Open Access
CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(02): 285-292
DOI: 10.4103/ajns.AJNS_120_19
Original Article

Histopathological pattern and outcome of posterior fossa tumors in children and adults – A 20-year experience

Abdul Bhat
Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
,
Muhammed Wani
Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
,
Altaf Kirmani
Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
› Author Affiliations
 

Context: The postoperative quality and span of life in posterior fossa tumors (PFTs) is complicated by the residual disease, progression, recurrence, disabilities, and mortality. Aims: The aim of this study is to analyze the link between histopathological type of tumor and outcome in an ethnic Himalayan population of India. Settings and Design: The histopathological records of 410 out of 589 patients were compared with their clinical outcome up to the 1st postoperative year in a single center which amounts to regional epidemiological value of PFTs. Materials and Methods: In this observational study, retrospectively postoperative records of 589 PFTs from November 1990 to December 2010 (20 years) were retrieved, scrutinized, and observed. The postoperative records of 410 patients with proved histopathological examination results were included. Statistical Analysis Used: The statistical law of variance was applied wherever necessary. Results: About 63.2% of 410 operated PTFs were males while females predominated in meningiomas and pineoblastomas. About 31.7% of PFTs were children (below 18 years.). About 54.1% of the cases were histologically malignant. The residual tumors comprised 40.2%, and symptoms of disease progression occurred in 10.9%. The tumor recurrence occurred in 14.3% while 6.0% of the patients developed severe disability. The overall mortality was 11.4% up to the 1st postoperative year, with 18.9% in malignant patients. The first 1-year event-free survival (EFS) for all the patients was 66.0%. While the patients with malignancies had the first 1-year EFS of 47.7%, the histologically benign group had 87.7%. Conclusion: The first 1-year postoperative EFS of histologically benign and some malignant PFTs both in children and adults such as pilocytic astrocytomas, ependymomas, and pineoblastomas was much better (87.7%) than other malignant PTFs.


Introduction

The triad of anatomically tight-spaced posterior fossa, presence of biologically active tumor, and obstructive hydrocephalus are the predictors of the worse outcome in PFTs. The posterior fossa of the cranial cavity, limited by the tentorium above, also called infratentorial space, has much smaller space than the rest of the cranial cavity. However, the contents of such a comparably small space are several types of motor and sensory tracts and a number of vital nuclei and reticular formation for the systemic body functions and consciousness in the form of midbrain, pons, and medulla. Also packed are cranial nerves, vascular network with large venous sinuses, changing volume of cerebrospinal fluid (CSF) in the ventricle and cisterns, and prominently visible cerebellar parenchyma with nuclei and peduncles. Most of the times, the posterior fossa tumors (PFTs) present themselves as an acute emergency following the compression of the brainstem either due to the increase in tumor size, edema, bleed, or obstruction to CSF pathways and herniation. The surgical debulking, to relieve the pressure on the brainstem, though full of risks, is an indispensable mode of management. However, in such a small space, the intraoperative complications and postoperative disease progression owing to residual or recurrence of the lesion worsen the surgical outcome. In 1930, an account of 61 patients of PFTs was published by the most cherished neurosurgeon of the world, Cushing H, claiming fatal outcome in almost all.[[1]] The present study emphasizes the significance of histological identification to the surgical outcome.


Materials and Methods

Literally of epidemiological value, this observational study took into account the records of those patients who were treated in the past and did not need to identify themselves to the researchers. Since the study was mainly a compilation of surgical and histopathological records wherein neither institutional review board/ethical approval nor patient consent was required, it provided epidemiological data about the disease and a particular population because the population group is mainly mountain locked, ethnic, and nonmigratory. It benefited the medical and community health census directly. It was conducted on all operated patients of PTFs admitted from November 1990 to December 2010 (20 years) in the division of neurosurgery. The neurosurgical patients are managed with a standard and uniform protocol. Retrospectively records of all the 589 patients of PFTs were retrieved from the files in the medical records department, operation theatre register, outpatient department files, referral clinics, and follow-up files of the supportive departments such as medical and radiation oncology and pathology of this tertiary health-care facility. The information about the patient's biodata, history, examination, basic routine biochemical and hematological investigations, all the imaging (computed tomography [CT], magnetic resonance imaging [MRI]), surgical procedures, intraoperative (frozen/crush) histopathological reports, final histopathological examination reports, postoperative follow-up notes, and imaging records (CT and MRI) up to the first 1 year of only 410 patients were included and recorded. The data were analyzed, compiled, and conclusions drawn. The statistical law of variance was applied wherever necessary.


Results

The results of the study revealed a male predominance of 63.2% (259/410) of the cases in overall PFTs with a M/F ratio of 1.7:1.0 [[Table 1]]. About 31.7% (130/410) of all the PFTs were found in the children (age = 18 years and below). The most commonly occurring PFTs in children were medulloblastomas (more of a classical variety) (84.7%, 61/72). However, various tumors such as schwannomas (2.9%, 3/102) and meningiomas (2.6%, 1/38) were uncommonly found in children while metastases not at all. The results revealed that the vestibular schwannoma [[Figure 1]] at the rate of 23.9% (98/410) was the most occurring individual PFT. The most common histopathology of the PFTs was the malignancy occurring in 54.1% (222/410) of the cases [[Table 1]] and [[Table 2]]. The medulloblastoma (histologically classical) was the most common (32.4%, 72/222) malignant PFT. The histological types of PFTs and the 1-year postoperative outcome showed a significant relation. Comparatively, the histologically benign PFTs had only 18.6% (35/188) of the patients left with residual lesions. The symptoms of disease progression were found in 5.1% (5/98) of the patients of vestibular schwannomas and 14.2% (4/28) of hemangioblastomas [[Figure 2]]. The event-free survival (EFS) of hemangioblastomas was 85.7% (24/28), dermoids 100% (15/15), and epidermoids 88.8% (8/9) [[Figure 3]] in the 1st postoperative year. The postoperative residual tumor on imaging was found in 70.2% (33/47) of the patients of high-grade astrocytomas, 66.6% (6/9) with metastatic lesions, 62.5% (15/24) with pilocytic astrocytomas, 43.0% (31/72) with medulloblastomas [[Figure 4]] and [[Figure 5]], and 41.8% (18/43) with ependymomas [[Figure 6]]. The highest tumor recurrences of 100% (4/4) were noted in malignant meningiomas (anaplastic and rhabdoid variants), 56.2% (9/16) in brainstem gliomas, 55.5% (5/9) in metastatic lesions, 42.8% (3/7) in pineoblastomas, and 19.4% (14/72) in medulloblastomas. The severe disability was more often seen in the brainstem gliomas owing to their long survival, decubitus ulcers, and respiratory system infections. However, there was no EFS in any case of malignant meningioma, which simultaneously had the highest mortality of 75.0% (3/4). The mortality in metastatic lesions was 66.6% (6/9), brainstem gliomas 43.7% (7/16), and medulloblastomas 30.5% (22/72). There was no mortality found in pinealoblastomas and pilocytic astrocytomas, although in a postoperative year, ependymoma had a lower mortality of 6.9% (3/43) and high-grade astrocytomas 2.1% (1/47).

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Table 1: Histopathology, sex, and postoperative outcome in posterior fossa tumors
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Figure 1: A patient of left cerebello.pontine angle vestibular schwannoma; Intraoperative photos in sitting position and post-operative axial magnetic resonance imaging with histopathological photograph (H and E; ˣ40)
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Table 2: Surgical outcome related to histopathological types of tumors in posterior fossa
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Figure 2: Two (Sibling) patients of hemangioblastomas; shows Imaging, resected specimen and histological photograph (H and E; x400). The large serpentinous vessel supplying the intramural nodule as viewed on magnetic resonance images, in the lower row, is seen on intraoperative photograph
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Figure 3: Computed tomography scan, magnetic resonance images, intraoperative photographs in sitting position and tumor specimen of a cerebello-pontine angle Epidermoid with histopathological microphotograph
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Figure 4: An 8 years male child with medulloblastoma shows radio-imaging and intraoperative pictures. Histopathological images show infiltrating tumor cells invading cerebellar cortex (H and E; x20)
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Figure 5: Adult medulloblastoma; depicts computed tomography and magnetic resonance images, intraoperative photographs in sitting position and postoperative computed tomography scan at day fourth. The histopathological micrograph shows moderate anaplasia (H and E; ˣ100)
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Figure 6: Magnetic resonance images and intraoperative photographs of an ependymoma of 4th ventricle (WHO Grade II). The aqueduct of sylvius is seen opening inside the fourth ventricle. Low power microphotograph shows the histopathological view of the tumor

Discussion

The present study observed that 31.7% of the patients were children (18 years and below). Histopathologically malignancy featured in most (54.1%) of the patients while benign tumors occurred in 45.8% of the patients [[Table 1]] and [[Table 2]]. A research study in 1997 revealed that out of the 1000 vestibular schwannoma tumors operated in 962 patients, 2.1% of the patients had residual tumors, 1.1% of the patients had severe neurological disability, 5.5% of the patients had caudal cranial nerve palsies, and 1.1% had mortality.[[2]] Seol et al., in 2006, analyzed 116 patients of vestibular schwannomas where the residual tumor was seen in 77.5% and the recurrence in 17.2%. The gross total resection (GTR) was the best approach to avoid the recurrence.[[3]] Yamakami et al., in 2004, revealed 14% residual tumor, 4% neurodeficit, and no mortality in 50 operated patients of vestibular schwannomas.[[4]] The present study observed 50% of residual tumors in trigeminal schwannomas and 23.4% in vestibular schwannomas. About 2.9% of schwannomas were found in children. Roberti et al., 2001, wrote that 161 patients of posterior fossa meningiomas were operated over a period of 9 years with residual tumors found in 43% of the patients, progression of disease and recurrence in 13.7%, and mortality in 2.5%.[[5]] The researchers, in 2012, showed postoperative results of 64 patients of posterior fossa meningiomas, where recurrence occurred in 15.6% of the patients, severe neurological deficits in 33%, hydrocephalus in 43.75%, and mortality in 3.2%.[[6]] Hakuba et al. reported 17% mortality and severe neurological deficits in 83% of the patients in radical excision of clival meningiomas of the posterior fossa.[[7]] Couldwell et al. studied 40 males and 69 females, a male–female ratio of 1:1.7, with posterior fossa (petroclival) meningiomas postoperatively in which gross total excision was achieved in 69% of the patients and 13% had recurrence or progression of disease.[[8]] Louis et al. reported a 5-year progression-free survival of approximately 50%.[[9]] The present analysis showed almost similar results. Hemangioblastomas are uncommon highly vascular, well-circumscribed, <3% of all central nervous system tumors, mostly (7.5%) in adult cerebellum and brainstem.[[10]] The present study found an incidence of 6.8% for hemangioblastomas [[Figure 2]], including two sisters in a family. The research found an EFS of 85.7% in the 1st postoperative year. Dermoid cysts represent a rare clinical entity that accounts for 0.1%–0.7% of all brain tumors.[[11]] This study observed that the dermoids comprised 3.6% of all the PFTs. The EFS of dermoids was 100% in the 1st postoperative year. Epidermoids, also known as cholesteatomas, are pearly tumors and account for approximately 0.1% of all intracranial tumors growing by the desquamation of the cyst wall and accumulation of keratin and cholesterol.[[12]] Zakrzewski et al. studied 216 children with PTFs below the 18th year of age, which depicted male/female ratio of 1.35:1.00. The most common tumor was pilocytic astrocytoma – 41.5%; medulloblastoma – 34.5%; ependymomas – 13%, and mixed neuronal–glial tumors – 5.5%.[[13]] Muzumdar et al., in 2011, presented 154 patients (age <18 years) of medulloblastoma noting 92.2% (142 cases) had classical medulloblastoma and 5.1% (8 cases) had desmoplastic variant. The 5- and 10-year progression-free survival rate was 73% and 41%, respectively, for average-risk disease, while for high-risk disease, it was 34%.[[14]] Rutka 1997 noted that medulloblastomas are intracranial childhood neoplasm, accounting for 25% of all childhood tumors.[[15]] Furthermore, Bloom and Bessell in 1990 showed that medulloblastomas in adults account for <1% of all adult brain tumors.[[16]] Chan et al., in 2000, found in a study that the recurrence rate for medulloblastomas in adults is approximately 50%–60%. The median time-to-tumor progression and recurrence is approximately 30 months after treatment.[[17]] In the present study, medulloblastomas [[Figure 4]] and [[Figure 5]] were found in 17.5% of the patients mostly (84.7%) in children. The postoperative residual tumor was found in 43.0% and recurrence in 19.4%. A mortality of 30.5% occurred in the 1st-postoperative year. Djalilian and Hall reported that 53% of the patients in a study had Grade IV malignant cerebellar gliomas and 47% had anaplastic Grade III astrocytomas.[[18]] The present study observed that 11.4% of PFTs had high-grade anaplastic and glioblastoma type of malignant cerebellar astrocytomas. The postoperative residual tumor was found in 70.2%, and an EFS of 31.9% in the 1st postoperative year was observed with a mortality of 2.1%. Witt et al. 2011 reported that the posterior fossa ependymomas comprise two distinct molecular entities, ependymoma posterior fossa A (EPN PFA), and EPN PFB, with differentiable gene expression profiles.[[19]] In the present study, ependymoma [[Figure 6]] had residual tumors in 41.8% and recurrence in 11.6%. The EFS of 51.1% and a mortality of 6.9% were found in the 1st postoperative-year. Desai et al., 2001, reported that the pilocytic cerebellar astrocytomas comprise 25% of all PFTs in children.[[20]] Following up 104 children with cerebellar juvenile pilocytic astrocytomas over a mean period of 8.3 years, Daszkiewicz et al., 2009, found that 57.6% (60/104) of the patients had permanent neurological deficits while 47 had significant behavioral disorders.[[21]] A study by Lesniak et al. 2003 observed that among 57 patients of brainstem gliomas, 29 had a total surgical resection, 8 a near-total resection (> 90%), 15 a subtotal resection (STR) (50%–90%), and 5 a partial resection (<50%). The progression-free survival of all patients was 71.9% at 3 years and 45.6% at 5 years.[[22]] Donaldson et al., 2006, reported a high rate of recurrence or progression and often followed an inexorable course of progression, despite therapy.[[23]] All brainstem gliomas in the present study had postoperative residual lesions, and 37.5% had progression of disease and 56.2% recurrence. The severe disability in the brainstem gliomas, in the present study, was more often linked to the long survival, motor dysfunction, decubitus ulcers, and respiratory system infections caused by the early involvement of lower cranial nerves and the long tracts by these low-grade tumors. These had a mortality of 43.7% and an EFS of 31.2%. Sunderland et al., 2016 reported that overall 80% of the patients underwent GTR, 14% underwent STR, and 6% underwent biopsy of the metastatic posterior fossa. The median overall survival was 6.00 months. The 28-day mortality was 7.6% (n = 7), with a perioperative morbidity of 22.8% (n = 21).[[24]] Zhang et al., 2012, observed that the most common primary site of malignancy for brain metastasis was lung (20%–40%), followed by breast(5%–17%) and melanoma (7%–11%) with renal, colorectal, and gynecological cancers making up the majority of the remaining.[[25]] The present series of 410 PFTs also consisted of 2.1% of the patients of metastatic deposits, mostly from primaries such as carcinoma lung, carcinoma breast, renal cell carcinoma, and malignant melanoma. Tate et al., in 2012, suggested an increase in survival of pineoblastomas with increasing degrees of resection by observing a 5-year survival rate of 84% for patients who underwent GTR versus 53% for patients who underwent STR and 29% for patients who underwent debulking.[[26]] Pineoblastomas in this study comprised 1.7% of all PFTs while 57.1% of these were children. Roberti et al., 2001, reported 5% malignant meningiomas in a study of 161 patients.[[5]] However, Wang et al., 2016, reported that about 51% of the patients experienced recurrences. The relapse-free survival at 12 months was 84.3% and at 5 years was 57.8%.[[27]] Of 410 PFTs presently, 0.97% had malignant meningiomas (WHO Grade III), mostly rhabdoid and anaplastic, which formed 10.6% of all PTFs with a recurrence of 100% and mortality of 75.0%.


Conclusion

The present study of PFTs in children and adults, of an ethnic nonmigratory Himalayan-population of India, is of regional epidemiological value. Given the aggressive biological behavior, the histologically proven malignant lesions in posterior fossa have all the opportunities to harm the vitality of posterior fossa structures and lead to catastrophic outcome pre-, intra-, and postoperatively.



Conflict of Interest

There are no conflicts of interest.

Acknowledgements

We thank Aisha Jr., Huwa, Nancy, Aisha Sr., Saim-Ul, Roh-Ul, Abul-Adam, and Maqbool-Abu for their sincere help and sincerity.

Financial support and sponsorship

Nil.


  • References

  • 1 Cushing H. Experience with the cerebellar medulloblastoma: Critical review. Acta Pathol Microbiol Immunol Scand 1930;7:1-86.
  • 2 Samii M, Matthies C. Management of 1000 vestibular schwannomas (acoustic neuromas): Surgical management and results with an emphasis on complications and how to avoid them. Neurosurgery 1997;40:11-21.
  • 3 Seol HJ, Kim CH, Park CK, Kim CH, Kim DG, Chung YS, et al. Optimal extent of resection in vestibular schwannoma surgery: Relationship to recurrence and facial nerve preservation. Neurol Med Chir (Tokyo) 2006;46:176-80.
  • 4 Yamakami I, Uchino Y, Kobayashi E, Yamaura A, Oka N. Removal of large acoustic neurinomas (vestibular schwannomas) by the retrosigmoid approach with no mortality and minimal morbidity. J Neurol Neurosurg Psychiatry 2004;75:453-8.
  • 5 Roberti F, Sekhar LN, Kalavakonda C, Wright DC. Posterior fossa meningiomas: Surgical experience in 161 cases. Surg Neurol 2001;56:8-20.
  • 6 Velho V, Agarwal V, Mally R, Palande DA. Posterior fossa meningioma “our experience” in 64 cases. Asian J Neurosurg 2012;7:116-24.
  • 7 Hakuba A, Nishimura S, Tanaka K, Kishi H, Nakamura T. Clivus meningioma: Six cases of total removal. Neurol Med Chir (Tokyo) 1977;17:63-77.
  • 8 Couldwell WT, Fukushima T, Giannotta SL, Weiss MH. Petroclival meningiomas: Surgical experience in 109 cases. J Neurosurg 1996;84:20-8.
  • 9 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
  • 10 Gläsker S. Central nervous system manifestations in VHL: Genetics, pathology and clinical phenotypic features. Fam Cancer 2005;4:37-42.
  • 11 Benzagmout M, Agharbi S, Chakour K, Chaoui ME. Dermoid cyst of the posterior fossa. Neurosciences (Riyadh) 2011;16:153-5.
  • 12 BAUMANN CH, BUCY PC. Paratrigeminal epidermoid tumors. J Neurosurg 1956;13:455-68.
  • 13 Zakrzewski K, Fiks T, Polis L, Liberski PP. Posterior fossa tumours in children and adolescents. A clinicopathological study of 216 cases. Folia Neuropathol 2003;41:251-2.
  • 14 Muzumdar D, Deshpande A, Kumar R, Sharma A, Goel N, Dange N, et al. Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients. J Pediatr Neurosci 2011;6:S78-85.
  • 15 Rutka JT. Medulloblastoma. Clin Neurosurg 1997;44:571-85.
  • 16 Bloom HJ, Bessell EM. Medulloblastoma in adults: A review of 47 patients treated between 1952 and 1981. Int J Radiat Oncol Biol Phys 1990;18:763-72.
  • 17 Chan AW, Tarbell NJ, Black PM, Louis DN, Frosch MP, Ancukiewicz M, et al. Adult medulloblastoma: Prognostic factors and patterns of relapse. Neurosurgery 2000;47:623-31.
  • 18 Djalilian HR, Hall WA. Malignant gliomas of the cerebellum: An analytic review. J Neurooncol 1998;36:247-57.
  • 19 Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, et al. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 2011;20:143-57.
  • 20 Desai KI, Nadkarni TD, Muzumdar DP, Goel A. Prognostic factors for cerebellar astrocytomas in children: A study of 102 cases. Pediatr Neurosurg 2001;35:311-7.
  • 21 Daszkiewicz P, Maryniak A, Roszkowski M, Barszcz S. Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. Childs Nerv Syst 2009;25:855-60.
  • 22 Lesniak MS, Klem JM, Weingart J, Carson BS Sr. Surgical outcome following resection of contrast-enhanced pediatric brainstem gliomas. Pediatr Neurosurg 2003;39:314-22.
  • 23 Donaldson SS, Laningham F, Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol 2006;24:1266-72.
  • 24 Sunderland GJ, Jenkinson MD, Zakaria R. Surgical management of posterior fossa metastases. J Neurooncol 2016;130:535-42.
  • 25 Zhang X, Zhang W, Cao WD, Cheng G, Liu B, Cheng J. A review of current management of brain metastases. Ann Surg Oncol 2012;19:1043-50.
  • 26 Tate M, Sughrue ME, Rutkowski MJ, Kane AJ, Aranda D, McClinton L, et al. The long-term postsurgical prognosis of patients with pineoblastoma. Cancer 2012;118:173-9.
  • 27 Wang YC, Chuang CC, Wei KC, Chang CN, Lee ST, Wu CT, et al. Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas. Sci Rep 2016;6:35743.

Address for correspondence

Dr Abdul Rashid Bhat
C/O: B-4, Faculty Quarters, Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences
Srinagar - 190011, Jammu and Kashmir
India   

Publication History

Received: 29 April 2019

Accepted: 12 March 2020

Article published online:
16 August 2022

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  • References

  • 1 Cushing H. Experience with the cerebellar medulloblastoma: Critical review. Acta Pathol Microbiol Immunol Scand 1930;7:1-86.
  • 2 Samii M, Matthies C. Management of 1000 vestibular schwannomas (acoustic neuromas): Surgical management and results with an emphasis on complications and how to avoid them. Neurosurgery 1997;40:11-21.
  • 3 Seol HJ, Kim CH, Park CK, Kim CH, Kim DG, Chung YS, et al. Optimal extent of resection in vestibular schwannoma surgery: Relationship to recurrence and facial nerve preservation. Neurol Med Chir (Tokyo) 2006;46:176-80.
  • 4 Yamakami I, Uchino Y, Kobayashi E, Yamaura A, Oka N. Removal of large acoustic neurinomas (vestibular schwannomas) by the retrosigmoid approach with no mortality and minimal morbidity. J Neurol Neurosurg Psychiatry 2004;75:453-8.
  • 5 Roberti F, Sekhar LN, Kalavakonda C, Wright DC. Posterior fossa meningiomas: Surgical experience in 161 cases. Surg Neurol 2001;56:8-20.
  • 6 Velho V, Agarwal V, Mally R, Palande DA. Posterior fossa meningioma “our experience” in 64 cases. Asian J Neurosurg 2012;7:116-24.
  • 7 Hakuba A, Nishimura S, Tanaka K, Kishi H, Nakamura T. Clivus meningioma: Six cases of total removal. Neurol Med Chir (Tokyo) 1977;17:63-77.
  • 8 Couldwell WT, Fukushima T, Giannotta SL, Weiss MH. Petroclival meningiomas: Surgical experience in 109 cases. J Neurosurg 1996;84:20-8.
  • 9 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
  • 10 Gläsker S. Central nervous system manifestations in VHL: Genetics, pathology and clinical phenotypic features. Fam Cancer 2005;4:37-42.
  • 11 Benzagmout M, Agharbi S, Chakour K, Chaoui ME. Dermoid cyst of the posterior fossa. Neurosciences (Riyadh) 2011;16:153-5.
  • 12 BAUMANN CH, BUCY PC. Paratrigeminal epidermoid tumors. J Neurosurg 1956;13:455-68.
  • 13 Zakrzewski K, Fiks T, Polis L, Liberski PP. Posterior fossa tumours in children and adolescents. A clinicopathological study of 216 cases. Folia Neuropathol 2003;41:251-2.
  • 14 Muzumdar D, Deshpande A, Kumar R, Sharma A, Goel N, Dange N, et al. Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients. J Pediatr Neurosci 2011;6:S78-85.
  • 15 Rutka JT. Medulloblastoma. Clin Neurosurg 1997;44:571-85.
  • 16 Bloom HJ, Bessell EM. Medulloblastoma in adults: A review of 47 patients treated between 1952 and 1981. Int J Radiat Oncol Biol Phys 1990;18:763-72.
  • 17 Chan AW, Tarbell NJ, Black PM, Louis DN, Frosch MP, Ancukiewicz M, et al. Adult medulloblastoma: Prognostic factors and patterns of relapse. Neurosurgery 2000;47:623-31.
  • 18 Djalilian HR, Hall WA. Malignant gliomas of the cerebellum: An analytic review. J Neurooncol 1998;36:247-57.
  • 19 Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, et al. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 2011;20:143-57.
  • 20 Desai KI, Nadkarni TD, Muzumdar DP, Goel A. Prognostic factors for cerebellar astrocytomas in children: A study of 102 cases. Pediatr Neurosurg 2001;35:311-7.
  • 21 Daszkiewicz P, Maryniak A, Roszkowski M, Barszcz S. Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. Childs Nerv Syst 2009;25:855-60.
  • 22 Lesniak MS, Klem JM, Weingart J, Carson BS Sr. Surgical outcome following resection of contrast-enhanced pediatric brainstem gliomas. Pediatr Neurosurg 2003;39:314-22.
  • 23 Donaldson SS, Laningham F, Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol 2006;24:1266-72.
  • 24 Sunderland GJ, Jenkinson MD, Zakaria R. Surgical management of posterior fossa metastases. J Neurooncol 2016;130:535-42.
  • 25 Zhang X, Zhang W, Cao WD, Cheng G, Liu B, Cheng J. A review of current management of brain metastases. Ann Surg Oncol 2012;19:1043-50.
  • 26 Tate M, Sughrue ME, Rutkowski MJ, Kane AJ, Aranda D, McClinton L, et al. The long-term postsurgical prognosis of patients with pineoblastoma. Cancer 2012;118:173-9.
  • 27 Wang YC, Chuang CC, Wei KC, Chang CN, Lee ST, Wu CT, et al. Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas. Sci Rep 2016;6:35743.

Zoom
Table 1: Histopathology, sex, and postoperative outcome in posterior fossa tumors
Zoom
Figure 1: A patient of left cerebello.pontine angle vestibular schwannoma; Intraoperative photos in sitting position and post-operative axial magnetic resonance imaging with histopathological photograph (H and E; ˣ40)
Zoom
Table 2: Surgical outcome related to histopathological types of tumors in posterior fossa
Zoom
Figure 2: Two (Sibling) patients of hemangioblastomas; shows Imaging, resected specimen and histological photograph (H and E; x400). The large serpentinous vessel supplying the intramural nodule as viewed on magnetic resonance images, in the lower row, is seen on intraoperative photograph
Zoom
Figure 3: Computed tomography scan, magnetic resonance images, intraoperative photographs in sitting position and tumor specimen of a cerebello-pontine angle Epidermoid with histopathological microphotograph
Zoom
Figure 4: An 8 years male child with medulloblastoma shows radio-imaging and intraoperative pictures. Histopathological images show infiltrating tumor cells invading cerebellar cortex (H and E; x20)
Zoom
Figure 5: Adult medulloblastoma; depicts computed tomography and magnetic resonance images, intraoperative photographs in sitting position and postoperative computed tomography scan at day fourth. The histopathological micrograph shows moderate anaplasia (H and E; ˣ100)
Zoom
Figure 6: Magnetic resonance images and intraoperative photographs of an ependymoma of 4th ventricle (WHO Grade II). The aqueduct of sylvius is seen opening inside the fourth ventricle. Low power microphotograph shows the histopathological view of the tumor