Download PDF
Drug Res (Stuttg) 2020; 70(01): 6-11
DOI: 10.1055/a-0991-7585
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

Elham Ahmadian
1   Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2   Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3   Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
,
Solmaz Maleki Dizaj
1   Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
,
Aziz Eftekhari
4   Maragheh University of Medical Sciences, Maragheh, Iran
,
Elaheh Dalir
5   Research Center for Pharmaceutical Nanotechnology, Biomedicine Institue, Tabriz University of Medical Sciences, Tabriz, Iran
,
Parviz Vahedi
4   Maragheh University of Medical Sciences, Maragheh, Iran
,
Amir Hasanzadeh
4   Maragheh University of Medical Sciences, Maragheh, Iran
,
Mohammad Samiei
6   Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
› Author Affiliations
Further Information

Publication History

received 12 May 2019

accepted 05 August 2019

Publication Date:
25 September 2019 (online)

Also available at
    Permissions and Reprints

Abstract

Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.

Key words

regenerative medicine - drug delivery - biopharmaceuticals
 

  • References

  • 1 Segura T, Anderson BC, Chung PH. et al. Crosslinked hyaluronic acid hydrogels: A strategy to functionalize and pattern. Biomaterials 2005; 26: 359-371
    CrossrefPubMedGoogle Scholar
  • 2 Tripodo G, Trapani A, Torre ML. et al. Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges. Eur J Pharm Biopharm 2015; 97: 400-416
    CrossrefPubMedGoogle Scholar
  • 3 Anseth KS, JAJMB Burdick. New directions in photopolymerizable biomaterials. Dent Mater 2002; 27: 130-136
    PubMedGoogle Scholar
  • 4 Caló E, VVJEPJ Khutoryanskiy. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J 2015; 65: 252-267
    CrossrefPubMedGoogle Scholar
  • 5 Donnelly RF, Singh TRR, Garland MJ. et al. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv Funct Mater 2012; 22: 4879-4890
    CrossrefPubMedGoogle Scholar
  • 6 Cook JP, Goodall GW, Khutoryanskaya OV. et al. Microwave–assisted hydrogel synthesis: A new method for crosslinking polymers in aqueous solutions. Macromol Rapid Commun 2012; 33: 332-336
    CrossrefPubMedGoogle Scholar
  • 7 Korogiannaki M, Guidi G, Jones L. et al. Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials. J Biomater Appl 2015; 30: 361-376
    CrossrefPubMedGoogle Scholar
  • 8 Burdick JA, Prestwich GD. Hyaluronic acid hydrogels for biomedical applications. Advanced Materials 2011; 23: H41-H56
    CrossrefPubMedGoogle Scholar
  • 9 Mehrali M, Thakur A, Pennisi CP. et al. Nanoreinforced hydrogels for tissue engineering: Biomaterials that are compatible with load-bearing and electroactive tissues. Adv Mater 2017; 29: 1603612
    CrossrefPubMedGoogle Scholar
  • 10 Nicodemus GD, SJJTEPBR Bryant. Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng Part B Rev 2008; 14: 149-165
    PubMedGoogle Scholar
  • 11 Burdick JA, Vunjak-Novakovic GJTEPA. Engineered microenvironments for controlled stem cell differentiation. Tissue Eng Part A 2008; 15: 205-219
    PubMedGoogle Scholar
  • 12 Murua A, Portero A, Orive G. et al. Cell microencapsulation technology: Towards clinical application. J Control Release 2008; 132: 76-83
    CrossrefPubMedGoogle Scholar
  • 13 Lee BR, Hwang JW, Choi YY. et al. In situ formation and collagen-alginate composite encapsulation of pancreatic islet spheroids. Biomaterials 2012; 33: 837-845
    CrossrefPubMedGoogle Scholar
  • 14 Toh WS, Lee EH, Guo X-M. et al. Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. Biomaterials 2010; 31: 6968-6980
    CrossrefPubMedGoogle Scholar
  • 15 Prestwich GDJJocr. Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. J Control Release 2011; 155: 193-199
    CrossrefPubMedGoogle Scholar
  • 16 Ratliff BB, Ghaly T, Brudnicki P. et al. Endothelial progenitors encapsulated in bioartificial niches are insulated from systemic cytotoxicity and are angiogenesis competent. Am J Physiol Renal Physiol 2010; 299: F178-F186
    CrossrefPubMedGoogle Scholar
  • 17 Zhong J, Chan A, Morad L. et al. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair 2010; 24: 636-644
    CrossrefPubMedGoogle Scholar
  • 18 Liu Y, Shu XZ, GDJTe Prestwich. Tumor engineering: orthotopic cancer models in mice using cell-loaded, injectable, cross-linked hyaluronan-derived hydrogels. Tissue Eng 2007; 13: 1091-1101
    CrossrefPubMedGoogle Scholar
  • 19 Shu XZ, Ahmad S, Liu Y. et al. Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res B 2006; 79: 902-912
    PubMedGoogle Scholar
  • 20 Zhang Q, Yamaza T, Kelly AP. et al. Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis. PLoS One 2009; 4: e7798
    CrossrefPubMedGoogle Scholar
  • 21 Marrero B, Messina JL, RJIVC Heller. et al. Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma. In Vitro Cell Dev Biol Anim 2009; 45: 523-534
    CrossrefPubMedGoogle Scholar
  • 22 Zhang H, Xu X, Gajewiak J. et al. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res 2009; 69: 5441-5449
    CrossrefPubMedGoogle Scholar
  • 23 Cai S, Liu Y, Shu XZ. et al. Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials 2005; 26: 6054-6067
    CrossrefPubMedGoogle Scholar
  • 24 Peattie RA, Pike DB, Yu B. et al. Effect of gelatin on heparin regulation of cytokine release from hyaluronan-based hydrogels. Curr Drug Deliv 2008; 15: 389-397
    CrossrefPubMedGoogle Scholar
  • 25 Hosack LW, Firpo MA, Scott JA. et al. Microvascular maturity elicited in tissue treated with cytokine-loaded hyaluronan-based hydrogels. Biomaterials 2008; 29: 2336-2347
    CrossrefPubMedGoogle Scholar
  • 26 Hanjaya-Putra D, Yee J, Ceci D. et al. Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells. J Cell Mol Med 2010; 14: 2436-2447
    CrossrefPubMedGoogle Scholar
  • 27 Zhao J, Zhang N, Prestwich GD. et al. Recruitment of endogenous stem cells for tissue repair. Macromol Biosci 2008; 8: 836-842
    CrossrefPubMedGoogle Scholar
  • 28 Mansbridge JN, Liu K, Pinney RE. et al. Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers. Diabetes Obes Metab 1999; 1: 265-279
    CrossrefPubMedGoogle Scholar
  • 29 Jha AK, Yang W, Kirn-Safran CB. et al. Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release. Biomaterials 2009; 30: 6964-6975
    CrossrefPubMedGoogle Scholar
  • 30 Khademhosseini A, Eng G, Yeh J. et al. Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. J Biomed Mater Res B 2006; 79: 522-532
    PubMedGoogle Scholar
  • 31 Burdick Jason A, Glenn D.. Prestwich. Hyaluronic acid hydrogels for biomedical applications. Adv Mater 2011; 23: H41-H56
    CrossrefPubMedGoogle Scholar
  • 32 Oelker Abigail M, Jason A. Berlin, Michel Wathier, and Mark W. Grinstaff Synthesis and characterization of dendron cross-linked PEG hydrogels as corneal adhesives. Biomacromolecules 2011; 12: 1658-1665
    CrossrefPubMedGoogle Scholar
  • 33 Yeh J, Ling Y, Karp JM. et al. Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials 2006; 27: 5391-5398
    CrossrefPubMedGoogle Scholar
  • 34 Figallo E, Cannizzaro C, Gerecht S. et al. Micro-bioreactor array for controlling cellular microenvironments. Lab Chip 2007; 7: 710-719
    CrossrefPubMedGoogle Scholar
  • 35 Elisseeff JJEoobt. Injectable cartilage tissue engineering. Expert Opin Biol 2004; 4: 1849-1859
    PubMedGoogle Scholar
  • 36 Liu M, Zeng X, Ma C. et al. Injectable hydrogels for cartilage and bone tissue engineering. Bone research 2017; 5: 17014
    CrossrefPubMedGoogle Scholar
  • 37 Chung C, Erickson IE, Mauck RL. et al. Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels. Tissue Eng Part A 2008; 14: 1121-1131
    CrossrefPubMedGoogle Scholar
  • 38 Erickson IE, Huang AH, Sengupta S. et al. Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. Osteoarthritis and Cartilage 2009; 17: 1639-1648
    CrossrefPubMedGoogle Scholar
  • 39 Chung C, Mesa J, Randolph MA. et al. Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks. J Biomed Mater Res A 2006; 77: 518-525
    PubMedGoogle Scholar
  • 40 Nettles DL, Vail TP, Morgan MT. et al. Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Ann Biomed Eng 2004; 32: 391-397
    CrossrefPubMedGoogle Scholar
  • 41 Domingues RM, Silva M, Gershovich P. et al. Development of injectable hyaluronic acid/cellulose nanocrystals bionanocomposite hydrogels for tissue engineering applications. Bioconjug Chem 2015; 26: 1571-1581
    CrossrefPubMedGoogle Scholar
  • 42 Vahedi P, Soleimanirad J, Roshangar L. et al. Advantages of sheep infrapatellar fat pad adipose tissue derived stem cells in tissue engineering. Adv Pharm Bull 2016; 6: 105
    PubMedGoogle Scholar
  • 43 Vahedi P, Jarolmasjed S, Shafaei H. et al. In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold. Tissue Cell 2019; 57: 49-56
    CrossrefPubMedGoogle Scholar
  • 44 Vahedi P, Roshangar L, Jarolmasjed S. et al. Effect of low-intensity pulsed ultrasound on regenerative potential of transplanted ASCs-PCL construct in articular cartilage defects in sheep. Indian J Anim Sci 2016; 86: 1111-1114
    PubMedGoogle Scholar
  • 45 Gourdie RG, Dimmeler S, Kohl P. Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nat Rev Drug Discov 2016; 15: 620
    CrossrefPubMedGoogle Scholar