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DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 58 · January 2020 DOI: 10.1055/s-009-45326

Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)
36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Mainz, 14.–15.02.2020

Kongresspräsident: Prof. Dr. Peter Galle

Abstracts (HTML) List of Authors

Poster Visit Session IV Tumors: Saturday, February 15, 2020, 8:30 am – 09:15 am, Lecture Hall P1

4.4

Lu, M; Hartmann, D; Braren, R; Gupta, A; Wang, B; Wang, Y; Mogler, C; Cheng, Z; Wirth, T; Friess, H; Kleeff, J; Hüser, N; Sunami, Y: Hepatic activation of FOXO3 regulates mTORC2-Akt and enhances oxidative damage-associated hepatocellular carcinogenesis

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4.5

Seitz, T; Freese, K; Dietrich, P; Thasler, WE; Bosserhoff, A; Hellerbrand, C: Expression and Function of Fibroblast Growth Factor 9 in hepatocellular carcinoma

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4.6

Tóth, M; Schmitt, J; Weiler, SME; Schirmacher, P; Rössler, S; Goeppert, B; Breuhahn, K: Dysregulation of Hippo/Yap signaling induces chromosome instability in intrahepatic cholangiocarcinoma

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4.7

Truckenmueller, F; Goeppert, B; Pusch, S; Heinze, I; Kirkpatrick, J; Schirmacher, P; Ori, A; Roessler, S: Quantitative LC-MS-based shot gun proteomics identifies deregulated proteins in gallbladder carcinoma

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4.8

Schmiel, M; Wang, L; Wang, J; Yu, X; Dalvi, P; Buettner, R; Odenthal, M: Influence on hepatocellular carcinoma energy metabolism by pharmacological inhibition of the epigenetic modifier LSD1

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4.9

Mahn, FL; Castven, D; Pereira, SP; Hartmann, M; Fahrer, J; Andersen, JB; Matter, MS; Gaiser, T; Rössler, S; Galle, PR; Marquardt, JU: KRAS-mutated intrahepatic cholangiocarcinoma shows preferential sensitivity towards PARP-1-based interventions

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4.10

Weiler, S; Lutz, T; Bissinger, M; Knaub, M; Sticht, C; Gretz, N; Schirmacher, P; Breuhahn, K: The TAZ target gene ITGAV regulates invasion and positively feedbacks on YAP and TAZ in liver cancer cells

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4.11

Thiess, L; Mwewa, N; Schirmacher, P; Breuhahn, K: The desmosomal cadherin desmoglein-2 regulates the Hippo pathway effector yes-associated protein (YAP) in liver cancer

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4.12

Rose, F; El-Ekiaby, N; Sticht, C; Schirmacher, P; Gretz, N; Abdelaziz, AI; Breuhahn, K: Strategies to identify oncogene-dependent long non-coding RNAs (lncRNAs) in liver cancer

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4.13

Freese, K; Seitz, T; Dietrich, P; Lee, SML; Thasler, WE; Bosserhoff, A; Hellerbrand, C: Histone deacetylases (HDAC) expressions in HCC and functional effects of HDAC inhibitors in liver cancer cells

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4.14

Castven, D; Czauderna, C; Becker, D; Pereira, S; Breuhahn, K; Schmitt, J; Wörns, M; Thorgeirsson, S; Grimminger, P; Lang, H; Galle, PR; Marquardt, JU: Cancer stem cells as significant drivers of sorafenib resistance in hepatocellular carcinoma

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4.15

Schöler, U; Kraczyk, J; Priebe, M; Casar, C; Fründt, T; Krause, J; Werner, T; Jung, C; Ittrich, H; Lohse, AW; Felden, J von; Wege, H; Schulze, K: Improvement in median OS in patients with advanced HCC and strict eligibility criteria receiving Sorafenib

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4.16

Ridder, D; Berndt, K; Witzel, HR; Weinmann, A; Marquardt, JU; Schindeldecker, M; Heinrich, S; Roth, W; Straub, B: HILPDA is upregulated, predicts prognosis and promotes cancer progression in hepatocellular carcinoma

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4.17

Vorhauer, L; Seitz, T; Hellerbrand, C: Expression and function of Epithelial Splicing Regulatory Protein 1 in hepatocellular carcinoma

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4.18

Sommer, J; Hellerbrand, C: Expression and Function of Four-and-a-Half LIM-domain protein 2 (FHL2) in Hepatocellular Carcinoma

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4.19

Heinrichs, D; Wirtz, TH; Saal, A; Bergmann, I; Fischer, P; Brandt, EF; Bernhagen, J; Trautwein, C; Berres, ML: Macrophage Migration Inhibitory Factor promotes HCC progression in vivo via the receptor CD74

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4.20

Alex, S; Dabiri, Y; Dropmann, A; Cheng, X; Ming, T; Wölfl, S; Dooley, S: Smad3 linker (S213 and S204) phosphorylation as indicators for the prediction of cholangiocarcinoma outcome

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4.21

Aprupe, L; Schmitt, J; Liu, K; Schirmacher, P; Kummer, U; Breuhahn, K: Mathematical modeling of the YAP/TAZ shuttling as a response to cell density, actin dynamics, and liver damaging drugs

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4.22

Schäfer, J; Janssen, H; Bicker, A; Galle, P; Strand, D; Marquardt, J; Strand, S: Loss of Sirtuin6 induces expression of the cancer-related transmembrane protein TMEM45A in HepG2 cells

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4.23

Piche, J; Otto, T; Mohs, A; Woitok, MM; Trautwein, C: The role of ferroptosis in chronic liver disease

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4.24

Mohs, A; Otto, T; Schneider, KM; Peltzer, MT; Boekschoten, M; Trautwein, C: The NRF2/KEAP1 pathway in hepatocytes controls fibro- and carcinogenesis in chronic liver disease

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4.25

Yu, X; Eischeid, H; Schmiel, M; Büttner, R; Odenthal, M: Overexpression of tumor suppressor miR-198 in hepatoma cells leads to its spontaneous and active export via vesicles

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4.26

Sieker, J; Schuller, S; Drucker, E; Riemenschneider, P; Dauch, D; Ori, A; Holzer, K; Dombrowski, F; Singer, S: HELLS is an important p53 repression target in liver cancer

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4.27

Hu, Q; Dai, Z; Balakrishnan, A; Sharma, AD; Ott, M; Yuan, Q: Clinically applicable liver repopulation: the role of thymidine kinase and ganciclovir (GCV)

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4.28

Ridder, D; Urbansky, L; Witzel, HR; Weinmann, A; Marquardt, JU; Schindeldecker, M; Heinrich, S; Koehler, B; Roth, W; Straub, B: TGFβ-activated kinase 1 (TAK1) is activated and predicts prognosis in hepatocellular carcinoma

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4.29

Straub, B; Gerber, TS; Zimbelmann, R; Cahyadi, O; Stenzel, P; Ridder, D; Jäkel, J; Försch, S; Martin, SZ; Schirmacher, P; Roth, W; Franke, WW: Cis-E:N-Cadherin-Heterodimere als Charakteristikum von Tumoren des hepatopankreatobiliären Systems

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4.30

Hahn, F; Müller, L; Tanyildizi, Y; Pinto dos Santos, D; Düber, C; Galle, PR; Weinmann, A; Kloeckner, R; Mähringer-Kunz, A: Distant metastases in patients with intrahepatic cholangiocarcinoma: Does location matter?

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4.31

Pereira, S; Rodrigues, L; Castven, D; Mahn, FL; Dooley, S; Meindl-Beinker, NM; Lang, H; Grimminger, P; Galle, P; Marquardt, J: Dual role of Transforming Growth Factor Beta1&2 during Tumor Promotion and Metastasis in Primary Liver Cancer

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4.32

Michalski, M; Wiesner, O; Müller-Schilling, M; Gülow, K: Dimethyl fumarate (DMF) inhibits migration and proliferation of hepatocellular carcinoma (HCC)

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4.33

Melzer, T; Sommer, J; Hellerbrand, C: Analysis of the expression and function of KIAA1199 in hepatocellular carcinoma

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4.34

Hennings, J; Penners, C; Lambertz, D; Trautwein, C; Sonntag, R; Liedtke, C: Genetic fine analysis of the pro-fibrotic and pro-carcinogenic functions of Cyclin E1 in the liver

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4.35

Loosen, S; Breuer, A; Tacke, F; Trautwein, C; Longerich, T; Roderburg, C; Neumann, UP; Luedde, T: Soluble urokinase plasminogen activator receptor (suPAR) predicts outcome after resection of biliary tract cancer

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4.36

Hajduk, J; Funk, K; Czauderna, C; Becker, D; Reichenbach, F; Galle, PR; Marquardt, JU; Edlich, F: The relevance of mitochondrial BAX re-distribution for apoptotic evasion in human hepatocellular carcinoma

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4.37

Albrrecht, T; Rausch, M; Rössler, S; Albrecht, M; Braun, JD; Geissler, V; Mehrabi, A; Vogel, MN; Pathil-Warth, A; Mechtersheimer, G; Renner, M; Rupp, C; Weiss, KH; Busch, E; Köhler, B; Springfeld, C; Schirmacher, P; Goeppert, B: HER2 amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis

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4.38

Kaps, L; Klefenz, A; Castven, D; Marquardt, JU; Choteschovsky, N; Khan, MA; Schuppan, D: Generation of syngeneic murine hepatoma cells bearing features of human HCC for rapid anti-HCC drug screening

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4.39

Hahn, F; Müller, L; Jungmann, F; Weinmann, A; Kloeckner, R; Mähringer-Kunz, A: Survival prediction for patients with ICC undergoing chemotherapy: comparing tumor markers to cross-sectional imaging

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4.40

Maximilian, P; Schöler, U; Kraczyk, J; Casar, C; Fründt, T; Krause, J; Werner, T; Jung, C; Ittrich, H; Lohse, AW; Felden, J von; Wege, H; Schulze, K: Real-life efficacy and safety profile of TACE in patients with intermediate HCC in a large German cohort

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4.41

Jöchle, K; Menzel, M; Herrmann, S; Fichtner-Feigl, S; Lang, SA: Impact of complexity of laparoscopic liver resections on postoperative complications

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4.42

Mester, P; Aschenbrenner, E; Kunst, C; Gülow, K; Müller-Schilling, M: Induction of apoptosis in hepatocellular carcinoma by a novel combination of histone deacetylase inhibitor LBH589

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4.43

Longerich, T; Weiss, KH; Springfeld, C; Stenzinger, A; Schirmacher, P: An umbrella concept for patients with advanced intrahepatic cholangiocarcinoma

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4.44

Ritz, T; Baues, J; Krenkel, O; Schirmacher, P; Longerich, T: Multispectral Imaging to define morpho-molecular classes of human HCC

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4.46

Pellegrino, R; Ticconi, F; Skawran, B; Castoldi, M; Schirmacher, P; Costa, I; Longerich, T: LINC00152 drives a ceRNA network in human hepatocellular carcinoma

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4.47

Kraczyk, J; Priebe, M; Schöler, U; Casar, C; Fründt, T; Krause, J; Werner, T; Jung, C; Ittrich, H; Lohse, AW; Felden, J von; Wege, H; Schulze, K: Retrospective evaluation of RFA and MWA for the treatment of HCC at the University Medical Center Hamburg 2008 – 2016

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4.48

Zhivkova, N; Ernst, I; Alizor, H; Gottfried-Brand, D; Galle, PR; Strand, D; Strand, S: Deletion of Sirtuin 6 affects tumor-directed innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

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