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Tierarztl Prax Ausg K Kleintiere Heimtiere 2019; 47(01): 55-59
DOI: 10.1055/a-0828-6657
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Remission of diabetes mellitus after ovariohysterectomy in a guinea pig with ovarian cysts

Remission eines Diabetes mellitus nach Ovariohysterektomie bei einem Meerschweinchen mit Ovarialzysten
Theresa Kreilmeier-Berger
1   Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine, University of Veterinary Medicine, Vienna, Austria
,
Abigail Guija-De-Arespacochaga
2   Department of Pathobiology, Clinical Pathology Platform, University of Veterinary Medicine, Vienna, Austria
,
Andrea Bilek
1   Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine, University of Veterinary Medicine, Vienna, Austria
,
Frank Künzel
1   Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine, University of Veterinary Medicine, Vienna, Austria
› Author Affiliations
Further Information

Publication History

08/31/2018

01/03/2019

Publication Date:
26 February 2019 (online)

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Abstract

A 3-year-old intact female guinea pig was presented with a history of polydipsia, polyphagia, and hyperactivity combined with non-pruritic hair loss. The physical examination revealed bilateral alopecia mainly including the flanks and the ventral abdomen. Bilateral rounded masses just caudal to the kidneys were detected on abdominal palpation. Abdominal ultrasound examination confirmed bilateral ovarian cysts and an enlarged uterus with cystic lesions. Blood biochemistry revealed highly increased glucose and fructosamine concentrations. The final diagnoses were diabetes mellitus, bilateral ovarian cysts, and pathologic changes of the uterus. The guinea pig underwent ovariohysterectomy. After surgery, diabetes mellitus and all of the existing clinical signs were fully resolved. A causal relationship between hormonally active ovarian cysts and diabetes mellitus that commonly present independently from each other in the guinea pig can be strongly assumed in the present case. In suspicious cases of gestagen-induced diabetes mellitus ovariohysterectomy could be considered a potential treatment option in guinea pigs.

Zusammenfassung

Ein 3-jähriges weibliches Meerschweinchen wurde mit der Anamnese von Polydipsie, Polyphagie, Verhaltensveränderungen sowie Haarverlust ohne Juckreiz vorgestellt. Die klinische Untersuchung ergab eine bilaterale Alopezie an den Flanken und dem ventralen Abdomen. Bei der abdominalen Palpation wurden bilaterale rundliche Massen kaudal der Nieren getastet. Die sonographische Untersuchung des Abdomens bestätigte das Vorliegen von bilateralen Ovarialzysten und einen vergrößerten, zystisch veränderten Uterus. Die biochemische Blutuntersuchung zeigte stark erhöhte Glukose- und Fruktosaminkonzentrationen. Aufgrund der Befunde wurden die Diagnosen Diabetes mellitus, bilaterale Ovarialzysten sowie pathologische Uterusveränderungen gestellt und das Meerschweinchen ovariohysterektomiert. Danach kam es zu einer Remission des Diabetes mellitus sowie der ursprünglich vorliegenden Symptome. Im Fall dieses Meerschweinchens ist ein kausaler Zusammenhang zwischen den hormonell aktiven Ovarialzysten und dem Diabetes mellitus sehr wahrscheinlich. Bei Verdacht eines gestageninduzierten Diabetes mellitus beim Meerschweinchen kann die Ovariohysterektomie als Behandlungsoption erwogen werden.

Key words

Insulin resistance - gestagen-induced - fructosamine - bilateral symmetrical alopecia - polydipsia

Schlüsselwörter

Insulinresistenz - gestageninduziert - Fruktosamin - bilaterale symmetrische Alopezie - Polydipsie
 

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