DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 10 · Volume 90 · 2003 DOI: 10.1055/s-008-36017

Editorial Focus

557
Imhof, Beat A.; Vadas, Mathew A.: New therapeutic targets in vascular biology
560
Taylor, Fletcher: Comment on “Drotrecogin Alfa (activated) (recombinant human protein C, rhAPC) reduces host coagulopathy response in patients with severe sepsis”
562
Semple, John W.: Platelets give us many messages
564
Miles, Lindsey A.; Ellis, Vincent: α-Enolase comes muscling in on plasminogen activation
567
Caine, Graham J.; Lip, Gregory Y. H.: Thromboembolism associated with new anti-cancer treatment strategies in combination with conventional chemotherapy: new drugs, old risks?

Review Article

570
Heissig, Beate; Werb, Zena; Rafii, Shahin; Hattori, Koichi: Role of c-kit/Kit ligand signaling in regulating vasculogenesis
577
Dormond, Olivier; Rüegg, Curzio: Regulation of endothelial cell integrin function and angiogenesis by COX-2, cAMP and Protein Kinase A
586
Cabrita, Miguel A.; Christofori, Gerhard: Sprouty proteins: antagonists of endothelial cell signaling and more
591
Nisato, Riccardo E.; Tille, Jean-Christophe; Pepper, Michael S.: Lymphangiogenesis and tumor metastasis
598
Yadav, Rashmi; Larbi, Karen Y.; Young, Rebecca E.; Nourshargh, Sussan: Migration of leukocytes through the vessel wall and beyond
607
Mach, François: Statins as novel immunomodulators: From cell to potential clinical benefit

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

611
Banfi, Cristina; Auwerx, Johan; Poma, Federica; Tremoli, Elena; Mussoni, Luciana: Induction of plasminogen activator inhibitor 1 by the PPARα ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway
620
Antovic, Jovan P.; Antovic, Aleksandra: Does recombinant factor VIIa, apart from overall hemostasis, regulate TAFI dependent fibrinolysis? In vitro analysis using overall hemostasis potential (OHP) assay
628
Hundsdoerfer, Patrick; Vetter, Barbara; Stöver, Brigitte; Bassir, Christian; Scholz, Tristess; Grimmer, Ingrid; Mönch, Eberhard; Ziemer, Sabine; Rossi, Rainer; Kulozik, Andreas E.: Homozygous and double heterozygous Factor V Leiden and Factor II G20210A genotypes predispose infants to thromboembolism but are not associated with an increase of foetal loss
636
Bertolaccini, Maria Laura; Sanna, Giovanni; Ralhan, Shvaita; Gennari, Laura C.; Merrill, Joan T.; Khamashta, Munther A.; Hughes, Graham R.V.: Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance
642
Dhainaut, Jean-François; Yan, S. Betty; Margolis, Benjamin D.; Lorente, José A.; Russell, James A.; Freebairn, Ross C.; Spapen, Herbert D.; Riess, Hanno; Basson, Bruce; Johnson III, Gerald; Kinasewitz, Gary T.; for the PROWESS Sepsis Study Group: Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
654
Zufferey, Paul; Laporte, Silvy; Quenet, Sara; Molliex, Serge; Auboyer, Christian; Decousus, Hervé; Mismetti, Patrick: Optimal low-molecular-weight heparin regimen in major orthopaedic surgery

Platelets and Blood Cells

662
Lee, Wen-Hui; Du, Xiao-Yan; Lu, Qiu-Min; Clemetson, Kenneth J.; Zhang, Yun: Stejnulxin, a novel snake C-type lectin-like protein from Trimeresurus stejnegeri venom is a potent platelet agonist acting specifically via GPVI
672
Jian-ning, Zhang; Bergeron, Angela L.; Yu, Qinghua; Sun, Carol; McBride, Latresha; Bray, Paul F.; Dong, Jing-fei: Duration of exposure to high fluid shear stress is critical in shear-induced platelet activation-aggregation
679
Hu, Hu; Varon, David; Hjemdahl, Paul; Savion, Naphtali; Schulman, Sam; Li, Nailin: Platelet-leukocyte aggregation under shear stress: Differential involvement of selectins and integrins

Wound Healing and Inflammation/Infection

688
Parsonage, Greg; Falciani, Francesco; Burman, Angela; Filer, Andrew; Ross, Ewan; Bofill, Margarita; Martin, Stuart; Salmon, Mike; Buckley, Christopher D.: Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns

Vascular Development and Vessel Remodelling

698
Bull, Todd M.; Golpon, Heiko; Hebbel, Robert P.; Solovey, Anna; Cool, Carlyne D.; Tuder, Rubin M.; Geraci, Mark W.; Voelkel, Norbert F.: Circulating endothelial cells in pulmonary hypertension
717
Mlekusch, Wolfgang; Schillinger, Martin; Exner, Markus; Sabeti, Schila; Mannhalter, Christine; Minar, Erich; Wagner, Oswald: Plasminogen activator inhibitor-1 and outcome after femoropopliteal angioplasty: analysis of genotype and plasma levels

Vascular Development and Vessel Remodeling

704
Bretschneider, Ellen; Spanbroek, Rainer; Lötzer, Katharina; Richard Habenicht, Andreas Johann; Schrör, Karsten: Evidence for functionally active protease-activated receptor-3 (PAR-3) in human vascular smooth muscle cells
710
Rezaee, Farhad; Gijbels, Marion; Offerman, Erik; Verheijen, Jan: Genetic deletion of tissue-type plasminogen activator (t-PA) in APOE3-Leiden mice reduces progression of cholesterol-induced atherosclerosis

Cellular Proteolysis and Oncology

724
López-Alemany, Roser; Suelves, Mònica; Muñoz-Cánoves, Pura: Plasmin generation dependent on α-enolase-type plasminogen receptor is required for myogenesis
734
Behrendt, Carolyn E.; Ruiz, Rolando B.: Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy

New Technologies and Diagnotic Tools

738
Bugert, Peter; Dugrillon, Alex; Günaydin, Ayse; Eichler, Hermann; Klüter, Harald: Messenger RNA profiling of human platelets by microarray hybridization

New Technologies and Diagnostic Tools

749
Fink, Ludger; Hölschermann, Hans; Kwapiszewska, Grazyna; Prakash Muyal, Jai; Lengemann, Björn; Bohle, Rainer Maria; Santoso, Sentot: Characterization of platelet-specific mRNA by real-time PCR after laser-assisted microdissection

Case Report

757
Terasawa, Fumiko; Hogan, Kelly A.; Kani, Satomi; Hirose, Masaya; Eguchi, Yutaka; Noda, Yoichi; Hongo, Minoru; Okumura, Nobuo: Fibrinogen Otsu I:A γ Asn319,Asp320 deletion dysfibrinogen identified in an asymptomatic pregnant woman

Letters to the Editor

759
Del Principe, Domenico; Frega, Gianluca; Palumbo, Giuseppe: Platelet-leukocyte interactions: platelets possess an antioxidant armamentarium
760
Germanakis, Ioannis; Stiakaki, Eftichia; Sfyridaki, Caterina; Katampekios, Spyros; Danilatou, Vasiliki; Kalmanti, Maria: Stroke in an infant heterozygous carrier of both Factor V G1691A and the G20210A prothrombin mutation