CC BY-NC-ND 4.0 · Indian J Plast Surg 2016; 49(03): 302-313
DOI: 10.4103/0970-0358.197238
Prof. Mira Sen (Banerjee) CME Article
Association of Plastic Surgeons of India

Healing ulcers and preventing their recurrences in the diabetic foot

S. Raja Sabapathy
Department of Plastic, Hand and Reconstructive Microsurgery and Burns, Ganga Hospital, Coimbatore, Tamil Nadu, India
,
Madhu Periasamy
Department of Plastic, Hand and Reconstructive Microsurgery and Burns, Ganga Hospital, Coimbatore, Tamil Nadu, India
› Author Affiliations
Further Information

Address for correspondence:

Dr. S. Raja Sabapathy
Department of Plastic, Hand and Reconstructive Microsurgery and Burns
Ganga Hospital, 313, Mettupalayam Road, Coimbatore - 641 043, Tamil Nadu
India   

Publication History

Publication Date:
26 August 2019 (online)

 

ABSTRACT

Fifteen percent of people with diabetes develop an ulcer in the course of their lifetime. Eighty-five percent of the major amputations in diabetes mellitus are preceded by an ulcer. Management of ulcers and preventing their recurrence is important for the quality of life of the individual and reducing the cost of care of treatment. The main causative factors of ulceration are neuropathy, vasculopathy and limited joint mobility. Altered bio-mechanics due to the deformities secondary to neuropathy and limited joint mobility leads to focal points of increased pressure, which compromises circulation leading to ulcers. Ulcer management must not only address the healing of ulcers but also should correct the altered bio-mechanics to reduce the focal pressure points and prevent recurrence. An analysis of 700 patients presenting with foot problems to the Diabetic Clinic of Ganga Hospital led to the stratification of these patients into four classes of incremental severity. Class 1 – the foot at risk, Class 2 – superficial ulcers without infection, Class 3 – the crippled foot and Class 4 – the critical foot. Almost 77.5% presented in either Class 3 or 4 with complicated foot ulcers requiring major reconstruction or amputation. Class 1 foot can be managed conservatively with foot care and appropriate foot wear. Class 2 in addition to measures for ulcer healing would need surgery to correct the altered bio-mechanics to prevent the recurrence. The procedures called surgical offloading would depend on the site of the ulcer and would need an in-depth clinical study of the foot. Class 3 would need major reconstructive procedures and Class 4 would need amputation since it may be life-threatening. As clinicians, our main efforts must be focused towards identifying patients in Class 1 and offer advice on foot care and Class 2 where appropriate surgical offloading procedure would help preserve the foot.


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Conflicts of interest

There are no conflicts of interest.

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  • 1 International Diabetes Federation. IDF Diabetes. 7ed. Brussels, Belgium: International Diabetes Federation; 2015. Available from: http://www.diabetesatlas.org [Last cited on 2016 Apr 14]
  • 2 American Diabetes Association. Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care 1999; 22: 1354-60
  • 3 Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005; 366: 1719-24
  • 4 Trautner C, Haastert B, Giani G, Berger M. Incidence of lower limb amputations and diabetes. Diabetes Care 1996; 19: 1006-9
  • 5 van Schie CH. A review of the biomechanics of the diabetic foot. Int J Low Extrem Wounds 2005; 4: 160-70
  • 6 D’Ambrogi E, Giacomozzi C, Macellari V, Uccioli L. Abnormal foot function in diabetic patients: The altered onset of Windlass mechanism. Diabet Med 2005; 22: 1713-9
  • 7 Viswanathan V, Kumpatla S. Pattern and causes of amputation in diabetic patients – A multicentric study from India. J Assoc Physicians India 2011; 59: 148-51
  • 8 Pendsey SP. Understanding diabetic foot. Int J Diabetes Dev Ctries 2010; 30: 75-9
  • 9 Viswanathan V, Snehalatha C, Sivagami M, Seena R, Ramachandran A. Association of limited joint mobility and high plantar pressure in diabetic foot ulceration in Asian Indians. Diabetes Res Clin Pract 2003; 60: 57-61
  • 10 Fernando DJ, Masson EA, Veves A, Boulton AJ. Relationship of limited joint mobility to abnormal foot pressures and diabetic foot ulceration. Diabetes Care 1991; 14: 8-11
  • 11 Young MJ, Cavanagh PR, Thomas G, Johnson MM, Murray H, Boulton AJ. The effect of callus removal on dynamic plantar foot pressures in diabetic patients. Diabet Med 1992; 9: 55-7
  • 12 Rhim B, Harkless L. Prevention: Can we stop problems before they arise?. Semin Vasc Surg 2012; 25: 122-8
  • 13 Suresh K, Pradhan A. Approach to dysvascular diabetic foot. In: Pendsey S. editor Contemporary Management of the Diabetic Foot. India: JP Medical Limited; 2013: p. 118-33
  • 14 Adam DJ, Beard JD, Cleveland T, Bell J, Bradbury AW, Forbes JF. et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): Multicentre, randomised controlled trial. Lancet 2005; 366: 1925-34
  • 15 Moxey PW, Chong PF. Surgical revascularization of the diabetic foot. In: Shearman CP. editor Management of Diabetic Foot Complications. London: Springer; 2015: p. 113-25
  • 16 Armstrong DG, Lavery LA, Kimbriel HR, Nixon BP, Boulton AJ. Activity patterns of patients with diabetic foot ulceration: Patients with active ulceration may not adhere to a standard pressure off-loading regimen. Diabetes Care 2003; 26: 2595-7
  • 17 Knowles EA, Boulton AJ. Do people with diabetes wear their prescribed footwear?. Diabet Med 1996; 13: 1064-8
  • 18 Ctercteko GC, Dhanendran M, Hutton WC, Le Quesne LP. Vertical forces acting on the feet of diabetic patients with neuropathic ulceration. Br J Surg 1981; 68: 608-14
  • 19 Birke JA, Sims DS. Plantar sensory threshold in the ulcerative foot. Lepr Rev 1986; 57: 261-7
  • 20 Boffeli TJ, Bean JK, Natwick JR. Biomechanical abnormalities and ulcers of the great toe in patients with diabetes. J Foot Ankle Surg 2002; 41: 359-64
  • 21 Durrant B, Chockalingam N. Functional hallux limitus: A review. J Am Podiatr Med Assoc 2009; 99: 236-43
  • 22 Gefen A, Megido-Ravid M, Azariah M, Itzchak Y, Arcan M. Integration of plantar soft tissue stiffness measurements in routine MRI of the diabetic foot. Clin Biomech (Bristol, Avon) 2001; 16: 921-5
  • 23 Gefen A. Plantar soft tissue loading under the medial metatarsals in the standing diabetic foot. Med Eng Phys 2003; 25: 491-9
  • 24 Pai S, Ledoux WR. The compressive mechanical properties of diabetic and non-diabetic plantar soft tissue. J Biomech 2010; 43: 1754-60
  • 25 Kim JY, Hwang S, Lee Y. Selective plantar fascia release for non-healing diabetic plantar ulcerations. J Bone Joint Surg Am 2012; 94: 1297-302
  • 26 Lin SS, Bono CM, Lee TH. Total contact casting and Keller arthoplasty for diabetic great toe ulceration under the interphalangeal joint. Foot Ankle Int 2000; 21: 588-93
  • 27 Armstrong DG, Lavery LA, Vazquez JR, Short B, Kimbriel HR, Nixon BP. et al. Clinical efficacy of the first metatarsophalangeal joint arthroplasty as a curative procedure for hallux interphalangeal joint wounds in patients with diabetes. Diabetes Care 2003; 26: 3284-7
  • 28 Tamir E, Vigler M, Avisar E, Finestone AS. Percutaneous tenotomy for the treatment of diabetic toe ulcers. Foot Ankle Int 2014; 35: 38-43
  • 29 Rajbhandari SM, Sutton M, Davies C, Tesfaye S, Ward JD. ‘Sausage toe’: A reliable sign of underlying osteomyelitis. Diabet Med 2000; 17: 74-7
  • 30 Taylor RG. The treatment of claw toes by multiple transfers of flexor into extensor tendons. J Bone Joint Surg Br 1951; 33-B: 539-42
  • 31 Barbari SG, Brevig K. Correction of clawtoes by the Girdlestone-Taylor flexor-extensor transfer procedure. Foot Ankle 1984; 5: 67-73
  • 32 Albert S, Rinoie C. Effect of custom orthotics on plantar pressure distribution in the pronated diabetic foot. J Foot Ankle Surg 1994; 33: 598-604
  • 33 Birke JA, Franks BD, Foto JG. First ray joint limitation, pressure, and ulceration of the first metatarsal head in diabetes mellitus. Foot Ankle Int 1995; 16: 277-84
  • 34 Caselli A, Pham H, Giurini JM, Armstrong DG, Veves A. The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration. Diabetes Care 2002; 25: 1066-71
  • 35 Bus SA, Maas M, Cavanagh PR, Michels RP, Levi M. Plantar fat-pad displacement in neuropathic diabetic patients with toe deformity: A magnetic resonance imaging study. Diabetes Care 2004; 27: 2376-81
  • 36 Mueller MJ, Sinacore DR, Hastings MK, Strube MJ, Johnson JE. Effect of achilles tendon lengthening on neuropathic plantar ulcers. A randomized clinical trial. J Bone Joint Surg Am 2003; 85-A: 1436-45
  • 37 Laborde JM. Midfoot ulcers treated with gastrocnemius-soleus recession. Foot Ankle Int 2009; 30: 842-6
  • 38 Dayer R, Assal M. Chronic diabetic ulcers under the first metatarsal head treated by staged tendon balancing: A prospective cohort study. J Bone Joint Surg Br 2009; 91: 487-93
  • 39 Griffiths GD, Wieman TJ. Metatarsal head resection for diabetic foot ulcers. Arch Surg 1990; 125: 832-5
  • 40 Patel VG, Wieman TJ. Effect of metatarsal head resection for diabetic foot ulcers on the dynamic plantar pressure distribution. Am J Surg 1994; 167: 297-301
  • 41 Giurini JM, Habershaw GM, Chrzan JS. Panmetatarsal head resection in chronic neuropathic ulceration. J Foot Surg 1987; 26: 249-52
  • 42 Lowery NJ, Woods JB, Armstrong DG, Wukich DK. Surgical management of Charcot neuroarthropathy of the foot and ankle: A systematic review. Foot Ankle Int 2012; 33: 113-21
  • 43 Early JS, Hansen ST. Surgical reconstruction of the diabetic foot: A salvage approach for midfoot collapse. Foot Ankle Int 1996; 17: 325-30
  • 44 Catanzariti AR, Mendicino R, Haverstock B. Ostectomy for diabetic neuroarthropathy involving the midfoot. J Foot Ankle Surg 2000; 39: 291-300
  • 45 Chilvers M, Malicky ES, Anderson JG, Bohay DR, Manoli 2nd A. Heel overload associated with heel cord insufficiency. Foot Ankle Int 2007; 28: 687-9
  • 46 Turco VJ, Spinella AJ. Achilles tendon ruptures – Peroneus brevis transfer. Foot Ankle 1987; 7: 253-9
  • 47 Wapner KL, Pavlock GS, Hecht PJ, Naselli F, Walther R. Repair of chronic achilles tendon rupture with flexor hallucis longus tendon transfer. Foot Ankle 1993; 14: 443-9
  • 48 Wilcox DK, Bohay DR, Anderson JG. Treatment of chronic achilles tendon disorders with flexor hallucis longus tendon transfer/augmentation. Foot Ankle Int 2000; 21: 1004-10
  • 49 Pearce CJ, Sexton S, Gerrard D, Hatrick A, Solan M. Successful treatment of a chronically infected and necrotic tendo achilles in a diabetic with excision, flexor hallucis longus transfer and split-skin grafting. J Bone Joint Surg Br 2008; 90: 186-8
  • 50 Wang CC, Lin LC, Hsu CK, Shen PH, Lien SB, Hwa SY. et al. Anatomic reconstruction of neglected achilles tendon rupture with autogenous peroneal longus tendon by endobutton fixation. J Trauma 2009; 67: 1109-12
  • 51 Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Davignon DR, Smith DG. A prospective study of risk factors for diabetic foot ulcer. The seattle diabetic foot study. Diabetes Care 1999; 22: 1036-42
  • 52 Hong JP. Reconstruction of the diabetic foot using the anterolateral thigh perforator flap. Plast Reconstr Surg 2006; 117: 1599-608
  • 53 Kadam D. Microsurgical reconstruction of plantar ulcers of the insensate foot. J Reconstr Microsurg 2016; 32: 402-10
  • 54 Attinger CE, Ducic I, Cooper P, Zelen CM. The role of intrinsic muscle flaps of the foot for bone coverage in foot and ankle defects in diabetic and nondiabetic patients. Plast Reconstr Surg 2002; 110: 1047-54

Address for correspondence:

Dr. S. Raja Sabapathy
Department of Plastic, Hand and Reconstructive Microsurgery and Burns
Ganga Hospital, 313, Mettupalayam Road, Coimbatore - 641 043, Tamil Nadu
India   

  • REFERENCES

  • 1 International Diabetes Federation. IDF Diabetes. 7ed. Brussels, Belgium: International Diabetes Federation; 2015. Available from: http://www.diabetesatlas.org [Last cited on 2016 Apr 14]
  • 2 American Diabetes Association. Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care 1999; 22: 1354-60
  • 3 Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005; 366: 1719-24
  • 4 Trautner C, Haastert B, Giani G, Berger M. Incidence of lower limb amputations and diabetes. Diabetes Care 1996; 19: 1006-9
  • 5 van Schie CH. A review of the biomechanics of the diabetic foot. Int J Low Extrem Wounds 2005; 4: 160-70
  • 6 D’Ambrogi E, Giacomozzi C, Macellari V, Uccioli L. Abnormal foot function in diabetic patients: The altered onset of Windlass mechanism. Diabet Med 2005; 22: 1713-9
  • 7 Viswanathan V, Kumpatla S. Pattern and causes of amputation in diabetic patients – A multicentric study from India. J Assoc Physicians India 2011; 59: 148-51
  • 8 Pendsey SP. Understanding diabetic foot. Int J Diabetes Dev Ctries 2010; 30: 75-9
  • 9 Viswanathan V, Snehalatha C, Sivagami M, Seena R, Ramachandran A. Association of limited joint mobility and high plantar pressure in diabetic foot ulceration in Asian Indians. Diabetes Res Clin Pract 2003; 60: 57-61
  • 10 Fernando DJ, Masson EA, Veves A, Boulton AJ. Relationship of limited joint mobility to abnormal foot pressures and diabetic foot ulceration. Diabetes Care 1991; 14: 8-11
  • 11 Young MJ, Cavanagh PR, Thomas G, Johnson MM, Murray H, Boulton AJ. The effect of callus removal on dynamic plantar foot pressures in diabetic patients. Diabet Med 1992; 9: 55-7
  • 12 Rhim B, Harkless L. Prevention: Can we stop problems before they arise?. Semin Vasc Surg 2012; 25: 122-8
  • 13 Suresh K, Pradhan A. Approach to dysvascular diabetic foot. In: Pendsey S. editor Contemporary Management of the Diabetic Foot. India: JP Medical Limited; 2013: p. 118-33
  • 14 Adam DJ, Beard JD, Cleveland T, Bell J, Bradbury AW, Forbes JF. et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): Multicentre, randomised controlled trial. Lancet 2005; 366: 1925-34
  • 15 Moxey PW, Chong PF. Surgical revascularization of the diabetic foot. In: Shearman CP. editor Management of Diabetic Foot Complications. London: Springer; 2015: p. 113-25
  • 16 Armstrong DG, Lavery LA, Kimbriel HR, Nixon BP, Boulton AJ. Activity patterns of patients with diabetic foot ulceration: Patients with active ulceration may not adhere to a standard pressure off-loading regimen. Diabetes Care 2003; 26: 2595-7
  • 17 Knowles EA, Boulton AJ. Do people with diabetes wear their prescribed footwear?. Diabet Med 1996; 13: 1064-8
  • 18 Ctercteko GC, Dhanendran M, Hutton WC, Le Quesne LP. Vertical forces acting on the feet of diabetic patients with neuropathic ulceration. Br J Surg 1981; 68: 608-14
  • 19 Birke JA, Sims DS. Plantar sensory threshold in the ulcerative foot. Lepr Rev 1986; 57: 261-7
  • 20 Boffeli TJ, Bean JK, Natwick JR. Biomechanical abnormalities and ulcers of the great toe in patients with diabetes. J Foot Ankle Surg 2002; 41: 359-64
  • 21 Durrant B, Chockalingam N. Functional hallux limitus: A review. J Am Podiatr Med Assoc 2009; 99: 236-43
  • 22 Gefen A, Megido-Ravid M, Azariah M, Itzchak Y, Arcan M. Integration of plantar soft tissue stiffness measurements in routine MRI of the diabetic foot. Clin Biomech (Bristol, Avon) 2001; 16: 921-5
  • 23 Gefen A. Plantar soft tissue loading under the medial metatarsals in the standing diabetic foot. Med Eng Phys 2003; 25: 491-9
  • 24 Pai S, Ledoux WR. The compressive mechanical properties of diabetic and non-diabetic plantar soft tissue. J Biomech 2010; 43: 1754-60
  • 25 Kim JY, Hwang S, Lee Y. Selective plantar fascia release for non-healing diabetic plantar ulcerations. J Bone Joint Surg Am 2012; 94: 1297-302
  • 26 Lin SS, Bono CM, Lee TH. Total contact casting and Keller arthoplasty for diabetic great toe ulceration under the interphalangeal joint. Foot Ankle Int 2000; 21: 588-93
  • 27 Armstrong DG, Lavery LA, Vazquez JR, Short B, Kimbriel HR, Nixon BP. et al. Clinical efficacy of the first metatarsophalangeal joint arthroplasty as a curative procedure for hallux interphalangeal joint wounds in patients with diabetes. Diabetes Care 2003; 26: 3284-7
  • 28 Tamir E, Vigler M, Avisar E, Finestone AS. Percutaneous tenotomy for the treatment of diabetic toe ulcers. Foot Ankle Int 2014; 35: 38-43
  • 29 Rajbhandari SM, Sutton M, Davies C, Tesfaye S, Ward JD. ‘Sausage toe’: A reliable sign of underlying osteomyelitis. Diabet Med 2000; 17: 74-7
  • 30 Taylor RG. The treatment of claw toes by multiple transfers of flexor into extensor tendons. J Bone Joint Surg Br 1951; 33-B: 539-42
  • 31 Barbari SG, Brevig K. Correction of clawtoes by the Girdlestone-Taylor flexor-extensor transfer procedure. Foot Ankle 1984; 5: 67-73
  • 32 Albert S, Rinoie C. Effect of custom orthotics on plantar pressure distribution in the pronated diabetic foot. J Foot Ankle Surg 1994; 33: 598-604
  • 33 Birke JA, Franks BD, Foto JG. First ray joint limitation, pressure, and ulceration of the first metatarsal head in diabetes mellitus. Foot Ankle Int 1995; 16: 277-84
  • 34 Caselli A, Pham H, Giurini JM, Armstrong DG, Veves A. The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration. Diabetes Care 2002; 25: 1066-71
  • 35 Bus SA, Maas M, Cavanagh PR, Michels RP, Levi M. Plantar fat-pad displacement in neuropathic diabetic patients with toe deformity: A magnetic resonance imaging study. Diabetes Care 2004; 27: 2376-81
  • 36 Mueller MJ, Sinacore DR, Hastings MK, Strube MJ, Johnson JE. Effect of achilles tendon lengthening on neuropathic plantar ulcers. A randomized clinical trial. J Bone Joint Surg Am 2003; 85-A: 1436-45
  • 37 Laborde JM. Midfoot ulcers treated with gastrocnemius-soleus recession. Foot Ankle Int 2009; 30: 842-6
  • 38 Dayer R, Assal M. Chronic diabetic ulcers under the first metatarsal head treated by staged tendon balancing: A prospective cohort study. J Bone Joint Surg Br 2009; 91: 487-93
  • 39 Griffiths GD, Wieman TJ. Metatarsal head resection for diabetic foot ulcers. Arch Surg 1990; 125: 832-5
  • 40 Patel VG, Wieman TJ. Effect of metatarsal head resection for diabetic foot ulcers on the dynamic plantar pressure distribution. Am J Surg 1994; 167: 297-301
  • 41 Giurini JM, Habershaw GM, Chrzan JS. Panmetatarsal head resection in chronic neuropathic ulceration. J Foot Surg 1987; 26: 249-52
  • 42 Lowery NJ, Woods JB, Armstrong DG, Wukich DK. Surgical management of Charcot neuroarthropathy of the foot and ankle: A systematic review. Foot Ankle Int 2012; 33: 113-21
  • 43 Early JS, Hansen ST. Surgical reconstruction of the diabetic foot: A salvage approach for midfoot collapse. Foot Ankle Int 1996; 17: 325-30
  • 44 Catanzariti AR, Mendicino R, Haverstock B. Ostectomy for diabetic neuroarthropathy involving the midfoot. J Foot Ankle Surg 2000; 39: 291-300
  • 45 Chilvers M, Malicky ES, Anderson JG, Bohay DR, Manoli 2nd A. Heel overload associated with heel cord insufficiency. Foot Ankle Int 2007; 28: 687-9
  • 46 Turco VJ, Spinella AJ. Achilles tendon ruptures – Peroneus brevis transfer. Foot Ankle 1987; 7: 253-9
  • 47 Wapner KL, Pavlock GS, Hecht PJ, Naselli F, Walther R. Repair of chronic achilles tendon rupture with flexor hallucis longus tendon transfer. Foot Ankle 1993; 14: 443-9
  • 48 Wilcox DK, Bohay DR, Anderson JG. Treatment of chronic achilles tendon disorders with flexor hallucis longus tendon transfer/augmentation. Foot Ankle Int 2000; 21: 1004-10
  • 49 Pearce CJ, Sexton S, Gerrard D, Hatrick A, Solan M. Successful treatment of a chronically infected and necrotic tendo achilles in a diabetic with excision, flexor hallucis longus transfer and split-skin grafting. J Bone Joint Surg Br 2008; 90: 186-8
  • 50 Wang CC, Lin LC, Hsu CK, Shen PH, Lien SB, Hwa SY. et al. Anatomic reconstruction of neglected achilles tendon rupture with autogenous peroneal longus tendon by endobutton fixation. J Trauma 2009; 67: 1109-12
  • 51 Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Davignon DR, Smith DG. A prospective study of risk factors for diabetic foot ulcer. The seattle diabetic foot study. Diabetes Care 1999; 22: 1036-42
  • 52 Hong JP. Reconstruction of the diabetic foot using the anterolateral thigh perforator flap. Plast Reconstr Surg 2006; 117: 1599-608
  • 53 Kadam D. Microsurgical reconstruction of plantar ulcers of the insensate foot. J Reconstr Microsurg 2016; 32: 402-10
  • 54 Attinger CE, Ducic I, Cooper P, Zelen CM. The role of intrinsic muscle flaps of the foot for bone coverage in foot and ankle defects in diabetic and nondiabetic patients. Plast Reconstr Surg 2002; 110: 1047-54