DOI : 10.1055/s-00000034

Klinische Pädiatrie

Issue 03 · Volume 221 · March 2009 DOI: 10.1055/s-002-17957


XXII. Jahrestagung der Kind-Philipp-Stiftung für Leukämieforschung
Wilsede, Lüneburger Heide, 10.–13. Juni 2009

Wissenschaftliche Leitung: Prof. Dr. H. Kabisch
Abstracts (HTML) List of Authors
A74
Vagkopoulou, R; Eckert, C; Ungethüm, U; Körner, G; Stanulla, M; zur Stadt, U; Seeger, K; Henze, G; Kirschner-Schwabe, R: Genetic characterization of high hyperdiploidy in childhood acute lymphoblastic leukemia
A1
Ambros, PF; Ambros, IM; Brodeur, GM; Haber, M; Khan, J; Nakagawara, A; Schleiermacher, G; Speleman, F; Spitz, R; London, WB; Cohn, SL; Pearson, ADJ; Maris, JM: International consensus for neuroblastoma molecular diagnostics: Report from the international neuroblastoma risk grouping (INRG) Biology committee
A2
Angerer, A; dem Knesebeck, A von; Koch, A; Waha, A; Felsberg, J; Hammes, J; Pietsch, T: Epigenetic inactivation of HHIP in brain tumors
A3
Benedikt, A; Baltruschat, S; Arrey, TN; Meyer, B; Karas, M; Bursen, A; Dingermann, T; Marschalek, R: The human AF4 and AF4·MLL multiprotein complexes provide functions in transcription and epigenetic processes
A4
Biewald, E; Mestdagh, P; Stephan, H; de Preter, K; Thor, T; Baumann, M; Lohmann, D; Eggert, A; Spelemann, F; Schramm, A; Vandesompele, J; Schulte, JH: The miR-17–92 gene cluster is amplified and overexpressed in retinoblastoma
A5
Bohrer, AM; Mahlow, E; Maurer, J; Schorle, H; Schramm, A; Eggert, A; Schulte, JH: N-myc induces transformation of neural crest stem cells in vitro and in vivo
A6
Breithaupt, P; Cario, G; Schrauder, A; Meissner, B; Moericke, A; Bourqin, JP; Schrappe, M; Stanulla, M: Early diagnosis and targeted treatment of very high-risk childhood acute lymphoblastic leukaemia
A7
Brockmeyer, B; Schulte, JH; Oberthuer, A; Mestdagh, P; Pajtler, K; Theissen, J; Bachmann, H; Hero, B; Vandesompele, J; Berthold, F; Eggert, A; Schramm, A; Fischer, M: ALK Mutation Analysis in Patients of the German Neuroblastoma Study
A8
Cin, H; Remke, M; Sturm, D; Witt, H; Wolf, S; Korshunov, A; Lichter, P; Kulozik, A; Pfister, S: Functional characterization of novel BRAF fusion gene in pilocytic astrocytomas
A9
Corbacioglu, S: The Prospective Study on the Incidence and Outcome of VOD with the Prophylactic Use of Defibrotide in Pediatric Stem Cell Transplantation has completed enrolment: Update on the VOD-DF Study
A10
Daschkey, S; Haferlach, T; Borkhardt, A; Landgraf, P: MicroRNA expression profiling in Acute myeloid leukemia patients
A11
Eberle, I; Pless, B; Braun, M; Dingermann, T; Marschalek, R: New exon/intron structures of NANOG1 and NANOG2 and their transcriptional properties in t(4;11) leukemia cells
A12
Erlacher, M; Labi, V; Bertele, D; Fischer, N; Niemeyer, CM; Villunger, A: Displacement of wild type lymphopoiesis by bone marrow cells lacking the BH3-only proteins BIM or BMF but not puma
A13
Fasan, A; Rössler, S; Löwel, D; Staege, MS; Richter, GHS; Burdach, S: Vascular mimicry and neo-angiogenesis of Ewing Tumors explored based on the identification of angiogenetic target structures
A14
Fleischmann, KK; Frowein, J von; Magg, T; Pagel, P; Albert, M; Schmid, I; Roscher, AA: MicroRNAs contribute to the leukemogenic effect of MLL-AF9
A15
Garrido Castro, P; Gessner, A; Greil, J; Vormoor, HJ; Heidenreich, O: Caspase inhibition blocks apoptosis caused by MLL-AF4 depletion in t(4;11) positive ALL cell lines, but cannot abrogate subsequent necroptosis-like cell death
A16
George, F; Hahn, G; Kuhlisch, E; Suttorp, M: Quantitative assessment of haemosiderosis of liver and spleen by MRT in children with neuroblastoma in contrast to other malignant solid tumors
A17
Gieseke, F; Handgretinger, R; Müller, I: Human multipotent mesenchymal stromal cells express different members of the galectin family with immunomodulatory functions
A18
Gondesen, I; Gieseke, F; Mang, P; Handgretinger, R; Müller, I: Specific sialylation patterns of neuroblastoma – mechanism of immune evasion?
A19
Gupta, K; Skokowa, J; Welte, K: The Association Between STAT5a Activation, LEF-1 Down Regulation and Leukemic Transformation in Patients with Severe Congenital Neutropenia
A20
Hagedorn, N; Schrauder, A; Köhler, R; zur Stadt, U; Seeger, K; Henze, G; Stackelberg, A von; Eckert, C: Is measurement of molecular response to therapy in bone marrow useful in children with isolated extramedullary relapse of acute lymphoblastic leukaemia?
A21
Hauck, F; Quick, S; Habermann, I; Bornhäuser, M; Kiani, A; Suttorp, M: NFATs take part in the expression of the immunmodulatory PGE2 by hMSCs
A22
Hauer, K; Fasan, A; Richter, GHS; Burdach, S: Influence of Ewing tumor-specific genes for the chondro-osseous phenotype and localization of this malignancy
A23
Hecker, R; Amstutz, R; Niggli, FK; Schäfer, BW: Rational combination treatment targets different aspects of PAX3/FKHR oncogenicity
A24
Heitmann, K; Reinhardt, D; Klusmann, JH: Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia
A25
Jaeger, B; Lohse, J; Navratiel, K; Rösen-Wolff, A; Suttorp, M: Impact of imatinib on in vitro osteoclastogenic differentiation of monocytes in children and adolescents with chronic myeloid leukemia.
A26
Johann, PD; Vaegler, M; Gieseke, F; Pfeiffer, M; Handgretinger, R; Müller, I: Tumor stromal cells from pediatric tumors impair NK cell function and alter NKp receptor expression
A27
Jung, R; Jacobs, U; Semper, S; Langer, T; Moericke, A; Stanulla, M; Schrappe, M; Metzler, M: Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia
A28
Kirchhoff, G; Mahlow, E; Eggert, A; Schramm, A: Characterisation of stable cell clones derived from an unusual neuroblastoma stage 4S with MYCN amplification
A29
Klusmann, JH; Godinho, FJ; Heitmann, K; Pushpanathan, T; Reinhardt, D; Orkin, SH; Li, Z: Developmental stage-specific interplay between GATA1 and IGF signaling during fetal hematopoiesis and leukemogenesis
A30
Kocak, H; Nowacki, S; Oberthuer, A; Hero, B; Kahlert, Y; Berthold, F; Fischer, M: The homeobox transcription factor HOXC9 induces growth suppression and differentiation in neuroblastoma cell lines
A31
Koch, ML; Raghavan Thangapandi, V; Reinhardt, D; Klusmann, JH: Identification of Potential Oncogenes on Chromosome 21 by RNA Interference Screening
A32
Koestner, W; Hapke, M; Klein, C; Welte, K; Sauer, M: Using the hematopoietic transplantation platform for TCR-engineered adoptive immunotherapy of leukemia
A33
Krumbholz, M; Jacobs, U; Semper, S; Goessel, H von; Langer, T; Metzler, M: Identification of first and second genomic lesions in ETV6-RUNX1 positive childhood acute lymphoblastic leukaemia (ALL)
A34
Künkele, A; Baumann, M; Odersky, A; Deubzer, H; Witt, O; Eggert, A; Schramm, A; Schulte, JH: Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitro
A35
Linka, Y; Borkhardt, A: Identification of TEL/AML1 (ETV6/RUNX1) Target Genes in Leukemogenesis
A36
Lippka, Y; Kumar Thakur, B; Lan, D; Skokowa, J; Welte, K: The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
A37
Malaise, M; Döhner, K; Reinhardt, D; Debatin, KM; Corbacioglu, S: Xenotransplant models in AML: First results of the consortium of the AML BFM Study Group
A38
Mang, P; Kruchen, A; Gondesen, I; Erbacher, A; Viebahn, S; Gieseke, F; Handgretinger, R; Müller, I: Characterisation of sialylation patterns on the surface of physiologic immune effector cells and tumour cells
A39
Meisel, R; Heseler, K; Dilloo, D; Däubener, W: Human mesenchymal stem cells exhibit dual immunosuppressive and antimicrobial effector functions – Implications for their clinical use
A41
Milde, T; Oehme, I; Pfister, S; Korshunov, A; Kopp-Schneider, A; Remke, M; Deubzer, H; Lodrini, M; Deimling, A von; Witt, O: Histone deacetylases 5 and 9 are novel markers for medulloblastoma risk stratification and potential drug targets for therapy
A42
Mühlisch, J; Schlosser, S; Wagner, S; Hasselblatt, M; Pietsch, T; Warthorst, U; Lechtape, B; Wolff, JEA; Jürgens, H; Frühwald, MC: Detection of methylation patterns in the promoter CpG-island of O6-MGMT
A43
Nebral, K; Denk, D; Attarbaschi, A; König, M; Mann, G; Haas, OA; Strehl, S: Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia
A44
Okpanyi, V; Schönberger, S; Alemazkour, A; Borkhardt, A; Schneider, DT: Wnt signalling in childhood germ cell tumors – dysregulation of extracellular Wnt inhibitors as a reason for tumor progression?
A45
Pajtler, K; Thor, T; Oles, L; Baumann, M; Heukamp, LC; Büttner, R; Kirfel, J; Schramm, A; Eggert, A; Schulte, JH: LSD1 is a Potential Therapeutic Target in Medulloblastoma
A46
Pentek, F; Kirfel, J; Lim, S; Schramm, A; Friedrichs, N; Deubzer, HE; Witt, O; Buettner, R; Eggert, A; Schulte, JH: Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells
A47
Pirson, S; Thiel, U; Bernhard, H; Richter, GHS; Burdach, S: Characterization of HLA-A*0201 restricted cytotoxic CD8+ T cells directed against ewing tumor specific antigens
A48
Pisecker, M; Arzt, L; Ullmann, R; Strehl, S: Invitation of inactivation of WT1 in pediatric T-ALL
A49
Plehm, S; Fasan, A; Rössler, S; Unland, R; Quintanilla-Martinez, L; Staege, MS; Müller-Tidow, C; Burdach, S; Richter, GHS: EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
A50
Pleier, S; Sturm, D; Remke, M; Witt, H; Goidts, V; Reifenberger, G; Felsberg, J; Kulozik, A; Korshunov, A; Lichter, P; Pfister, S: Functional characterization of SGK1 in medulloblastoma biology
A51
Pushpanathan, T; Klusmann, J; Li, Z; Böhmer, K; Godinho, FJ; Koch, ML; Orkin, SH; Reinhardt, D: Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis
A52
Queudeville, M; Eckhoff, SM; Debatin, KM; Meyer, LH: Apoptosis deficiency defines prognostic subgroups and therapy resistance in a xenograft model of pediatric BCP-ALL
A53
Remke, M; Bai, AHC; Pscherer, A; Korshunov, A; Northcott, P; Taylor, M; Lichter, P; Kulozik, A; Pfister, S: MicroRNA Signature Predicts Molecular Risk Groups in Medulloblastoma
A54
Richter, GHS; Hattenhorst, UE; Beinvogl, B; Schenk, D; Staege, MS; Burdach, S: Transcriptome analysis of pediatric cALL versus normal tissue reveals a novel signature of the malignant phenotype
A55
Romey, R; Stanulla, M; Häsler, R; Schreiber, S; Zimmermann, M; Schrappe, M; Cario, G: Expression analysis of 93 selected genes for prediction of treatment response in childhood acute lymphoblastic leukemia (ALL)
A56
Rutkowski, S; Bueren, AO von; Gerber, NU; Clifford, SC; Ellison, DW; Grotzer, MA; Hartmann, W; zur Mühlen, A; O'Toole, K; Nicholson, S; Kortmann, RD; Lannering, B; Pietsch, T: Improved Stratification of Standard Risk Medulloblastoma Patients by Clinical and Biological Prognostic Factors
A57
Schanowske, S; Lissat, A; Kontny, U: Inhibition of metastasis by overexpression of caspase-8 in a mouse xenograft model of Ewing Sarcoma
A58
Schlierf, S; Mestdagh, P; Thor, T; DePreter, K; Baumann, M; Eggert, A; Vandesompele, J; Schramm, A; Schulte, JH: Prognostic role and functional analyses of miRNA expression in neuroblastoma
A59
Schmidt, S; Tramsen, L; Hanisch, M; Huenecke, S; Koehl, U; Lehrnbecher, T: Natural Killer cells exhibit direct activity against medical important fungi
A60
Schramm, A; Schowe, B; Thor, T; Baumann, M; Dreesmann, S; Martin, M; Rahmann, S; Theissen, J; Hero, B; Morik, K; Eggert, A; Schulte, JH: Exon-level gene expression analyses of primary neuroblastoma improves risk prediction and identifies JARID1C as a candidate target
A61
Schulte, JH; Schramm, A; Thor, T; Lim, S; Pajtler, K; Kuhfittig-Kulle, S; Metzger, E; Schuele, R; Buettner, R; Kirfel, J; and Eggert, A: Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
A62
Seidel, D; Huebener, N; Pferdmenges, D; Müller, T; Wels, W; Koehl, U; Esser, R; Bleeke, M; Shibina, A; Stermann, A; Gaedicke, G; Lode, HN: NK cells engineered to express the chimeric receptor scFv(ch14.18)-zeta-specifically lyse GD2 expressing neuroectodermal tumors
A63
Shibina, A; Stermann, A; Seidel, D; Gaedicke, G; Lode, HN; Huebener, N: Establishment of a clinically applicable human tyrosine hdroxylase DNA vaccine for anti-neuroblastoma immunotherapie
A64
Skokowa, J; Lan, D; Thakur, BK; Gupta, K; Cario, G; Brechlin, AM; Stanulla, M; Welte, K: NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway.
A65
Spilger, N; Dingermann, T; Marschalek, R: A universal tool to functionally investigate different MLL fusion proteins
A66
Steiger, B; Leuschner, I; Denkhaus, D; Schweinitz, D von; Pietsch, T: Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.
A67
Stephan, H; Schulze-Dasbeck, M; Rieb, A; Grasemann, C; Lohmann, D; Eggert, A: Candidate Genes of 6p Amplification in Retinoblastoma
A68
Sturm, D; Remke, M; Pleier, S; Witt, H; Reifenberger, G; Felsberg, J; Kulozik, A; Korshunov, A; Lichter, P; Pfister, S: SGK1 expression predicts treatment response in paediatric medulloblastoma
A69
Stursberg, J; Queudeville, M; Eckhoff, SM; Debatin, KM; Meyer, LH: Gene expression profiling leads to new potential therapeutic targets for pediatric acute lymphoblastic leukemia
A70
Telieps, T; Huck, K; Feyen, O; Niehues, T; Rüschendorf, F; Hübner, N; Laws, HJ; Knapp, S; Wacker, HH; Meindl, A; Jumaa, H; Borkhardt, A: Missense mutation in the inducible T-cell kinase (ITK) leading to immunodeficiency and fatal immune dysregulation after EBV infection
A71
Terjung, S; Schulte, JH; Schlierf, S; Schramm, A; Eggert, A; Meyer, HE; Stühler, K: Proteomics of neuroblastoma master regulators
A72
Tossidou, I; Dangers, M; Brandt, DT; Koch, A; Kardinal, C: Tyrosine phosphatase SHP-2 modulates the cell cycle regulator p27Kip1 in promyelocytic leukemia cells
A73
Thor, T; Heukamp, L; Hahn, H; Kappler, R; Buettner, R; Eggert, A; Schramm, A; Schulte, JH: MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood Tumors
A75
Bueren, AO von; Shalaby, T; Oehler-Jänne, C; Pruschy, M; Rutkowski, S; Grotzer, MA: Oncogene c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells
A76
dem Knesebeck, A von; Felsberg, J; Mikeska, T; Hartmann, W; Waha, A; Endl, E; Hammes, J; Pietsch, T: RANK (TNFRSF11A) is epigenetically altered and inactivated in human gliomas
A77
Wildenhain, S; Hauer, J; Röttgers, S; Engelmann, H; Binder, V; Slany, R; Ludwig, WD; Harbott, J; Borkhardt, A: Characterization of the t(7;12) chromosomal translocation in infant AMLs: coexpression of T-cell markers, distinct expression of homeobox genes and inhibition of the non-canonical Nf-kappaB pathway
A78
Witt, H; Korshunov, A; Benner, A; Bender, S; Remke, M; Kulozik, A; Lichter, P; Pfister, S: Identification of novel predictive biomarkers and molecular targets in pediatric ependymoma
A79
Zander, AR; Lange, C; Westenfelder, C: Mesenchymal stromal cells: 1. in vitro expansion with platelet lysate, 2. in vivo administration for acute renal failure: Recovery through paracrine mechanism.