DOI: 10.1055/s-00000084

Synthesis

References

During the optimization process, we observed that excess benzaldehyde (>1.25 equiv) inhibits the second step of the reaction(cyclization), which causes contamination of product with aldol-type adducts and decreases the reaction yield. We assume that this effect is based on interaction of the O-anion of with the carbonyl group of excess aldehyde and formation of a hemiacetal-type adduct. This type of equilibrium operates, for example, in the reaction of the anion of 2-chloroethanol with aldehydes: Barbasiewicz M, Mąkosza M,
Org. Lett.. 2006; 8 3745 

Download Bibliographical Data

Access:
Access:
Access: