Acid-induced cyclization to form the halichondrin C17–C20 tetrahydrofuran ring was first noted by Yu and co-workers at Eisai. Acidic acetonide cleavage of erythrose derivative A resulted in clean in situ cyclization to furnish the C14–C21 subunit (Scheme 7). See: Yu MJ, Tremblay L, Davis HA, Palme MH, Sexton KA, Zheng W.
Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000.
American Chemical Society.
Washington DC: 2000 ; Abstract ORGN-739.
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