Metabolic syndrome, inflammation and atherothrombosis

Summary

Extensive research of the past decades altered our traditional concept about the genesis of atherosclerosis fundamentally. Today, the crucial role of inflammation in the formation and progression of atherosclerotic plaques is indisputable. Patients at high risk for developing cardiovascular disease, owing to poor diet, obesity and low physical activity have been shown to exhibit a particular inflammatory pattern.

Therefore, the present review highlights the crosslink between the metabolic syndrome (MetS), adipose tissue, adipokines and selected inflammatory cytokines in the context of atherothrombosis and cardiovascular disease.

Zusammenfassung

Extensives wissenschaftliches Engagement der vergangenen Jahrzehnte hat unsere Sichtweise bzgl. der Entstehung von Atherosklerose grundlegend verändert. Heute ist allgemein anerkannt, dass Entzündung diesen Prozess maßgeblich beeinflusst. Insbesondere zeigte sich bei Patienten mit einem hohen Risiko für kardiovaskuläre Erkrankungen, bedingt durch mangelnde körperliche Betätigung, Übergewicht und Fehlernährung, ein individuelles Entzündungsmuster.

Dieser Artikel beleuchtet den Einfluss von Fettgewebe, Adipokinen und pro-inflammatorischen Zytokinen auf die Entstehung von kardiovaskulären Erkrankungen in Anbetracht des metabolischen Syndroms.

Keywords

Metabolic syndrome - cardiovascular disease inflammation - atherosclerosis

Schlüsselwörter

Metabolisches Syndrom - kardiovaskuläre Erkrankungen - Entzündung - Atherosklerose

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