Drug Res (Stuttg) 2020; 70(02/03): 65-70
DOI: 10.1055/a-1078-1087
Review
© Georg Thieme Verlag KG Stuttgart · New York

A Review: Prevention, Treatment and Management of Tuberculosis through Combinational Approaches of Different Indian Systems of Medicine

Priyanka Sharma
1   Departments of Pharmacology and Toxicology, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
,
Ramesh K. Goyal
1   Departments of Pharmacology and Toxicology, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
,
Mukesh Nandave
1   Departments of Pharmacology and Toxicology, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
› Author Affiliations
Further Information

Publication History

received 04 April 2019

accepted 25 November 2019

Publication Date:
13 January 2020 (online)

Abstract

Tuberculosis (TB) is one of the oldest fatal diseases of history. Multidrugresistant tuberculosis (MDRTB) is a major public health issue in the world. In India, the incidence is getting up despite the Indian revised National Tuberculosis Control Programme. India has six recognize medicine systems in this category, namely Ayurveda, Siddha, Unani and Yoga, Naturopathy and Homoeopathy. This review study was undertaken to evaluate the efficacy of different drug treatments based on Indian Systems of Traditional Medicines to the standard MDR-TB regimen. This review mainly focuses on the combinational approaches towards treatment protocols, prevention strategies, and management of tuberculosis in different established systems of medicine in India. Along with allopathic drugs, these AYUSH based drugs work in synergistic manner. Recent research suggests that Homeopathic treatment along with the antibiotics synergise the effect of antibiotics while reaching to its site of action. Additionally in Siddha system, formulation of medicinal herbs showing significant activity against TB bacteria. Furthermore, adopting the management or principles of Unani system would be beneficial in health and disease. Similarly, Unani and Naturopathy through natural healing are equally effective. On the other hand, medicinal plants from the Ayurveda that have been successfully employed to treat TB because of less toxicity and side effect in comparison with existing antibiotics. The findings in this review have provided scientific support for anti-TB activity of different medicinal system of India via numerous underlying mechanisms.

 
  • References

  • 1 News-medical.net [Internet]. History of Tuberculosis. [Last cited on 2010 Oct 15]. Available from http://www.news-medical.net/health/History-of-Tuberculosis.aspx
  • 2 Nobelprize.org [Internet] Sweden: The Nobel Prize in Physiology or Medicine; 1905. Robert Koch. c2010. [Last cited on 2010 Oct 15]. Available from http://nobelprize.org/nobel_prizes/medicine/laureates/1905/koch.html
  • 3 World Health Organization Global Tuberculosis Report. Geneva: WHO; 2009
  • 4 Adhikari PP, Paul SB. History of Indian traditional medicine: a medical inheritance. Asian Journal of Pharmaceutical and Clinical Research 2018; 11: 421-426
  • 5 Sailaja C. Journal of Health & Population in Developing Countries. Vol. 3. WHO publication. A few research outcomes relevant for Public Health from Indian System of Medicine. 2000; 109
  • 6 Debnath PK, Chattopadhyay J, Ghosal D. et al. Immunomodulatory Role of AyurvedicRasayan for Quality of Life. International Nat Conf 2012; Jul-Sep 3: 141-149
  • 7 Davis L, Kuttan G. Effect of Withaniasomnifera on cell mediated immune responses in mice. J Exp Clin Cancer Res 2002; 21: 585-590
  • 8 Vyas P, Chandola HM, Ghanchi F. et al. Clinical evaluation of Rasayana compound as an adjuvant in the management of tuberculosis with anti-Koch’s treatment. Ayu 2012; 33: 38-43
  • 9 Kumar JK, Devi Prasad AG, Chaturvedi V. Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity. Ayu 2014; 35: 98-102
  • 10 Gupta R, Thakur B, Singh P. et al. Chauhan SV. Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates. Indian J Med Res 2010; 131: 809-813
  • 11 Gautam AH, Sharma R, Rana AC. Review on herbal plants useful in Tuberculosis. International Research Journal of Pharmacy 2012; 7: 64-67
  • 12 Chand KS, Manchanda RK, Mittal R. et al. Homeopathic treatment in addition to standard care in multi drug resistant pulmonary tuberculosis: a randomized, double blind, placebo controlled clinical trial. Homeopathy 2014; 103: 97-107
  • 13 Ernst E. A systematic review of systematic reviews of homeopathy. Dr J Clin Pharmacol 2002; 54: 577-582
  • 14 Mubarak H. Siddha marine drug palagarai-areview. Indian journal of geo-marine science 2012; 41: 121-123
  • 15 Elsee GS, Poonkuzhali S, Helen Sathiya H. et al. Anti tuberculosis potential of siddha herbs – a review. european journal of pharmaceutical and medical research 2018; 5: 551-555
  • 16 Parandhama NM, thiruthani M. Literature Review on Siddha Medicines in the treatment of Shayam (Tuberculosis) – A Review. International Journal of Current Research in Medical Sciences 2018; 4: 35-39
  • 17 Suvetha C, Vanitha A, Pushparani RM. et al. Anti tuberculosis activity of a Siddha herbal formulation for treating tuberculosis in children. International Journal of Advanced Research in Biological Sciences 2016; 3: 173-177
  • 18 Kitab RJ. Al-Havi Central Council of Research ion Unani Medicine. New Delhi 1991; 334-335: 404-408
  • 19 Syed K, Roy CR, Muchatar RU. editors Traditional Medicine in Asia. New Delhi: WHO- Regional Office for South East Asia; 2002: 31-46
  • 20 Jamil S, Azhar J, ahmed S. pulmonary tuberculosis and its management in classical unani literature. Indian journal of traditional knowledge. 2005; 2143-2149
  • 21 Razi Z. Kitabul-Mansoori New Delhi: (Urdu Translation CCRUM). 1991; P. 171 354: 404-408
  • 22 Smith MJ, Logan AC. Naturopathy. Medical Clinics of North America 2002; 86: 173-184
  • 23 Kirkwood G, Rampes H, Tuffrey V. et al. Yoga for anxiety: a systematic review of the research evidence. Br J Sports Med 2005; 39: 884-891
  • 24 Prasad HK, Singhal A, Mishra A. et al. Bovine tuberculosis in India: potential basis for zoonosis. Tuberculosis (Edinb) 2005; 85: 421-428
  • 25 Shrivastava K, Chauhan DS, Gupta P. et al. Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India–possible relevance in human health. Indian J Med Res 2008; 128: 26-31
  • 26 Sandhu GK. Tuberculosis: Current Situation, Challenges and Overview of its Control Programs in India. journal of global infectious diseases 2011; 3: 143-150