Seminars in Thrombosis and Hemostasis

Issue S 1 · Volume 32 · February 2006 DOI: 10.1055/s-002-4849 Thrombin Biology in the 21st Century: Implications in Hemostasis, Inflammation, Coagulopathies, and Cancer Harold R Roberts M.D. Earl W Davie Ph.D.

PREFACE

001

Roberts, Harold R.; Davie, Earl W.: Thrombin Biology in the 21st Century

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Davie, Earl W.; Kulman, John D.: An Overview of the Structure and Function of Thrombin

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Bode, Wolfram: The Structure of Thrombin: A Janus-Headed Proteinase

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Roberts, Harold R.; Hoffman, Maureane; Monroe, Dougald M.: A Cell-Based Model of Thrombin Generation

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039

Bunnett, Nigel W.: Protease-Activated Receptors: How Proteases Signal to Cells to Cause Inflammation and Pain

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Esmon, Charles T.: Inflammation and the Activated Protein C Anticoagulant Pathway

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061

Ruf, Wolfram; Mueller, Barbara M.: Thrombin Generation and the Pathogenesis of Cancer

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Möller, Thomas; Weinstein, Jonathan R.; Hanisch, Uwe-Karsten: Activation of Microglial Cells by Thrombin: Past, Present, and Future

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077

Hedner, Ulla: Mechanism of Action of Factor VIIa in the Treatment of Coagulopathies

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086

Bishop, Paul D.; Lewis, Kenneth B.; Schultz, Jody; Walker, Kathleen M.: Comparison of Recombinant Human Thrombin and Plasma-Derived Human α-Thrombin

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Lawson, Jeffrey H.: The Clinical Use and Immunologic Impact of Thrombin in Surgery

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