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It has been reported that the separation of enantiomers of 2-(alkylthio)quinazolin-4-ones bearing an ortho-fluorophenyl group is difficult because of the low rotational barrier around the C–N bond; see: Jira T. Schopplich C. Bunke A. Leuthold L. Junghänel J. Theiss R. Kottke K. Besch A. Beyrich T.
Pharmazie 1996;
51: 379

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