DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 61 · January 2023 DOI: 10.1055/s-013-56316


39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Bochum, 27.–28.01.2023

Kongresspräsident:
Prof. Dr. Ali Canbay
Abstracts (HTML) Abstracts (PDF) List of Authors
P5.01
Kellerer, Mareike; Tiegs, Gisa; Neumann, Katrin; Javed, Sana; Berkhout, Laura: Regulation of immune response and hepatic fibrosis by the cytotoxic effector molecules granzyme B and TRAIL in sclerosing cholangitis in mice
P5.02
Kinast, Volker; Andreica, Ioana; Ahrenstorf, Gerrit; Gömer, André; Elsner, Carina; Schlienkamp, Sarah; Schrader, JilAlexandra; Broering, Ruth; Vondran, Florian; Todt, Daniel; Behrendt, Patrick; Dittmer, Ulf; Witte, Torsten; Baraliakos, Xenofon; Steinmann, Eike: Janus kinase inhibitors modulate hepatitis E virus infection
P5.03
Buechler, Christa: Antiviral cure and liver cirrhosis change the serum cholesteryl ester profile in patients with chronic hepatitis C
P5.04
Wedemeyer, Heiner; Aleman, Soo; Brunetto, Maurizia; Blank, Antje; Andreone, Pietro; Bogomolov, Pavel; Chulanov, Vladimir; Mamonova, Nina; Geyvandova, Natalia; Morozov, Viacheslav; Sagalova, Olga; Stepanova, Tatyana; Manuilov, Dmitry; Suri, Vithika; An, Qi; Flaherty, John; Osinusi, Anu; zur Wiesch, JulianSchulze; Cornberg, Markus; Zeuzem, Stefan; Lampertico, Pietro: Efficacy and Safety of Bulevirtide Monotherapy Given at 2 mg or 10 mg Dose Level Once Daily for Treatment of Chronic Hepatitis Delta: Week 48 Primary Endpoint Results from a Phase 3 Randomized, Multicenter, Parallel Design Study
P5.05
Khanal, Rajendra; Heinen, Natalie; Bogomolova, Alexandra; Meister, ToniLuise; Todt, Daniel; Jockenhövel, Freya; Vondran, Florian; Brown, RichardJ.P.; Steinmann, Eike; Zimmer, Gert; Ott, Michael; Pfaender, Stephanie; Sharma, AmarDeep: Relevance of microRNAs in SARS-CoV-2 infection of primary human hepatocytes
P5.06
Niehaus, Christian; Wedemeyer, Heiner; Falk, ChristineS.; Björkström, NiklasK.; Kraft, Anke; Cornberg, Markus; Strunz, Benedikt: CD103 identifies an ascites-resident NK cell subset with reduced effector capacity that originates in the intestine
P5.07
Laue, Fenja; Nörenberg, Pia; Kohn, Martin; Dinkelborg, Katja; Ssebyatika, George; Hüffner, Lucas; Zeiß, Frithjof; Wedemeyer, Heiner; Pietschmann, Thomas; Krey, Thomas; Behrendt, Patrick: mRNA based expression of Hepatitis E specific neutralizing antibodies in liver cells as therapeutic option
P5.08
Dinkelborg, Katja; Kahlhöfer, Julia; Dörge, Petra; Port, Kerstin; Yurdaydin, Cihan; Wedemeyer, Heiner; Deterding, Katja: Qualitiy of life-scores improve after 96 weeks of PEG-IFNa-2a treatment of hepatitis D: an analysis of the HIDIT-II trial
P5.09
Buti, Maria; Wedemeyer, Heiner; Aleman, Soo; Chulanov, Vladimir; Morozov, Viacheslav; Sagalova, Olga; Stepanova, Tatyana; Gish, Robert; Lloyd, Andrew; Kaushik, Ankita; Suri, Vithika; Manuilov, Dmitry; Osinusi, Anu; Flaherty, John; Lampertico, Pietro: Treatment with Bulevirtide Improves Patient-reported Outcomes in Patients with Chronic Hepatitis Delta: An Exploratory Analysis of a Phase 3 Trial at 48 Weeks
P5.10
Gömer, André; Klöhn, Mara; Jagst, Michelle; Horvatits, Thomas; zur Wiesch, JulianSchulze; Pischke, Sven; Müller, Tobias; Wedemeyer, Heiner; Cornberg, Markus; Behrendt, Patrick; Steinmann, Eike; Todt, Daniel: Intra-host diversity of hepatitis E virus polymerase during sofosbuvir treatment
P5.11
Fehlau, Lukas; Klause, Tanja; Dinkelborg, Katja; Ssebyatika, George; Hüffner, Lucas; Wedemeyer, Heiner; Maasoumy, Benjamin; Pietschmann, Thomas; Krey, Thomas; Behrendt, Patrick: The Interplay of antigen and antibody in HEV infection
P5.12
Schefczyk, Stefan; Luo, Xufeng; Liang, Aojie; Hasenberg, Mike; Walkenfort, Bernd; Merz, Simon; Bornemann, Lea; Trippler, Martin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, HartmutH.; Broering, Ruth: Characterization of viral replication in different Hepatitis B virus-transgenic mice and its impact on antiviral signalling in vivo
P5.13
Klöhn, Mara; Brüggemann, Yannick; Windisch, Marc; Todt, Daniel; Steinmann, Eike: Automated high-throughput image-based screen discovers members of the Akt serine/threonine kinase family as targets for treatment of HEV virus infection in vitro
P5.14
Aratari, Lea; Pavel, Vlad; Gülow, Karsten; Müller-Schilling, Martina; Schmid, Stephan: Liver and COVID-19 – Identification of early prognostic markers
P5.15
Wißing, MichaelHermann; Knegendorf, Leonard; Allweiss, Lena; Siddharta, Anindya; Gisa, Anett; Bremer, Birgit; Lütgehetmann, Marc; Behrendt, Patrick; Wedemeyer, Heiner; Steinmann, Eike; Todt, Daniel: HEV genomic insertions identified in chronic patients enhance viral fitness
P5.16
Killer, Alexander; Gliga, Smaranda; Pullmann, David; Jensen, Björn; Walker, Andreas; Lübke, Nadine; Timm, Jörg; Lüdde, Tom; Bock, Hans: HBV reactivation after start of bulevirtide mono-treatment for a HBV/HDV coinfected patient: a case report
P5.17
Mangia, Alessandra; Fagiuoli, Stefano; Di Marco, Vito; Shafran, Stephen; Khalili, Mandana; Milligan, Scott; Papatheodoridis, George; Ouzan, Denis; Rosati, Silvia; Ramji, Alnoor; Teti, Elisabetta; Garcia-Retortillo, Montserrat; Hernández, FranciscoAndrésPérez; Wong, Alexander; Fraser, Chris; Rodriguez-Tajes, Sergio; Mutiloa, ElenaJimenèz; Amado, LuisEnriqueMorano; O’Loan, Joss; Campanale, Francesca; Macedo, Guilherme; Milella, Michele; Brixko, Christian; Buti, Maria; Veloz, MariaGuerra; Ranieri, Roberto; Borgia, Sergio; Bascia, Annalisa; Baganz, Lisa; Rodriguez, ConradoManuelFernandez; Conway, Brian; de Ledinghen, Victor; Fenech, Mary; Ryan, Pablo; Maida, Ivana; Martins, Alexandra; Scherbakovsky, Stacey; Ntalla, Ioanna; Hernandez, Candido; Vanstraelen, Kim; Turnes, Juan: Changing HCV patient profiles: insights from a large multinational real-world sofosbuvir/velpatasvir (SOF/VEL) dataset
P5.18
Wolski, Annika; Knoop, Eva; Mader, Maria; Kling, Lena; Wagner, Antje; Horvatits, Thomas; Stiller, Jenny; Krohn, Barbara; Groschup, MartinH.; zur Wiesch, JulianSchulze; Eiden, Martin; Pischke, Sven: Anti-HEV seroprevalence varies largely in dogs, cats, and horses in Germany
P5.19
Tacke, Frank; Turnes, Juan; Hintz, Andreas; Fagiuoli, Stefano; Sicras-Mainar, Antoni; Umland, Tim; Esposti, LucaDegli; Verdugo, RamónMorillo; Herola, AntonioGarcia; Guendogdu, Mehtap; Baganz, Lisa; Mendez, Marinela; Nieto, GemaAlvarez; Vanstraelen, Kim; Hernandez, Candido; Mangia, Alessandra: Polypharmacyand prevalence of multi drug-drug interactions in hepatitis C patients treated with pangenotypic direct acting antivirals: an analysis from three European countries
P5.20
Knodel, MarkusM.; Nägel, Arne; Herrmann, Eva; Wittum, Gabriel: Intracellular “in silico microscopes” – fully 3D spatial Hepatitis C virus replication model simulations
P5.21
Allweiss, Lena; Volmari, Annika; Ladiges, Yvonne; Eggers, Corinna; Suri, Vithika; Wallin, Jeffrey; Flaherty, John; Manuilov, Dmitry; Lütgehetmann, Marc; Wedemeyer, Heiner; Urban, Stephan; Bockmann, Jan-Hendrik; Dandri, Maura: Strong decline of intrahepatic HDV markers and signs of liver inflammation after 48 weeks of treatment with Bulevirtide in chronic hepatitis D patients: Combined intrahepatic results from the clinical trials MYR203 and MYR301
P5.22
Volmari, Annika; Quitt, Oliver; Volz, Tassilo; Allweiss, Lena; Protzer, Ulrike; Dandri, Maura: HBs-directed T cell engager antibodies foster efficient recruitment of T cells and lead to strong reduction of HBV infection in livers of humanized mice
P5.23
Steppich, Katja; Souleiman, Roni; Bruni, Elena; Lara, XimenaLeon; Prinz, Immo; Kraft, Anke; Cornberg, Markus: The role of CXCR6+γδ T cells in chronic hepatitis B virus (HBV) infection
P5.24
Urbanek-Quaing, Melanie; Oltmanns, Carlos; Mischke, Jasmin; Wedemeyer, Heiner; Kraft, Anke; Cornberg, Markus: Targeting epigenetic imprints to modulate HBV-specific T cell responses
P5.25
Aliabadi, Elmira; Hrabal, Isabella; Dinkelborg, Katja; Wedemeyer, Heiner; Eiden, Martin; Groschup, MartinH.; Behrendt, Patrick: Vaccine to Inhibit Autochthonous Transmission of Hepatitis (VaccinATE)
P5.26
Mischke, Jasmin; Klein, Sebastian; Wedemeyer, Heiner; Cornberg, Markus; Kraft, Anke: Single cell analysis of HCV and heterologous virus-specific CD8+T cell responses in patients with chronic hepatitis C before and after HCV elimination
P5.27
Schwinge, Dorothee; Bahn, Jonas; Kunzmann, Lilly; Casar, Christian; Krause, Jenny; Steinmann, Silja; Sebode, Marcial; Lohse, AnsgarW.; Huber, Samuel; Franke, Andre; Gagliani, Nicola; Schramm, Christoph; Poch, Tobias: The risk-variant rs56258221 at the BACH2-locus associates with skewed polarization of naive CD4+T cells towards pro-inflammatory phenotypes in primary sclerosing cholangitis
P5.28
Hinte, Florian; Schmidt, Daniel; Schneider, Carola; Lütgehetmann, Marc; Pischke, Sven; Dandri-Petersen, Maura: Characterisation of HEV particles in serum, urine, ejaculate and stool using a linear gradient ultracentrifugation technique
P5.29
Wuehrl, Michael; Ringelhan, Marc; Ehmer, Ursula; Schneider, Jochen; Kager, Juliane; Lahmer, Tobias; Schneider, Anna; Weichert, Wilko; Mogler, Carolin: When the pathologist is not too late (for once) – rare infectious causes of acute hepatic dysfunction with distinct histopathological features.
P5.30
Langer, Mona-May; Guckenbiehl, Sabrina; Bauschen, Alina; Denk, Gerald; Lange, ChristianM.: Inflammatory profiles are different between patients with EASL-CLIF- versus APASL-acute-on-chronic liver failure
P5.31
Henze, Lara; Stein, Stephanie; Meyer, Jasper; Poch, Tobias; Krause, Jenny; Casar, Christian; Fuß, Johannes; Renné, Thomas; Schwinge, Dorothee; Schramm, Christoph: The effect of testosterone on human T cells in health and autoimmune liver disease
P5.32
Kolbe, Jonathan; Volz, Tassilo; Volmari, Annika; Allweiss, Lena; Giersch, Katja; Lütgehetmann, Marc; Dandri, Maura: In vivo labeling of nascent viral HBV and HDV RNA for investigating viral replication and clearance kinetics
P5.33
Lübbering, David; Preti, Max; Schlott, Lena; Schultheiß, Christoph; Weidemann, Sören; Lohse, AnsgarW.; Binder, Mascha; Carambia, Antonella; Herkel, Johannes: Intrahepatically activated and antigen-selected B cells are bystanders, not drivers of autoantigen-driven hepatitis in mice
P5.34
Fischer, Janett; Kraps, Kai-Uwe; Müller, Tobias; Heyne, Renate; Berg, Thomas; van Bömmel, Florian: Association of a TLR7 variant with spontaneous clearance of hepatitis B virus infection in Caucasians
P5.35
Fischer, Janett; Long, Shuang; Koukoulioti, Eleni; Müller, Tobias; Heyne, Renate; Eslam, Mohammed; George, Jacob; Finkelmeier, Fabian; Waidmann, Oliver; Berg, Thomas; van Bömmel, Florian: Association of variants of interleukin 10 and 12A with the progression of hepatitis B virus infection in Caucasians
P5.36
Schmidt, Daniel; Hinte, Florian; Allweiss, Lena; Volz, Tassilo; Lütgehetmann, Marc; Dandri-Petersen, Maura: Comparative analysis and distribution of distinct HBV particles and antigens in serum of patients and human liver chimeric mice according to density
P5.37
Zeuzem, Antonia; Oltmanns, Carlos; Mischke, Jasmin; Kumar, Saumya; Drick, Nora; Fuge, Jan; Pink, Isabell; Debarry, Jennifer; Illig, Thomas; Wedemeyer, Heiner; Li, Yang; Kraft, Anke; Cornberg, Markus: Distinct profiles and kinetics of soluble inflammatory markers in patients with acute and chronic HCV-infections and SARS-CoV-2-infections: Implications for the long-term consequences of viral infections?
P5.38
Pohl, Junika; Georgieva, Alexandra; Weber, Julius; Kager, Juliane; Deschler, Sebastian; Laschinger, Melanie; Hartmann, Daniel; Böttcher, JanPhilipp; Hüser, Norbert; Schmid, RolandMichael; Knolle, PercyAlexander; Böttcher, Katrin: Mucosal-associated invariant T cell are rendered dysfunctional within the tumour microenvironment in HCC in a cell-contact dependent manner
P5.38
Pfefferkorn, Maria; Hahn, Carolin; Deichsel, Danilo; Pavlovic, Vedran; Wat, Cynthia; Berg, Thomas; van Bömmel, Florian: Heterogeneity of hepatitis B virus (HBV) basal core promotor (BCP) variants during treatment with peginterferon alfa-2a is associated with low HBV replication
P5.39
Ekmen, Onder: A Case of Fulminant Hepatitis B Reactivation After Hepatitis C Treatment in Hepatitis B+C Co-infection