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Fortschr Neurol Psychiatr 2020; 88(09): 591-599
DOI: 10.1055/a-1149-9280
Übersicht

Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom

Structure and efferences of the substantia nigra pars compacta in Parkinson’s disease
Peter Urban
1   Abteilung für Neurologie, Asklepios Klinik Barmbek
,
Bjorn Falkenburger
2   Klinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Dresden
,
Wolfgang H. Jost
3   Parkinson-Klinik Ortenau, Wolfach
,
Gerhard Ransmayr
4   Klinik für Neurologie 2, Kepler Universitätsklinikum, Linz/Austria
,
Peter Riederer
5   Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum Würzburg
,
Christian Winkler
6   Krankenhaus Lindenbrunn, Coppenbrügge
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Zusammenfassung

Es besteht Konsens, dass das neuropathologische Merkmal des idiopathischen Parkinson-Syndroms (IPS) der neuronale Zellverlust der Substantia nigra pars compacta (SNc) in Verbindung mit einer Lewy-Pathologie ist. Die transsynaptische Ausbreitung der Lewy-Pathologie wird als wesentlich in der Parkinson-Pathogenese angesehen. Daher ist die Kenntnis präexistenter neuroanatomischer Verbindungen der SNc wesentlich. Wir beschreiben hier neuere tierexperimentelle Befunde zu den afferenten und efferenten Projektionen der SNc und diskutieren die Evidenz für und gegen die sequentielle transsynaptische Ausbreitung der Lewy-Pathologie in der Pathogenese des IPS.

Abstract

There is consensus that the neuropathological characteristic of Parkinson’s disease (PD) is the neuronal cell loss of the substantia nigra pars compacta (SNc) in connection with a Lewy pathology. The transsynaptic spread of Lewy pathology is considered essential in PD pathogenesis. Therefore, the knowledge of pre-existing neuroanatomical connections of the SNc is essential. We describe recent animal experiments on the afferent and efferent projections of the SNc and discuss the evidence for and against the sequential transsynaptic spread of Lewy pathology in the pathogenesis of PD.

Schlüsselwörter

idiopathisches Parkinson-Syndrom - Lewy-pathology - Substatia nigra - Neuropathologie

Keywords

Parkinson’s disease - Substantia nigra - Neuropathology - Lewy pathology


Publication History

Received: 20 October 2020

Accepted: 24 March 2020

Article published online:
12 May 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

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