Key-words:
Calvarial - primary intraosseous cavernous hemangiomas - skull
Introduction
Cavernous hemangiomas of the calvarium are rare benign tumors that account for ~ 10%
of benign skull tumors.[[1]] They are most frequently found in parietal and frontal bones of the skull. Calvarial
hemangiomas are usually small and remain as slow-growing asymptomatic lesions. They
may become symptomatic if they grow in size and become palpable tender swellings over
the scalp. En bloc surgical resection is the treatment of choice and the prognosis
after a complete excision that is excellent and recurrence is usually rare. We present
a rare case of a giant cavernous hemangioma of the skull. The clinical presentation,
pathology, differential diagnosis, and treatment of this rare disorder are discussed.
Case Report
A 32-year-old female patient presented with complaints of swelling over the right
side of the skull for 3 years. The swelling was gradually increasing in size. On examination,
a 10 cm × 14 cm swelling noted over the right parietal region. Skin over the swelling
is freely mobile. The swelling is hard in consistency and nontender. No bruit heard
over swelling. Neurological examination was normal.
Computed tomography (CT) of the brain revealed a hyperdense osteolytic lesion within
the diploe on the right parietal bone with a characteristic spoke-wheel pattern [[Figure 1]]a. The lesion was hyperintense on both T1-weighted (T1W1) [[Figure 2]]a and [[Figure 2]]b and T2W1 [[Figure 1]]b images with the enhancement on contrast administration.
Figure 1: (a and b) Computed tomography of the brain revealed a hyperdense osteolytic lesion
within the diploe on the right parietal bone with a characteristic "spoke-wheel" or
"honeycomb" pattern
Figure 2: (a) Magnetic resonance imaging of brain T1-weighted images showing hyperintense extra-axial
lesion in the right parietal region. (b) Magnetic resonance imaging of brain T2-weighted
images showing hyperintense extra-axial lesion in the right parietal region
The patient was evaluated for primary malignancy elsewhere in the body and found to
be negative.
The patient was planned for surgery. She was kept in the supine position with head
turned to the left side. Horse-shoe shaped incision was given over the right fronto-parietal
region and the flap was raised. Bony swelling was exposed with surrounding normal
bone. A right parietal craniectomy and total lesion resection with a margin of surrounding
normal bones were done under general anesthesia. During surgery, the tumor was found
to be intraosseous, the outer table was thin and the inner table was eroded by the
tumor, which was entirely extradural and extremely vascular causing a significant
intraoperative bleeding [[Figure 3]]a and [[Figure 3]]b. Postoperative recovery of the patient was uneventful. Histopathological examination
confirmed the diagnosis of cavernous hemangioma [[Figure 4]].
Figure 3: (a and b) Intraoperative photographs showing expansion of diploe and erosion of inner
table of the skull
Figure 4: Photomicrograph of h and e stained preparation showing bony trabeculae with a lesion
comprising of multiple large thin-walled lattice pattern of vessels, lined by thin
endothelium
Discussion
Primary intraosseous cavernous hemangiomas (PICHs) are benign vascular malformations
that account for approximately 0.2% of all bone tumors and 10% of benign skull tumors.[[1]] Hemangiomas are histologically classified in to three subtypes, namely, cavernous,
capillary, and mixed type. Cavernous hemangiomas are characterized by the clusters
of dilated blood vessels separated by fibrous septa in contrast to capillary hemangiomas
which consist of small vascular lumens without much fibrous septa. Cavernous hemangiomas
are more common in the skull, whereas the capillary type is more common in the vertebral
column.
Calvarial cavernous hemangiomas are more common in the frontal bone followed by parietal,
temporal, and occipital bones. Cavernous hemangiomas very rarely involve the skull
base. Cavernous hemangioma of the skull arises from the vessels in the diploic space
and is supplied by the branches of the external carotid artery. The middle and superficial
temporal arteries are the main sources of the blood supply.[[2]],[[3]] Pathogenesis of calvarial hemangiomas is not yet known fully. They are considered
to be congenital. Proliferation and differentiation of the undifferentiated primitive
mesenchymal cells induced by the various stimuli-like traumas may be the potential
etiology. The most commonly affected age group is 40–70 years.[[4]] The female-to-male ratio is 2:1–3:1.[[5]] Calvarial hemangiomas are usually small and remain as slow-growing asymptomatic
lesions. They may become symptomatic if they grow in size and become palpable tender
swellings over the scalp. Calvarial hemangiomas may become symptomatic if they compress
adjacent structures.[[6]] Two types of growth patterns have been described. The first type is a “sessile”
pattern that grows along the dipole, and the second is a “globular” pattern which
arises from the skull base and presents as a space-occupying lesion.[[7]]
Calvarial hemangiomas usually involve the outer table of the skull. Extensive involvement
of the inner table and dura are usually rare.[[8]]
The investigation of choice is CT scan which classically depicts lytic expansile and
bubbly lesion with a sclerotic rim also known as “sunburst” or “spoke-wheel” appearance.
CT also helps in delineating the extent of tumor in to surrounding structures. Magnetic
resonance imaging (MRI) signal intensity depends on the amount of venous stasis in
the lesion and also on the rate of red bone marrow in to yellow marrow. T1W1 images
have high-or-low intensity signals. T2W1 and fluid-attenuated inversion recovery show
high-signal intensity.[[9]],[[10]]
The lesions enhance on contrast administration intensely on both CT and MRI.
Histopathology of cavernous hemangioma shows unencapsulated dilated sinusoidal channels
that are lined by a single layer of flattened endothelium and are interspersed among
bony trabeculae.
The other differential diagnosis of intradiploic skull masses includes eosinophilic
granulomas, aneurysmal bone cysts (ABCs), dermoid tumors, metastatic deposits, meningiomas,
sarcomas, and Langerhans cell histiocytosis.[[11]],[[12]]
CT findings of various pathological lesions in differential diagnosis of a skull tumor
are as follows.
CT scan of Langerhans cell histiocytosis shows a lytic defect with “beveled” edges
(inner Table > outer Table) and a soft-tissue mass within the defect. No periosteal
reaction is seen. Soft tissue in the lytic defect enhances on contrast administration.
Patients with eosinophilic granuloma are usually <5 years of age. CT scan shows a
lesion with beveled edges. Hole–within – a hole/button sequestrum appearance is seen.
Patients with metastasis deposits in the skull are usually older; often have a history
of cancer. CT imaging shows hemorrhagic hyper intensity, with a contrast enhancing
mass centered in the bone with osseous destruction lacking “benign” sclerotic border.
Dermoid cyst shows a well-defined round hypodense unilocular cystic mass on CT imaging,
which expands the diploe. There will be no enhancement on contrast administration.[[13]] CT imaging of ABC shows sharply-defined expansile osteolytic lesion with thin sclerotic
margins. Multiple fluid levels which represent sedimentation of red blood cells within
blood filled cavities will be seen.[[14]] Intradiploic meningioma may be osteoblastic ~ 65% or osteolytic ~ 35%. The osteolytic
subtype has to be differentiated from calvarial hemangioma. Osteolytic subtype is
seen as expansile lytic lesion of the skull involving the inner and outer tables with
thinning of both tables. Intense contrast enhancement is usually seen.[[15]]
Preoperative diagnosis of cavernous hemangiomas is often difficult because imaging
findings are not specific. Histopathological examination is often necessary to confirm
the diagnosis.
En bloc surgical resection with normal bone margins is the treatment of choice for
PICH of the skull.[[16]] Embolization before surgery is helpful to reduce the blood loss in large lesions.
Radiotherapy can prevent the tumor growth but does not cure the lesion.
Conclusion
Calvarial cavernous hemangiomas are rare benign skull tumors. They most frequently
involve parietal and frontal bones of the skull. They are slow-growing asymptomatic
lesions. They may become symptomatic if they attain a large size or compress adjacent
structures. Complete tumor excision with normal bony margins is the treatment of choice.
Radiological features may not be classic sometimes and may mimic other skull tumors.
Histopathological confirmation of tumor is the definitive method for the diagnosis
of calvarial cavernous hemangioma. These lesions should always be considered in the
differential diagnosis of skull tumors because surgery provides definitive cure for
the disease.
Declaration of patient consent
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In the form the patient(s) has/have given his/her/their consent for his/her/their
images and other clinical information to be reported in the journal. The patients
understand that their names and initials will not be published and due efforts will
be made to conceal their identity, but anonymity cannot be guaranteed.
