DOI: 10.1055/s-00000058

Planta Medica

Issue 02 · Volume 88 · February 2022 DOI: 10.1055/s-012-52733 Focus Issue Pyrrolizidine Alkaloids

Editorial

97
Editorial

Focus Issue Pyrrolizidine Alkaloids

Reviews

98
Schrenk, Dieter; Fahrer, Jörg; Allemang, Ashley; Fu, Peter; Lin, Ge; Mahony, Catherine; Mulder, Patrick P.J.; Peijnenburg, Ad; Pfuhler, Stefan; Rietjens, Ivonne M.C.M.; Sachse, Benjamin; Steinhoff, Barbara; These, Anja; Troutman, John; Wiesner, Jacqueline: Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–A Workshop Report
Supporting Information
118
Wiesner, Jacqueline: Regulatory Perspectives of Pyrrolizidine Alkaloid Contamination in Herbal Medicinal Products
125
Steinhoff, Barbara: Pyrrolizidine Alkaloid Contamination in Medicinal Plants: Regulatory Requirements and Their Impact on Production and Quality Control of Herbal Medicinal Products
130
Widjaja, Frances; Alhejji, Yasser; Rietjens, Ivonne M. C. M.: The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides
Supporting Information

Original Papers

144
Plaza, Alberto; Toner, Frank; Harris, James; Ottersbach, Peter; Roper, Clive; Mahony, Catherine: Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin

Biological and Pharmacological Activity

Original Papers

152
Schäfer, Anima M.; Gilgen, Pierrine M.; Spirgi, Clara; Potterat, Olivier; Meyer zu Schwabedissen, Henriette E.: Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2
Supporting Information
163
Pradubyat, Nalinee; Giannoudis, Athina; Elmetwali, Taha; Mahalapbutr, Panupong; Palmieri, Carlo; Mitrpant, Chalermchai; Ketchart, Wannarasmi: 1′-Acetoxychavicol Acetate from Alpinia galanga Represses Proliferation and Invasion, and Induces Apoptosis via HER2-signaling in Endocrine-Resistant Breast Cancer Cells
Supporting Information