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Tierarztl Prax Ausg K Kleintiere Heimtiere 2020; 48(03): 196-202
DOI: 10.1055/a-1162-1338
Kasuistik

Erstbeschreibung des kaninen leproiden Granuloms in Deutschland: 2 Fallberichte

First description of canine leproid granuloma in Germany: 2 case reports
Kathrin Jäger
1   Laboklin Labor für klinische Diagnostik GmbH & Co. KG, Bad Kissingen
,
Agnes Gläsel
2   Klinische Pathophysiologie & Klinische Laboratoriumsdiagnostik, Klinikum Veterinärmedizin, Justus-Liebig-Universität Gießen
,
Doris Hillemann
3   Nationales Referenzzentrum für Mykobakterien, Borstel
,
Nicole Martin
4   Kleintierpraxis am Loderhof, Sulzbach-Rosenberg
,
Julika Theuerkauff
5   Kleintierpraxis Waldenau, Pinneberg
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Zusammenfassung

Bei 2 Hunden wurden im Rahmen der dermatologischen Untersuchung noduläre Hautläsionen im Kopf-/Ohrmuschelbereich nachgewiesen, die mittels histopathologischer, zytologischer und molekularbiologischer Untersuchungen als kanine leproide Granulome charakterisiert werden konnten. Die Erkrankung wird durch nichttuberkulöse, bisher nicht vollständig klassifizierte Mykobakterien verursacht und stellt eine im pazifischen Raum sowie in Nord- und Südamerika dokumentierte Hautläsion dar, die in Deutschland bisher nicht beschrieben wurde. Durch die in beiden Fällen erfolgte Kombination aus chirurgischer und medikamentöser Langzeittherapie (Rifampicin, Clarithromycin, Doxycyclin und lokal Clofazimin) konnten die Granulome entfernt bzw. zur Regression gebracht werden.

Abstract

Using cytology, histopathology, and DNA sequencing the diagnosis of canine leproid granuloma (CLG) was made in 2 dogs. The dogs were presented with nodular skin lesions on the head and pinnae. CLG is caused by nontuberculous mycobacteria that have not yet been finally classified. To date, this disease has been reported in Australia, New Zealand as well as North and South America, however no case reports have been published in Germany until now. In both cases, a combination of surgery and long-term drug administration (rifampicin, clarithromycin, doxycyclin and local application of clofazimin) was chosen and successfully eliminated the granulomas.

Schlüsselwörter

Noduläre Dermatitis - Mykobakterien - DNA-Sequenzierung - Chirurgie

Key words

Nodular dermatitis - mycobacteria - DNA sequencing - surgery


Publication History

Received: 23 October 2019

Accepted: 24 January 2020

Article published online:
18 June 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

  • Literatur

  • 1 Charles J, Martin P, Wigney DI. et al. Cytology and histopathology of canine leproid granuloma syndrome. Aust Vet J 1999; 77: 799-803
    CrossrefPubMedGoogle Scholar
  • 2 Conceição LG, Acha LM, Borges AS. et al. Epidemiology, clinical signs, histopathology and molecular characterization of canine leproid granuloma: a retrospective study of cases from Brazil. Vet Dermatol 2011; 22 (03) 249-256
    CrossrefPubMedGoogle Scholar
  • 3 Dedola C, Zobba R, Pinna Parpaglia ML. et al. First report of canine leprosy in Europe: molecular and clinical traits. Vet Rec 2014; 174 (05) 120
    PubMedGoogle Scholar
  • 4 Foley JE, Borjesson D, Gross TL. et al. Clinical, Microscopic, and Molecular Aspects of Canine Leproid Granuloma in the United States. Vet Pathol 2002; 39: 234-239
    CrossrefPubMedGoogle Scholar
  • 5 Gross TL, Ihrke PJ, Walder EJ. et al. Infectious nodular and diffuse granulomatous and pyogranulomatous diseases of the dermis. In: Gross TL, Ihrke PJ, Walder EJ. et al., eds. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd ed.. Oxford UK: Blackwell Science Ltd; 2005: 272-319
    Google Scholar
  • 6 Hughes MS, James G, Ball N. et al. Identification by 16 S rRNA Gene Analyses of a Potential Novel Mycobacterial Species as an Etiological Agent of Canine Leproid Granuloma Syndrome. J Clin Microbiol 2000; 38 (03) 953-959
    CrossrefPubMedGoogle Scholar
  • 7 Krug S, Himstedt V, Dorn N. et al. Feline Lepra bei einem 5 Monate alten Kater in Deutschland. Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46 (04) 271-275
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Malik R, Love DN, Wigney DI. et al. Mycobacterial nodular granulomas affecting the subcutis and skin of dogs (canine leproidgranuloma syndrome). Aust Vet J 1998; 76 (06) 403-407
    CrossrefPubMedGoogle Scholar
  • 9 Malik R, Martin P, Wigney D. et al. Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs. Aust Vet J 2001; 79 (01) 30-36
    CrossrefPubMedGoogle Scholar
  • 10 Malik R, Smits B, Reppas G. et al. Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 2013; 24 (01) 146-153
    CrossrefPubMedGoogle Scholar
  • 11 Park H, Jang H, Kim C. et al. Detection and identification of mycobacteria by amplification of the internal transcribed spacer regions with genus- and species-specific PCR primers. J Clin Microbiol 2000; 38 (11) 4080-4085
    CrossrefPubMedGoogle Scholar
  • 12 Santoro D, Prisco M, Ciaramella P. Cutaneous sterile granulomas/pyogranulomas, leishmaniasis and mycobacterial infections. J Small Anim Pract 2008; 49 (11) 552-561
    CrossrefPubMedGoogle Scholar
  • 13 Sen Gupta R, Hillemann D, Kubica T. et al. HOPE-fixation enables improved PCR-based detection and differentiation of Mycobacterium tuberculosis complex in paraffin-embedded tissues. Pathol Res Pract 2003; 199 (09) 619-623
    CrossrefPubMedGoogle Scholar
  • 14 Smith RIE. Canine skin tuberculosis. Rhod Vet J 1973; 3: 63-64
    PubMedGoogle Scholar
  • 15 Smits B, Willis R, Malik R. et al. Case clusters of leproid granulomas in foxhounds in New Zealand and Australia. Vet Dermatol 2012; 23 (06) 465-488
    CrossrefPubMedGoogle Scholar