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Homeopathy 2009; 98(02): 83-87
DOI: 10.1016/j.homp.2009.02.002
Original Paper
Copyright © The Faculty of Homeopathy 2009

Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity – experimental studies

R.M. Kuzeff
1   Consultant in Homeopathy, National Institute of Integrative Medicine, Melbourne, Australia
,
M. Topashka-Ancheva
2   Institute of Zoology, Bulgarian Academy of Sciences, Sofia, Bulgaria
,
R. Metcheva
2   Institute of Zoology, Bulgarian Academy of Sciences, Sofia, Bulgaria
› Author Affiliations
Subject Editor:
Further Information

Publication History

Received14 September 2008
revised01 February 2009

accepted11 February 2009

Publication Date:
15 December 2017 (online)

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Background: Previous studies have investigated toxicity inhibition of optically active compounds by potentized preparations of their enantiomers. It was hypothesised that inhibition of toxicity may be stereospecific. This paper presents 2 studies investigating stereoisomer potencies in terms of their ability to counteract toxicity of the (−) stereoisomer. The stereoisomers used were (−)-trans-(1S,2S)-U-50488 HCl and (+)-trans-(1R,2R)-U-50488 HCl.

Materials & methods: Designs were prospective, blind, randomised, intention-to-treat and compared the efficacy of 2 indistinguishable treatments. The outcome was the difference in survival. Potency ‘chords’ consisting of 4th, 12th and 30th approximately centesimal dilutions were prepared, representing concentrations of 1.08 × 10−10 M. One study compared inhibition of (−)-U-50488 toxicity injected ip at the estimated LD50 into male ICR mice, treated with a potency chord of the same stereoisomer, with control (‘isopathic’ study). The other study compared inhibition of toxicity by potency chords made from the stereoisomers (+)-U-50488 and (−)-U-50488 (‘enantiomer’ study), Treatments were administered orally on 11 occasions: twice before and nine times after ip injections.

Results: The isopathic study did not yield a significant result. In the enantiomer study, comparison of isopathy with enantiomer potency treatment showed a highly significant difference odds ratio 1.97 (95% CI: 1.23–3.14).

Conclusion: We conclude that enantiomeric potencies are superior to identically produced isopathic potencies, in inhibiting toxicity of (−)-U-50488 HCl. Homeopathic inhibition of toxicity may be stereospecific.

Keywords

homeopathy - isopathy - stereoisomer - optical isomer - patent - mice - enantiomer
 

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