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Horm Metab Res 2018; 50(08): 627-639
DOI: 10.1055/a-0643-4739
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study

Gretha J. Boersma
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
,
Emil Johansson
2   Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
,
Maria J. Pereira
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
,
Kerstin Heurling
2   Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
7   Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden
,
Stanko Skrtic
3   AstraZeneca, R & D, Gothenburg, Sweden
4   Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
,
Joey Lau
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
5   Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
,
Petros Katsogiannos
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
,
Grigorios Panagiotou
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
,
Mark Lubberink
2   Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
,
Joel Kullberg
2   Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
6   Antaros Medical, Mölndal, Sweden
,
Håkan Ahlström
2   Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
6   Antaros Medical, Mölndal, Sweden
,
Jan W. Eriksson
1   Department of Medical Science, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
› Author Affiliations
Further Information

Publication History

received 28 February 2018

accepted 07 June 2018

Publication Date:
12 July 2018 (online)

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Correction to:

Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR StudyHorm Metab Res 2018; 50(08): e10-e10
DOI: 10.1055/a-0831-3620

Abstract

We assessed glucose uptake in different tissues in type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact in the development of whole-body insulin resistance and T2D. Thirteen T2D, 12 prediabetes, and 10 control subjects, matched for age and BMI, underwent OGTT and abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated whole-body 18F-FDG PET and MRI were performed during a hyperinsulinemic euglycemic clamp to asses glucose uptake rate (MRglu) in several tissues. MRglu in skeletal muscle, SAT, visceral adipose tissue (VAT), and liver was significantly reduced in T2D subjects and correlated positively with M-values (r=0.884, r=0.574, r=0.707 and r=0.403, respectively). Brain MRglu was significantly higher in T2D and prediabetes subjects and had a significant inverse correlation with M-values (r=–0.616). Myocardial MRglu did not differ between groups and did not correlate with the M-values. A multivariate model including skeletal muscle, brain and VAT MRglu best predicted the M-values (adjusted r2=0.85). In addition, SAT MRglu correlated with SAT glucose uptake ex vivo (r=0.491). In different stages of the development of T2D, glucose uptake during hyperinsulinemia is elevated in the brain in parallel with an impairment in peripheral organs. Impaired glucose uptake in skeletal muscle and VAT together with elevated glucose uptake in brain were independently associated with whole-body insulin resistance, and these tissue-specific alterations may contribute to T2D development.

Key words

diabetes mellitus type 2 - glucose intolerance - insulin resistance - PET-MRI imaging

Supplementary Material

 

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