Diabetologie und Stoffwechsel 2020; 15(03): 225-234
DOI: 10.1055/a-1145-3224
Übersicht

Stationäre Therapie des Typ-2-Diabetes

Inpatient Treatment of type 2 diabetes
Juris J. Meier
Diabetes-Zentrum Bochum/Hattingen, Katholisches Klinikum Bochum, Klinikum der Ruhr-Universität Bochum
› Author Affiliations

Zusammenfassung

Der überwiegende Teil der Patienten mit Typ-2-Diabetes kann im ambulanten Umfeld (Hausarztpraxen und Diabetes-Schwerpunktpraxen) adäquat und kosteneffektiv behandelt werden. Dennoch erreichen trotz guter ambulanter Versorgungsstrukturen ca. 20–30 % der Patienten keine zufriedenstellende Blutzuckereinstellung. In derartigen Fällen kann eine stationäre Diabetesbehandlung sinnvoll sein. Die Indikationen für eine stationäre Diabetesbehandlung sind in der Nationalen Versorgungsleitlinie Diabetes dargelegt. Besondere Elemente einer stationären Diabetesbehandlung können neben spezifischen Ernährungsinterventionen (z. B. Entlastungstage) spezialisierte Schulungsprogramme, individualisierte Bewegungstherapie ebenso wie eine Anpassung der Insulintherapie bis hin zur intravenösen Insulinbehandlung sein. Eine psychosomatische Mitbetreuung der Patienten erscheint in einer spezialisierten Diabetesbehandlungseinrichtung von essenzieller Bedeutung. Durch die Kombination aus derartigen intensiven Therapiestrategien, einer praktischen Anleitung zur Lebensstilintervention und gruppendynamischen Effekten kann bei vielen Patienten im stationären Rahmen eine deutliche und nachhaltige Verbesserung der Blutzuckereinstellung erzielt werden. Leider ist der Fortbestand derartiger Behandlungseinrichtungen durch die zunehmende Ökonomisierung im Gesundheitssystem und den politisch forcierten Abbau stationärer Versorgungsstrukturen akut gefährdet.

Abstract

The majority of patients with type 2 diabetes can be treated adequately and cost-effectively in outpatient care centers (i. e. by general practitioners or in specialized diabetes outpatient centers). Nevertheless, around 20–30 % of patients do not achieve adequate glycaemic control in those outpatient structures. In such cases inpatient treatment aiming to optimize glycaemic control can be a suitable option. The indications for inpatient treatment of patients with diabetes have been outlined in the national diabetes guideline (“Nationale Versorgungsleitline”). Inpatient care for patients with type 2 diabetes may include specific dietary interventions (e. g. vegetable or oat meal days), specialized training programs, individualized physical therapy as well as the adjustment of insulin therapy, sometimes including transient periods of intravenous insulin therapy. Psychosomatic counselling is a crucial element of inpatient diabetes treatment. Through the combination of intensive pharmacological approaches, practical enforcement of lifestyle intervention and the close interaction amongst affected patients, marked and persistent improvements in glycaemic control can be achieved in a large number of patients undergoing inpatient treatment. Unfortunately, the survival of such inpatients diabetes centers is endangered by the unfavorable reimbursement system and the pressure by politicians and health insurance companies to reduce inpatient treatment capacities.



Publication History

Received: 21 January 2020

Accepted: 23 March 2020

Article published online:
17 April 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 
  • Literatur

  • 1 Meier JJ. Treatment of type 2 diabetes. Internist (Berl) 2016; 57: 153-165
  • 2 Nauck MA, Meier JJ. Diabetes: Incretin mimetics and insulin – closing the gap to normoglycaemia. Nat Rev Endocrinol 2016; 12: 689-690
  • 3 Stark Casagrande S, Fradkin JE, Saydah SH. et al. The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988–2010. Diabetes Care 2013; 36: 2271-2279
  • 4 Tofe S, Arguelles I, Mena E. et al. Real-world GLP-1 RA therapy in type 2 diabetes: A long-term effectiveness observational study. Endocrinol Diabetes Metab 2019; 2: e00051
  • 5 Alatorre C, Fernandez Lando L, Yu M. et al. Treatment patterns in patients with type 2 diabetes mellitus treated with glucagon-like peptide-1 receptor agonists: Higher adherence and persistence with dulaglutide compared with once-weekly exenatide and liraglutide. Diabetes Obes Metab 2017; 19: 953-961
  • 6 Bell KF, Cappell K, Liang M. et al. Comparing Medication Adherence and Persistence Among Patients with Type 2 Diabetes Using Sodium-Glucose Cotransporter 2 Inhibitors or Sulfonylureas. Am Health Drug Benefits 2017; 10: 165-174
  • 7 Rathmann W, Kostev K, Gruenberger JB. et al. Treatment persistence, hypoglycaemia and clinical outcomes in type 2 diabetes patients with dipeptidyl peptidase-4 inhibitors and sulphonylureas: a primary care database analysis. Diabetes Obes Metab 2013; 15: 55-61
  • 8 Holman RR, Farmer AJ, Davies MJ. et al. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 2009; 361: 1736-1747
  • 9 Laugesen E, Ostergaard JA, Leslie RD. et al. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diabet Med 2015; 32: 843-852
  • 10 Anderson RJ, Freedland KE, Clouse RE. et al. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 2001; 24: 1069-1078
  • 11 Lyra ESNM, Lam MP, Soares CN. et al. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Front Psychiatry 2019; 10: 57
  • 12 Smith KJ, Beland M, Clyde M. et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res 2013; 74: 89-99
  • 13 Berard L, Bonnemaire M, Mical M. et al. Insights into optimal basal insulin titration in type 2 diabetes: Results of a quantitative survey. Diabetes Obes Metab 2018; 20: 301-308
  • 14 Munsch S, Herpertz S. Eating disorders associated with obesity and diabetes. Nervenarzt 2011; 82: 1125-1132
  • 15 Kolb H, Martin S. Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes. BMC Med 2017; 15: 131
  • 16 Gupta L, Khandelwal D, Lal PR. et al. Factors Determining the Success of Therapeutic Lifestyle Interventions in Diabetes – Role of Partner and Family Support. Eur Endocrinol 2019; 15: 18-24
  • 17 Petrak F, Meier JJ, Albus C. et al. Motivation und Diabetes – Zeit für einen Paradigmenwechsel?. Diabetologie 2019; 14: 193-23
  • 18 Dong Y, Gao W, Zhang L. et al. Patient characteristics related to metabolic disorders and chronic complications in type 2 diabetes mellitus patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2006 to 2012 in China. Diab Vasc Dis Res 2017; 14: 24-32
  • 19 Balcou-Debussche M, Debussche X. Hospitalization for type 2 diabetes: the effects of the suspension of reality on patientsʼ subsequent management of their condition. Qual Health Res 2009; 19: 1100-1115
  • 20 Ayhan D. Stationäre Diabetestherapie zur glykämischen Kontrolle beim Typ 2-Diabetes – Effizienz nicht-medikamentöser Maßnahmen. Dissertationsschrift. Heinrich Heine Universität Düsseldorf; 2007
  • 21 von Noorden C. Die Haferkur Die Zuckerkrankheit und ihre Behandlung. Verlag von August Hirschwald; 1910: 312-321
  • 22 Lammert A, Kratzsch J, Selhorst J. et al. Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Exp Clin Endocrinol Diabetes 2008; 116: 132-134
  • 23 Delgado G, Kleber ME, Kramer BK. et al. Dietary Intervention with Oatmeal in Patients with uncontrolled Type 2 Diabetes Mellitus – A Crossover Study. Exp Clin Endocrinol Diabetes 2019; 127: 623-629
  • 24 Hou Q, Li Y, Li L. et al. The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Nutrients 2015; 7: 10369-10387
  • 25 Kovatcheva-Datchary P, Nilsson A, Akrami R. et al. Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. Cell Metab 2015; 22: 971-982
  • 26 Shen XL, Zhao T, Zhou Y. et al Effect of Oat beta-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2016; 8 (01) pii: E39 . doi: 10.3390/nu8010039
  • 27 Weickert MO, Mohlig M, Schofl C. et al. Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care 2006; 29: 775-780
  • 28 Lim EL, Hollingsworth KG, Aribisala BS. et al. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011; 54: 2506-2514
  • 29 Steven S, Hollingsworth KG, Al-Mrabeh A. et al. Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders. Diabetes Care 2016; 39: 808-815
  • 30 Lean ME, Leslie WS, Barnes AC. et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet 2018; 391: 541-551
  • 31 Kirk E, Reeds DN, Finck BN. et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 2009; 136: 1552-1560
  • 32 Gustafsson K, Asp NG, Hagander B. et al. Satiety effects of spinach in mixed meals: comparison with other vegetables. Int J Food Sci Nutr 1995; 46: 327-334
  • 33 Rolls BJ, Roe LS, Meengs JS. Salad and satiety: energy density and portion size of a first-course salad affect energy intake at lunch. J Am Diet Assoc 2004; 104: 1570-1576
  • 34 Roe LS, Meengs JS, Rolls BJ. Salad and satiety. The effect of timing of salad consumption on meal energy intake. Appetite 2012; 58: 242-248
  • 35 Guess ND. Dietary Interventions for the Prevention of Type 2 Diabetes in High-Risk Groups: Current State of Evidence and Future Research Needs. Nutrients 2018; 10: 1-13
  • 36 Desalvo DJ, Greenberg LW, Henderson CL. et al. A learner-centered diabetes management curriculum: reducing resident errors on an inpatient diabetes pathway. Diabetes Care 2012; 35: 2188-2193
  • 37 Shai I, Schwarzfuchs D, Henkin Y. et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229-241
  • 38 Estruch R, Ros E, Martinez-Gonzalez MA. Mediterranean diet for primary prevention of cardiovascular disease. N Engl J Med 2013; 369: 676-677
  • 39 Hayes D, Angove MJ, Tucci J. et al. Walnuts (Juglans regia) Chemical Composition and Research in Human Health. Crit Rev Food Sci Nutr 2016; 56: 1231-1241
  • 40 Rock CL, Flatt SW, Barkai HS. et al. Walnut consumption in a weight reduction intervention: effects on body weight, biological measures, blood pressure and satiety. Nutr J 2017; 16: 76
  • 41 Farr OM, Tuccinardi D, Upadhyay J. et al. Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study. Diabetes Obes Metab 2018; 20: 173-177
  • 42 Chen ZP, Stephens TJ, Murthy S. et al. Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes 2003; 52: 2205-2212
  • 43 Mackenzie R, Maxwell N, Castle P. et al. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. J Clin Endocrinol Metab 2012; 97: E546-E555
  • 44 Wen CP, Wai JP, Tsai MK. et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 2011; 378: 1244-1253
  • 45 Villareal DT, Aguirre L, Gurney AB. et al. Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med 2017; 376: 1943-1955
  • 46 Brownrigg JR, Hughes CO, Burleigh D. et al. Microvascular disease and risk of cardiovascular events among individuals with type 2 diabetes: a population-level cohort study. Lancet Diabetes Endocrinol 2016; 4: 588-597
  • 47 Mendes R, Sousa N, Almeida A. et al. Exercise prescription for patients with type 2 diabetes-a synthesis of international recommendations: narrative review. Br J Sports Med 2016; 50: 1379-1381
  • 48 Veronese N, Cooper C, Reginster JY. et al. Type 2 diabetes mellitus and osteoarthritis. Semin Arthritis Rheum 2019; 49: 9-19
  • 49 Ziegler D, Papanas N, Vinik AI. et al. Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol 2014; 126: 3-22
  • 50 Fritsche A, Stefan N, Haring H. et al. Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 2001; 134: 729-736
  • 51 Umpierrez GE, Hellman R, Korytkowski MT. et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2012; 97: 16-38
  • 52 McDonnell ME, Umpierrez GE. Insulin therapy for the management of hyperglycemia in hospitalized patients. Endocrinol Metab Clin North Am 2012; 41: 175-201
  • 53 Buchholz C, Kahle M, Meier JJ. et al. Clinical predictors of the need for further treatment escalation in patients with type 2 diabetes on basal insulin therapy. Exp Clin Endocrinol Diabetes 2019; 127: 663-671
  • 54 Haase M, Kahle M, Janert M. et al. Basal rate tests (24-hour fasts) performed in type-1 diabetic subjects with either absolute fasting or snacks containing negligible carbohydrate amounts result in similar glucose profiles: A randomized controlled prospective trial. Diabetes Obes Metab 2017; 19: 783-790
  • 55 Biesenbach G, Grafinger P, Raml A. Improvement of glycemic control after a 3–5 day insulin infusion in type 2-diabetic patients with insulin resistance can be maintained with glitazone therapy. Wien Klin Wochenschr 2006; 118: 543-548
  • 56 Pouwels MJ, Tack CJ, Hermus AR. et al. Treatment with intravenous insulin followed by continuous subcutaneous insulin infusion improves glycaemic control in severely resistant Type 2 diabetic patients. Diabet Med 2003; 20: 76-79
  • 57 Augustin-Pascalis I, Richard JL, Rodier M. et al. Secondary failure of oral antidiabetics. Value of intravenous insulin infusions. Diabete Metab 1986; 12: 1-5
  • 58 Dandona P, Foster M, Healey F. et al. Low-dose insulin infusions in diabetic patients with high insulin requirements. Lancet 1978; 2: 283-285
  • 59 Laedtke T, Kjems L, Porksen N. et al. Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes. Am J Physiol Endocrinol Metab 2000; 279: E520-E528
  • 60 Rossetti L, Giaccari A, DeFronzo R. Glucose toxicity. Diabetes Care 1990; 13: 610-630
  • 61 Lengeling HF, Landgraf R, Joost HG. Indikationen für eine stationäre Einweisung. Praxis-Leitlinien der Deutschen Diabetes-Gesellschaft. Diabetologie und Stoffwechsel 2002
  • 62 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Therapie des Typ-2-Diabetes – Langfassung (1st edition, Version 3. 2014). 1–251
  • 63 Umpierrez GE, Pasquel FJ. Management of Inpatient Hyperglycemia and Diabetes in Older Adults. Diabetes Care 2017; 40: 509-517
  • 64 Jacobs E, Hoyer A, Brinks R. et al. Healthcare costs of Type 2 diabetes in Germany. Diabet Med 2017; 34: 855-861