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Fortschr Neurol Psychiatr 2019; 87(04): 217-224
DOI: 10.1055/a-0624-9368
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Prävention und Behandlung von Antipsychotika-induzierten tardiven Dyskinesien

Prevention and Treatment of Antipsychotic-induced Tardive Dyskinesia
Sebastian Erbe
Martin Gropius Krankenhaus GmbH, Klinik für Psychiatrie, Psychotherapie und Psychosomatik
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Further Information

Publication History

eingereicht 23 January 2018

akzeptiert 28 April 2018

Publication Date:
11 July 2018 (online)

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Zusammenfassung

Tardive Dyskinesien (TD) sind immer noch häufige Langzeitfolgen einer Behandlung mit Antipsychotika. Sie sind meist irreversibel, mit einer geringeren Lebensqualität und kognitiven Defiziten assoziiert und ein Risikofaktor für erhöhte Sterblichkeit. Auch führen sie häufig zu einer weiteren Stigmatisierung der betroffenen Patienten. In der Behandlung von schweren psychiatrischen Krankheitsbildern sind Antipsychotika aber weiterhin nicht entbehrlich. Deshalb ist das Wissen insbesondere über die Prävention und die Risikofaktoren aber auch über die Behandlung von TD bei der Verordnung von Antipsychotika sehr wichtig. Die Behandlung von TD besteht in der Optimierung der antipsychotischen Pharmakotherapie. Des Weiteren können gezielte medikamentöse Behandlungen erfolgen. Hierbei kommt den sogenannten VMAT-2-Inhibitoren eine besondere Rolle zu. Die neuen VMAT-2-Inhibitoren sind in Deutschland noch nicht zugelassen. Weitere Medikamente zur Behandlung der TD sind unter anderem Clonazepam und Gingko biloba. Dieser Übersichtsartikel fasst die gegenwärtige Evidenz für die Behandlung von TD zusammen und versucht klinische Empfehlungen zur Prävention und Behandlung von TD zu formulieren.

ABSTRACT

Tardive dyskinesias (TDs) are still common long-term sequelae of antipsychotic treatment. They are generally irreversible and associated with cognitive deficits, a decrease in quality of life and increased mortality. Furthermore, they potentially contribute to further stigmatization of the affected patients. However due to limited treatment options, antipsychotic drugs are still one of the cornerstones in treatment of most severe mental illnesses. Therefore, knowledge about risk factors and prevention of TDs is crucial. If TDs occur, the immediate optimization of the antipsychotic drug regimen is required. Targeted medical treatments such as VMAT - 2 inhibitors can be considered. The novel VMAT-2 inhibitors are not yet approved in Germany. Other drugs that are currently used to treat TDs include clonazepam and gingko biloba. This review summarizes the current evidence of treatment options of TDs and seeks to formulate clinical recommendations for the prevention and management of TDs.

Schlüsselwörter

tardive Dyskinesie - Antipsychotika - Prävention - Behandlung - VMAT-2-Inhibitor

Key words

tardive dyskinesia - antipsychotics - prevention - treatment - VMAT-2-inhibitor
 

  • Literatur

  • 1 Schott H, Tölle R. Geschichte der Psychiatrie: Krankheitslehren, Irrwege, Behandlungsformen. 1.. Aufl. München: C.H.Beck; 2005
    Google Scholar
  • 2 Flügel F, Bente D. Das akinetisch-abulische Syndrom. Dtsch Med Wochenschr 1956; 51: 2071-2074
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Kulenkampff C, Tarnow G. Ein eigentümliches Syndrom im oralen Bereich bei Megaphenapplikation. Nervenarzt 1956; 27 (04) 178-180
    PubMed
  • 4 Hall RA, Jackson RB, Swain JM. Neurotoxic reactions resulting from chlorpromazine administration. JAMA 1956; 161 (03) 214-218
    CrossrefPubMedGoogle Scholar
  • 5 Schoenecker M. Beitrag zu der Mitteilung von Kulenkampff und Tarnow: Ein eigentümliches Syndrom im oralen Bereich bei Megaphenapplikation. Nervenarzt 1957; 28: 35
    PubMedGoogle Scholar
  • 6 Sigwald J, Bouttier D, Raymondeaud C. et al. Quatre cas de dyskinesie facio-bucco-Iinguo-masticatrice a I’evolution prolongee secondaire a un traitemant par les neuroleptiques. Rev Neurol 1959; 100: 751-755
    PubMedGoogle Scholar
  • 7 Pirker W. Therapeutische Entwicklungen bei tardiven Dyskinesien (01.12.2016). Im Internet: http://ch.universimed.com/fachthemen/7796 ; Stand: 16.11.2017
    PubMedGoogle Scholar
  • 8 Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov 2013 ; doi: 10.7916 / D88P5Z71
    PubMed
  • 9 Orti-Pareja M, Jimenez-Jimenez FJ, Vasquez A. et al. Drug-induced tardive syndromes. Parkinsonism Relat Disord 1999; 5: 59-65
    CrossrefPubMedGoogle Scholar
  • 10 Fleischhacker WW, Hofer A, Jagsch C. et al. Antipsychotikainduzierte tardive Syndrome. Neuropsychiatr 2016; 30: 123-130
    CrossrefPubMedGoogle Scholar
  • 11 Schooler NR, Kane JM. Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 1982; 39 (04) 486-487
    PubMedGoogle Scholar
  • 12 Buhmann C, Rizos A, Emmans D. et al. Interkulturelle Adaption der AIMS in deutscher Sprache. Eine Skala für abnorme unwillkürliche Bewegungen. Nervenarzt 2016; 87: 411-417
    CrossrefPubMedGoogle Scholar
  • 13 Browne S, Roe M, Lane A. et al. Quality of life in schizophrenia: relationship to sociodemographic factors, symptomatology and tardive dyskinesia. Acta Psychiatr Scand 1996; 94 (02) 118-124
    CrossrefPubMedGoogle Scholar
  • 14 Ballesteros J, González-Pinto A, Bulbena A. Tardive dyskinesia associated with higher mortality in psychiatric patients: results of a meta-analysis of seven independent studies. J Clin Psychopharmacol 2000; 20 (02) 188-194
    CrossrefPubMedGoogle Scholar
  • 15 Caroff SN, Davis VG, Miller DD. et al. Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia. J Clin Psychiatry 2011; 72 (03) 295-303
    CrossrefPubMedGoogle Scholar
  • 16 Chong SA, Tay JA, Subramaniam M. et al. Mortality rates among patients with schizophrenia and tardive dyskinesia. J Clin Psychopharmacol 2009; 29 (01) 5-8
    CrossrefPubMedGoogle Scholar
  • 17 Angermeyer MC, Matschinger H, Schomerus G. Attitudes towards psychiatric treatment and people with mental illness: changes over two decades. Br J Psychiatry 2013; 203 (02) 146-151
    CrossrefPubMedGoogle Scholar
  • 18 Correll C, Leucht S, Kane J. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: A systematic review of 1-year studies. Am J Psychiatry 2004; 161 (03) 414-425
    CrossrefPubMedGoogle Scholar
  • 19 Margolese H, Chouinard G, Kolivakis T. et al. Tardive dyskinesia in the era of typical and atypical antipsychotics. Part 1: Pathophysiology and mechanisms of induction. Can J Psychiatry 2005; 50 (09) 541-547
    PubMedGoogle Scholar
  • 20 Chang FC, Fung VS. Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders. Pharmgenomics Pers Med 2014; 7: 317-328
    PubMedGoogle Scholar
  • 21 Pakpoor J, Agius M. A review of the adverse side effects associated with antipsychotics as related to their efficacy. Psychiatr Danub 2014; 26 Suppl 1 : 273-284
    PubMedGoogle Scholar
  • 22 Caroff SN, Hurford I, Lybrand J. et al. Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial. Neurol Clin 2011; 29 (01) 127-148
    CrossrefPubMedGoogle Scholar
  • 23 Citrome L, Dufresne R, Dyrud JM. Tardive dyskinesia: minimizing risk and improving outcomes in schizophrenia and other disorders. Am J Manag Care 2007; 13: 1-12
    PubMedGoogle Scholar
  • 24 Fenton WS. Prevalence of spontaneous dyskinesia in schizophrenia, J Clin Psychiatry 2000; 61: 10-14
    PubMed
  • 25 Koning JPF, Tenback DE, van Os J. et al. Dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis. Schizophr Bull 2010; 36 (04) 723-731
    CrossrefPubMedGoogle Scholar
  • 26 Caroff SN, Ungvari GS, Cunningham Owens DG. Historical perspectives on tardive dyskinesia. J Neurol Sci 2018 doi.org / 10.1016 / j.jns.2018.02.015
    PubMed
  • 27 Merrill RM, Lyon JL, Matiaco PM. Tardive and spontaneous dyskinesia incidence in the general population. BMC Psychiatry 2013; 13 (01) 152-160
    CrossrefPubMedGoogle Scholar
  • 28 Casey DE. Tardive dyskinesia and atypical antipsychotic drugs, Schizophr Res 1999; 35 (Suppl): S61-66
    PubMed
  • 29 Bhidayasiri R, Tarsy D. Movement disorders: a video atlas (Current Clinical Neurology). 1.. Aufl. New York: Humana Press; Springer Science Business Media; 2012
    Google Scholar
  • 30 Ceballos-Baumann A, Conrad B. Bewegungsstörungen. 2.. Aufl. Stuttgart: Thieme-Verlag; 2005
    Google Scholar
  • 31 Cloud LJ, Zutshi D, Factor SA. Tardive dyskinesia: therapeutic options for an increasingly common disorder. Neurotherapeutics 2014; 11: 166-176
    CrossrefPubMedGoogle Scholar
  • 32 Carbon M, Hsieh CH, Kane JM. et al. Tardive dyskinesia prevalence in the period of second-generation antipsychotic use: a meta-analysis. J Clin Psychiatry 2017; 78 (03) e264-e278
    CrossrefPubMedGoogle Scholar
  • 33 Correll CU, Schenk EM. Tardive dyskinesia and new antipsychotics. Curr Opin Psychiatry 2008; 21 (02) 151-156
    CrossrefPubMedGoogle Scholar
  • 34 Kenney C, Hunter C, Davidson A. et al. Metoclopramide, an increasingly recognized cause of tardive dyskinesia. J Clin Pharmacol 2008; 48: 379-384
    CrossrefPubMedGoogle Scholar
  • 35 Jankelowitz SK. Treatment of neurolept-induced tardive dyskinesia. Neuropsychiatr Dis Treat 2013; 9: 1371-1380
    PubMedGoogle Scholar
  • 36 Wonodi I, Adami HM, Cassady SL. et al. Ethnicity and the course of tardive dyskinesia in outpatients presenting to the motor disorders clinic at the Maryland psychiatric research center. J Clin Psychopharmacol 2004; 24 (06) 592-598
    CrossrefPubMedGoogle Scholar
  • 37 Gertz HJ, Stoppe G, Müller-Oerlinghausen B. et al. Antipsychotika zur Behandlung neuropsychiatrischer Störungen bei Demenz. Nervenarzt 2013; 84: 370-373
    CrossrefPubMedGoogle Scholar
  • 38 Bohlken J, Booker A, Kostev K. Hohe Prävalenz der Verwendung von Antipsychotika bei Demenzpatienten in deutschen neurologischen und psychiatrischen Praxen. Fortschr Neurol Psychiatr 2017; 85: 345-351
    Article in Thieme ConnectPubMedGoogle Scholar
  • 39 Sheehan R, Hassiotis A, Walters K. et al. Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study. BMJ 2015; 351: h4326
    PubMedGoogle Scholar
  • 40 Tarsy D, Lungu C, Baldessarini RJ. Epidemiology of tardive dyskinesia before and during the era of modern antipsychotic drugs. Handb Clin Neurol 2011; 100: 601-616
    PubMedGoogle Scholar
  • 41 Correll CU, Kane JM, Citrome LL. Epidemiology, prevention, and assessment of tardive dyskinesia and advances in treatment. J Clin Psychiatry 2017; 78 (08) 1136-1147
    CrossrefPubMedGoogle Scholar
  • 42 Kane JM. Schizophrenia. N Engl J Med 1996; 334 (01) 34-41
    CrossrefPubMedGoogle Scholar
  • 43 Glazer WM, Morgenstern H, Schooler N. et al. Predictors of improvement in tardive dyskinesia following discontinuation of neuroleptic medication. Br J Psychiatry 1990; 157: 585-592
    CrossrefPubMedGoogle Scholar
  • 44 Zutshi D, Cloud L, Factor S. Tardive syndromes are rarely reversible after discontinuing dopamine receptor blocking agents: experience from a university-based movement disorder clinic. Tremor Other Hyperkinet Mov 2014 doi: 10.7916 / D8MS3R8C
    PubMedGoogle Scholar
  • 45 Bhidayasiri R, Fahn S, Weiner WJ. et al. Evidence-based guideline: treatment of tardive syndromes: report of the guideline development subcommittee of the American Academy of Neurology.. Neurology 2013; 81: 463-469
    CrossrefPubMedGoogle Scholar
  • 46 Gross RA, Johnston KC. Levels of evidence: taking Neurology to the next level. Neurology 2009; 72 (01) 8-10
    CrossrefPubMedGoogle Scholar
  • 47 Thaker GK, Nguyen JA, Strauss ME. et al. Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. Am J Psychiatry 1990; 147: 445-451
    CrossrefPubMedGoogle Scholar
  • 48 Fraugera E, Pauly V, Pradel V. et al. Evidence of clonazepam abuse liability: results of the tools developed by the French Centers for Evaluation and Information on Pharmacodependence (CEIP) network. Fundam Clin Pharmacol 2011; 25 (05) 633-641
    CrossrefPubMedGoogle Scholar
  • 49 Zhang WF, Tan YL, Zhang XY. et al. Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo controlled trial. J Clin Psychiatry 2011; 72: 615-621
    CrossrefPubMedGoogle Scholar
  • 50 Fachinformation Amantadin-ratiopharm® 100 mg Filmtabletten. Stand: März 2010 . ratiopharm GmbH, Ulm. Zulassungsnummer 37050.00.00
    PubMed
  • 51 Angus S, Sugars J, Boltezar R. et al. A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia. J Clin Psychopharmacol 1997; 17: 88-91
    CrossrefPubMedGoogle Scholar
  • 52 Pappa S, Tsouli S, Apostolou G. et al. Effects of amantadine on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. Clin Neuropharmacol 2010; 33: 271-275
    CrossrefPubMedGoogle Scholar
  • 53 Caroff SN, Aggarwal S, Yonan C. Treatment of tardive dyskinesia with tetrabenazine or valbenazine: a systematic review. J Comp Eff Res 2017 doi: 10.2217 / cer-2017-0065
    PubMedGoogle Scholar
  • 54 Fachinformation Nitoman® 25 mg Tabletten. Stand: April 2016 . Hormosan Pharma GmbH, Frankfurt am Main. Zulassungsnummer 58924.00.00
    PubMed
  • 55 Yero T, Rey JA. Tetrabenazine (Xenazine), an FDA-approved treatment option for Huntington’s disease – related chorea. P&T 2008; 33 (012) 690-694
    PubMedGoogle Scholar
  • 56 Hauser RA, Factor SA, Marder SR. et al. KINECT 3: a Phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia. Am J Psychiatry 2017; 174: 476-484
    CrossrefPubMedGoogle Scholar
  • 57 O’Brien CF, Jimenez R, Hauser RA. et al. NBI-98854, a selective monoamine transport inhibitor for the treatment of tardive dyskinesia: a randomized, double-blind, placebo-controlled study. Mov Disord 2015; 30 (12) 1681-1687
    CrossrefPubMedGoogle Scholar
  • 58 Factor SA, Remington G, Cormella CL. et al. The effects of valbenazine in participants with tardive dyskinesia: results of the 1-Year KINECT 3 extension study. J Clin Psychiatry 2017 ; doi: 10.4088 / JCP.17 m11777
    PubMedGoogle Scholar
  • 59 Anderson KE, Stamler D, Davis MD. et al. Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Psychiatry 2017; 4 (08) 595-604
    CrossrefPubMedGoogle Scholar
  • 60 Fernandez HH, Factor SA, Hauser RA. et al. Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD study. Neurology 2017; 88 (21) 2003-2010
    CrossrefPubMedGoogle Scholar
  • 61 Citrome L. Deutetrabenazine for tardive dyskinesia: A systematic review of the efficacy and safety profile for this newly approved novel medication—What is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract 2017 ; DOI: 10.1111 / ijcp.13030
    PubMed
  • 62 Bhidayasiri R, Jitkritsadakul O, Friedman JH. et al. Updating the recommendations for treatment of tardive syndromes: A systematic review of new evidence and practical treatment algorithm. J Neurol Sci 2018 ; doi: 10.1016 / j.jns.2018.02.010
    PubMedGoogle Scholar
  • 63 Pouclet-Courtemanche H, Rouaud T, Thobois S. et al. Long-term efficacy and tolerability of bilateral pallidal stimulation to treat tardive dyskinesia. Neurology 2016; 86: 651-659 d
    PubMed
  • 64 Morigaki R, Mure H, Kaji R. et al. Therapeutic perspective on tardive syndrome with special reference to deep brain stimulation. Front Psychiatry 2016; 7:: 207 . doi: 10.3389 / fpsyt.2016.00207. eCollection. 2016;
    PubMedGoogle Scholar
  • 65 Salem H, Pigott T, Zhang XY. et al. Antipsychotic-induced tardive dyskinesia: from biological basis to clinical management. Expert Rev Neurother 2017; 17 (09) 883-894
    CrossrefPubMedGoogle Scholar
  • 66 Chaplin R, Kent A. Informing patients about tardive dyskinesia: controlled trial of patient education. Br J Psychiatry 1998; 172: 78-81
    CrossrefPubMedGoogle Scholar
  • 67 Kleinman I, Schachter D, Koritar E. Informed consent and tardive dyskinesia. Am J Psychiatry 1989; 146: 902-904
    CrossrefPubMedGoogle Scholar
  • 68 Kleinman I, Schachter D, Jeffries J. et al. Informed consent and tardive dyskinesia: long-term follow-up. J Nerv Ment Dis 1996; 184: 517-522
    CrossrefPubMedGoogle Scholar
  • 69 Cornett EM, Novitch M, Kaye AD. et al Medication-Induced Tardive Dyskinesia: A Review and Update. Ochsner J 2017; 17 (02) 162-174
    PubMedGoogle Scholar