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TumorDiagnostik & Therapie 2018; 39(09): 586-589
DOI: 10.1055/a-0664-2540
Schwerpunkt Hepatozelluläres Karzinom
© Georg Thieme Verlag KG Stuttgart · New York

Lokal-ablative Verfahren in der Therapie des HCC

Philipp Kasten
,
Steffen Zender
,
Andrej Potthoff
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Publication Date:
26 October 2018 (online)

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Perkutane lokal-ablative Therapieverfahren spielen im Behandlungsalgorithmus des hepatozellulären Karzinoms eine wichtige Rolle. Infolge der Komplexität der klinischen Gesamtsituation – mit häufig zugrunde liegender Leberzirrhose und folglich limitierten Möglichkeiten einer operativen Resektion – stellen die loko-regionären Verfahren eine wirksame und potenziell kurative Therapieoption dar.
 

  • Literatur

  • 1 Crocetti L, Lencioni R. Thermal ablation of hepatocellular carcinoma. Cancer Imaging 2008; 8: 19-26
    CrossrefPubMedGoogle Scholar
  • 2 Makarova-Rusher OV, Altekruse SF, McNeel TS. et al. Population attributable fractions of risk factors for hepatocellular carcinoma in the United States. Cancer 2016; 122: 1757-1765
    CrossrefPubMedGoogle Scholar
  • 3 EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol 2018; 69: 182-236
    CrossrefPubMedGoogle Scholar
  • 4 Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): Diagnostik und Therapie des hepatozellulären Karzinoms, Langversion 1.0, AWMF Registrierungsnummer: 032-053O.
    PubMedGoogle Scholar
  • 5 Lencioni RA, Allgaier HP, Cioni D. et al. Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology 2003; 228: 235-240
    CrossrefPubMedGoogle Scholar
  • 6 Germani G, Pleguezuelo M, Gurusamy K. et al. Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar a meta-analysis. J Hepatol 2010; 52: 380-388
    CrossrefPubMedGoogle Scholar
  • 7 Nault JC, Sutter O, Nahon P. et al. Percutaneous treatment of hepatocellular carcinoma: State of the art and innovations. J Hepatol 2018; 68: 783-797
    CrossrefPubMedGoogle Scholar
  • 8 Weis S, Franke A, Mössner J. et al. Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma. Cochrane Database Syst Rev 2013; 12: CD003046
    PubMedGoogle Scholar
  • 9 Chinnaratha MA, Chuang MY, Fraser RJ. et al. Percutaneous thermal ablation for primary hepatocellular carcinoma: A systematic review and meta-analysis. J Gastroenterol Hepatol 2016; 31: 294-300
    CrossrefPubMedGoogle Scholar
  • 10 Violi NV, Duran R, Guiu B. et al. Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial. Lancet Gastroenterol Hepatol 2018; 3: 317-325
    CrossrefPubMedGoogle Scholar
  • 11 Livraghi T, Lazzaroni S, Meloni F. et al. Risk of tumour seeding after percutaneous radiofrequency ablation for hepatocellular carcinoma. Br J Surg 2005; 92: 856-858
    CrossrefPubMedGoogle Scholar
  • 12 Livraghi T, Solbiati L, Meloni MF. et al. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 2003; 226: 441-451
    CrossrefPubMedGoogle Scholar
  • 13 Curley SA, Marra P, Beaty K. Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Ann Surg 2004; 239: 450-458
    CrossrefPubMedGoogle Scholar
  • 14 Widmann G, Schullian P, Haidu M. et al. Stereotactic radiofrequency ablation (SRFA) of liver lesions: technique effectiveness, safety, and interoperator performance. Cardiovasc Intervent Radiol 2012; 35: 570-580
    CrossrefPubMedGoogle Scholar