CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2021; 13(03): 153
DOI: 10.4103/ijmbs.ijmbs_52_21
Obituary

Prof. Taher Ahmed Rizgalla

Issam Hajjaji
1   Department of Medicine, University of Tripoli, Tripoli, Libya
› Author Affiliations
 
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Prof. Taher Ahmed Rizgalla (1936-2021)

Prof. Rizgalla, a well-known chest physician in Libya, passed away peacefully at his home in Tripoli on July 5, 2021.

Prof. Rizgalla studied undergraduate medicine at Perugia University, Italy (1958–1965), through a scholarship awarded by the Italian government. He returned to Libya a year later to work at the Tripoli Central Hospital, then left for Munich Klinikum Rechts der Isar and Perugia again 6 years later to specialize in Internal Medicine. Upon his return in 1972, he was appointed Director of the Chest Hospital at Abusitta, Tripoli.

Following the Ministry of Health's making tuberculosis (TB) as one of its priorities in 1970, Prof. Rizgalla was appointed Head of the National TB Program for Western Libya in 1973 and later Director of the TB Program for all of Libya in 1993. It was during his directorship that the WHO directly observed treatment short-course Program was implemented. This provided Bacille Calmette-Guérin vaccination at birth, Ziehl-Neelsen staining, chest radiography, free antituberculous drugs, a National Registry, and training of doctors. Under his management, the prevalence fell from 1.8% in 1959 to 0.14% in 1976. New cases continued to fall up to 1985 and remained stable until he left the program in 2003 (data thereafter were unreliable). Despite the various administrative and political challenges, he never wavered in his love for living and working in his country.

He was an active member of teaching staff at the Tripoli University Medical School for over 30 years. He finally retired from all his professional duties in 2015 for health reasons.

He is survived by his wife Ursula, daughter Jamila, sons Usama and Marwan, and 4 grandchildren.


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No conflict of interest has been declared by the author(s).

  • References

  • 1 Sedel F. Les maladies métaboliques héréditaires en neurologie adulte. Revue Neurologique 2013;169:S63-9.
  • 2 Sirrs S, Hollak C, Merkel M, Sechi A, Glamuzina E, Janssen MC, et al. The frequencies of different inborn errors of metabolism in adult metabolic centres: Report from the SSIEM adult metabolic physicians group. JIMD Rep 2016;27:85-91.
  • 3 Przyrembel H, Wendel U, Becker K, Bremer HJ, Bruinvis L, Ketting D, et al. Glutaric aciduria type II: Report on a previously undescribed metabolic disorder. Clin Chim Acta 1976;66:227-39.
  • 4 Frerman FE, Goodman SI. Defects of electron transfer flavoprotein and elec-tron transfer flavoprotein-ubiquinone oxidoreductase: Glutaric aciduria type II. In: The Metabolic and Molecular Bases of Inherited Disease. Vol. 8. New York: McGraw-Hill; 2001. p. 2357e65.
  • 5 Olsen RK, Andresen BS, Christensen E, Bross P, Skovby F, Gregersen N. Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency. Hum Mutat 2003;22:12-23.
  • 6 Gregersen N, Andresen BS, Corydon MJ, Corydon TJ, Olsen RK, Bolund L, et al. Mutation analysis in mitochondrial fatty acid oxidation defects: Exemplified by acyl-CoA dehydrogenase deficiencies, with special focus on genotype-phenotype relationship. Hum Mutat 2001;18:169-89.
  • 7 Ozand PT, Gascon GG. Organic acidurias: A review. Part 1. J Child Neurol 1991;6:196-219.
  • 8 Vianey-Liaud C, Divry P, Gregersen N, Mathieu M. The inborn errors of mitochondrial fatty acid oxidation. J Inherit Metab Dis 1987;10 Suppl 1:159-200.
  • 9 Turnbull DM, Bartlett K, Eyre JA, Gardner-Medwin D, Johnson MA, Fisher J, et al. Lipid storage myopathy due to glutaric aciduria type II: Treatment of a potentially fatal myopathy. Dev Med Child Neurol 1988;30:667-72.
  • 10 Mongini T, Doriguzzi C, Palmucci L, De Francesco A, Bet L, Manfredi L, et al. Lipid storage myopathy in multiple acyl-CoA dehydrogenase deficiency: An adult case. Eur Neurol 1992;32:170-6.
  • 11 Morris AA, Spierkoetter U. Disorders of mitochondrial fatty acid oxidation and related metabolic pathways. In: Saudubray JM, van den Berghe G, Walter JH, editors. Inborn Metabolic Diseases. 5th ed. Heidelberg: Springer-Verlag Berlin; 2011.
  • 12 Ersoy E, Rama D, Ünal Ö, Sivri S, Topeli A. 2015. Glutaric aciduria type 2 presenting with acute respiratory failure in an adult. Res Med Case Rep 2015;15:92-4.
  • 13 Dusheiko G, Kew MC, Joffe BI, Lewin JR, Mantagos S, Tanaka K, et al. Recurrent hypoglycaemia associated with glutaric aciduria type II in an adult. N Engl J Med 1979;301:1405-9.
  • 14 Gregersen N, Kolvraa S, Rasmussen K, Christensen E, Brandt NJ, Hansen FH, et al. Biochemical studies in patients with defects in acyl-CoA metabolism and sarcosine metabolism: Another possible case of glutaric aciduria type II. J Inherit Metab Dis 1980;3:67-72.
  • 15 al-Essa MA, Rashed MS, Bakheet SM, Patay ZJ, Ozand PT. Glutaric aciduria type II: Observations in seven patients with neonatal- and late-onset disease. J Perinatol 2000;20:120-8.
  • 16 de Visser M, Scholte HR, Schutgens RB, Bolhuis PA, Luyt-Houwen IE, Vaandrager-Verduin MH, et al. Riboflavin-responsive lipid-storage myopathy and glutaric aciduria type II of early adult onset. Neurology 1986;36:367-72.
  • 17 Liang WC, Ohkuma A, Hayashi YK, Lopez LC, Hirano M, Nonaka I, et al. ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase efficiency. Neuromuscular Disord 2009;19:212e6.
  • 18 Roe CR, Coates PM. Mitochondrial fatty acid oxidation disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle PD. editors. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw Hill Inc.; 1995. p. 1501-33.
  • 19 Mooy PD, Przyrembel H, Giesberts MA, Scholte HR, Blom W, van Gelderen HH. Glutaric aciduria type II: Treatment with riboflavine, carnitine and insulin. Eur J Pediatr 1984;143:92-5.

Corresponding author

Prof. Issam Mehdi Hajjaji
Department of Medicine, University of Tripoli
Tripoli
Libya   
Email: issam@dr.com   

Publication History

Received: 12 July 2021

Accepted: 13 July 2021

Article published online:
14 July 2022

© 2021. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Sedel F. Les maladies métaboliques héréditaires en neurologie adulte. Revue Neurologique 2013;169:S63-9.
  • 2 Sirrs S, Hollak C, Merkel M, Sechi A, Glamuzina E, Janssen MC, et al. The frequencies of different inborn errors of metabolism in adult metabolic centres: Report from the SSIEM adult metabolic physicians group. JIMD Rep 2016;27:85-91.
  • 3 Przyrembel H, Wendel U, Becker K, Bremer HJ, Bruinvis L, Ketting D, et al. Glutaric aciduria type II: Report on a previously undescribed metabolic disorder. Clin Chim Acta 1976;66:227-39.
  • 4 Frerman FE, Goodman SI. Defects of electron transfer flavoprotein and elec-tron transfer flavoprotein-ubiquinone oxidoreductase: Glutaric aciduria type II. In: The Metabolic and Molecular Bases of Inherited Disease. Vol. 8. New York: McGraw-Hill; 2001. p. 2357e65.
  • 5 Olsen RK, Andresen BS, Christensen E, Bross P, Skovby F, Gregersen N. Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency. Hum Mutat 2003;22:12-23.
  • 6 Gregersen N, Andresen BS, Corydon MJ, Corydon TJ, Olsen RK, Bolund L, et al. Mutation analysis in mitochondrial fatty acid oxidation defects: Exemplified by acyl-CoA dehydrogenase deficiencies, with special focus on genotype-phenotype relationship. Hum Mutat 2001;18:169-89.
  • 7 Ozand PT, Gascon GG. Organic acidurias: A review. Part 1. J Child Neurol 1991;6:196-219.
  • 8 Vianey-Liaud C, Divry P, Gregersen N, Mathieu M. The inborn errors of mitochondrial fatty acid oxidation. J Inherit Metab Dis 1987;10 Suppl 1:159-200.
  • 9 Turnbull DM, Bartlett K, Eyre JA, Gardner-Medwin D, Johnson MA, Fisher J, et al. Lipid storage myopathy due to glutaric aciduria type II: Treatment of a potentially fatal myopathy. Dev Med Child Neurol 1988;30:667-72.
  • 10 Mongini T, Doriguzzi C, Palmucci L, De Francesco A, Bet L, Manfredi L, et al. Lipid storage myopathy in multiple acyl-CoA dehydrogenase deficiency: An adult case. Eur Neurol 1992;32:170-6.
  • 11 Morris AA, Spierkoetter U. Disorders of mitochondrial fatty acid oxidation and related metabolic pathways. In: Saudubray JM, van den Berghe G, Walter JH, editors. Inborn Metabolic Diseases. 5th ed. Heidelberg: Springer-Verlag Berlin; 2011.
  • 12 Ersoy E, Rama D, Ünal Ö, Sivri S, Topeli A. 2015. Glutaric aciduria type 2 presenting with acute respiratory failure in an adult. Res Med Case Rep 2015;15:92-4.
  • 13 Dusheiko G, Kew MC, Joffe BI, Lewin JR, Mantagos S, Tanaka K, et al. Recurrent hypoglycaemia associated with glutaric aciduria type II in an adult. N Engl J Med 1979;301:1405-9.
  • 14 Gregersen N, Kolvraa S, Rasmussen K, Christensen E, Brandt NJ, Hansen FH, et al. Biochemical studies in patients with defects in acyl-CoA metabolism and sarcosine metabolism: Another possible case of glutaric aciduria type II. J Inherit Metab Dis 1980;3:67-72.
  • 15 al-Essa MA, Rashed MS, Bakheet SM, Patay ZJ, Ozand PT. Glutaric aciduria type II: Observations in seven patients with neonatal- and late-onset disease. J Perinatol 2000;20:120-8.
  • 16 de Visser M, Scholte HR, Schutgens RB, Bolhuis PA, Luyt-Houwen IE, Vaandrager-Verduin MH, et al. Riboflavin-responsive lipid-storage myopathy and glutaric aciduria type II of early adult onset. Neurology 1986;36:367-72.
  • 17 Liang WC, Ohkuma A, Hayashi YK, Lopez LC, Hirano M, Nonaka I, et al. ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase efficiency. Neuromuscular Disord 2009;19:212e6.
  • 18 Roe CR, Coates PM. Mitochondrial fatty acid oxidation disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle PD. editors. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw Hill Inc.; 1995. p. 1501-33.
  • 19 Mooy PD, Przyrembel H, Giesberts MA, Scholte HR, Blom W, van Gelderen HH. Glutaric aciduria type II: Treatment with riboflavine, carnitine and insulin. Eur J Pediatr 1984;143:92-5.

Zoom Image
Prof. Taher Ahmed Rizgalla (1936-2021)