Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

Abstract

Background Hematological parameters have been investigated as being indicative of increased inflammatory response in morbidity of very preterm infants. This study aims to determine whether the hematologic parameters and ratios of preterms can be an indicative risk factor for the development of retinopathy of prematurity (ROP).

Materials-Methods This retrospective cohort study examined newborns born before 32 weeks. Twenty-three patients treated with the diagnosis of ROP were included in the patient group. The control group included 23 patients who did not have ROP (no-ROP). Medical records of eligible preterm infants were retrospectively reviewed. Hemogram samples obtained from all patients during the first 24 h of life and samples of their mothers obtained before delivery were evaluated. The hemogram parameters of white blood cell (WBC) count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, and platelet mass index were calculated.

Results No difference was observed between the groups in terms of demographic data. In terms of hematological parameters, maternal WBC counts of ROP patients were significantly higher than those of no-ROP patients and WBC counts of ROP patients were significantly lower than those of no-ROP patients.

Conclusions This study found that high WBC counts in mothers before delivery and/or low WBC counts in preterms during the first postnatal day were higher in developed ROP. These results could lead to the development of prospective studies to assess the real prognostic value of WBC in ROP.

Zusammenfassung

Hintergrund Hämatologische Parameter wurden als Hinweis auf eine erhöhte Entzündungsreaktion bei Morbiditäten sehr unreifer Frühgeborener. Ziel dieser Studie war es festzustellen, ob die hämatologischen Parameter und Verhältnisse von Frühgeborenen ein Risikoindikator für die Entwicklung einer Frühgeborenen-Retinopathie (ROP) sein können.

Material-Methoden Diese retrospektive Kohortenstudie untersuchte Neugeborene, die mit<32 Wochen geboren wurden. 23 Patienten, die mit der Diagnose ROP behandelt wurden, wurden in die Patientengruppe aufgenommen. Die Kontrollgruppe umfasste 23 Patienten ohne ROP. Die medizinischen Aufzeichnungen der in Frage kommenden Frühgeborenen wurden nachträglich überprüft. Hämogrammproben, die von allen Patienten während der ersten 24 Lebensstunden erhalten wurden, und Proben ihrer Mütter, die vor der Entbindung erhalten wurden, wurden ausgewertet. Die Hämogrammparameter der Anzahl weißer Blutkörperchen (WBC), des Verhältnisses von Neutrophilen zu Lymphozyten, des Verhältnisses von Blutplättchen zu Lymphozyten, des Verhältnisses von Lymphozyten zu Monozyten und des Blutplättchenmassenindex wurden berechnet.

Ergebnisse Es gab keinen Unterschied zwischen den Gruppen in Bezug auf demografische Daten. In Bezug auf hämatologische Parameter wurde festgestellt, dass die mütterlichen WBC von Typ-1-ROP-Patienten signifikant höher waren und die WBC-Zahlen von Typ-1-Patienten signifikant niedriger waren als die von Typ-2.

Schlussfolgerungen Die vorliegende Studie ergab, dass hohe WBC-Zahlen bei Müttern vor der Entbindung und/oder niedrige WBC-Zahlen bei Frühgeborenen während des ersten postnatalen Tages bei entwickelten ROP höher waren. Diese Ergebnisse könnten zur Entwicklung prospektiver Studien führen, um den tatsächlichen prognostischen Wert von WBC bei ROP zu bewerten.

Key words

White blood cell count - inflammation - retinopathy of prematurity - premature

Schlüsselwörter

Anzahl weißer Blutkörperchen - Entzündung - Frühgeborenen-Retinopathie

Publication History

Article published online:
18 November 2020

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