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Planta Med 2020; 86(15): 1133-1139
DOI: 10.1055/a-1078-5195
Natural Product Chemistry and Analytical Studies
Original Papers

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root[ # ]

Jandirk Sendker
Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany
,
Matthias Lechtenberg
Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany
,
Andreas Hensel
Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany
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Abstract

The lignan 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil had previously been discovered in a methanolic extract of valerian root (Valeriana officinalis agg.) and characterized as a potent partial agonist at the A1 adenosine receptors. Today, countless scientific sources, webpages, and press articles mention this compound and discuss it as an active constituent for the sedative effect of this herbal drug. As no second report confirmed the occurrence of this lignan in valerian root during the 20 years since its first description in 1998, we intended to re-prove its presence by means of LCMS using other genuine or added lignans as a quantitative benchmark. Whilst those lignans were clearly detectable in methanolic valerian extracts of all six investigated batches of valerian root, no positive proof of 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil was achieved. Our result suggests that this compound does not occur regularly in valerian root in the amounts expected from the single report on the occurrence of this compound.

Key words

Valeriana officinalis - Valeriana edulis - Caprifoliaceae - lignans - olivil - LCMS

# Dedicated to the 85th birthday of Prof. Wolfgang Kubelka, University of Vienna, Austria.


Supporting Information

    Targeted lignans of V. officinalis L. and their expected m/z signals are available as Supporting Information (Table 1S). Expected ions and mass deviations observed for compounds 1 and 3 – 9 in +ESI-QTOF-LCMS spectra are displayed in Table 2S; Figs. 1S – 3S display EIC spectra for the targeted lignans, and Fig. 5S explains the structure search pattern used for pinpointing saccharose derivatives, linked to other moieties by an ether bond in the Reaxys Query system. Macroscopic and microscopic documentation of the pulverized herbal materials is described, and the observed characteristics are displayed in Figs. 6S – 41S.

  • Supporting Information


Publication History

Received: 23 October 2019

Accepted: 05 December 2019

Article published online:
03 January 2020

© 2020. Thieme. All rights reserved.

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