Affiliations Funding: This study was supported by the Cruzeiro do Sul University, Sao Paulo State Research Foundation (FAPESP, process No. 2014/21185-1 and 2018/07283-1), Coordination for the Improvement of Higher-Level Personnel (CAPES), and the National Council for Scientific and Technological Development (CNPq).
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Abstract

This study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles.

Key words

T-regulatory cells - moderate physical exercise - interleukin-10


Publication History

Received: 14 July 2020

Accepted: 02 November 2020

Article published online:
15 December 2020

© 2020. Thieme. All rights reserved.

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