Keywords:
Pseudotumor Cerebri - Acetazolamide - Optic Nerve - Cerebrospinal Fluid - Bariatric
Surgery.
Palavras-chave:
Pseudotumor Cerebral - Acetazolamida - Nervo Óptico - Líquido Cefalorraquidiano -
Cirurgia Bariátrica.
INTRODUCTION
Idiopathic intracranial hypertension (IIH) is a secondary headache caused by an elevation
of the intracranial pressure (ICP). IIH typically affects obese women of childbearing
age[1]. In a recent study in the UK, the estimated annual incidence was 4.7, which represents
a growth of 108% in 14 years, and parallels the growth of obesity prevalence[2]. Healthcare resource utilization has also grown as reflected by a rise of 442% in
hospital admissions in 12 years[2].
CLINICAL PRESENTATION AND DIAGNOSIS
CLINICAL PRESENTATION AND DIAGNOSIS
Headache is the most common symptom, frequently accompanied by transient visual obscurations,
pulsatile tinnitus, back pain, dizziness, neck pain, visual loss, cognitive disturbances,
radicular pain, and horizontal diplopia[3]. Papilledema is found in the vast majority of patients with confirmed IIH[4], and the grade of papilledema is directly related to the risk of permanent visual
loss and treatment failure[5]. At diagnosis, visual impairment is present in over 80% of patients, and some degree
of permanent visual loss is observed in 10% of patients[6]. Another less common IIH symptom is diplopia, which is due to sixth nerve palsy,
usually related to a more severe presentation.
The current diagnostic criteria for IIH requires the presence of papilledema, neuroimaging
without evidence of a secondary cause of intracranial hypertension, normal CSF composition,
and elevated lumbar pressure[1]. The detailed diagnosis criteria is found in [Table 1]. IIH rarely presents without papilledema. In these cases, the alternative criteria
require the presence of 3 of the 4 typical indirect findings of intracranial hypertension:
empty sella, flattering of the posterior aspect of the globe, distention of the perioptic
subarachnoid space with or without a tortuous optic nerve, and transverse venous sinus
stenosis in the neuroimaging.
Box 1
Modified diagnostic criteria for idiopathic intracranial hypertension.
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A. Papilledema
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B. Normal neurologic examination except for cranial nerve abnormalities
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|
C. Neuroimaging: Normal brain parenchyma without evidence of hydrocephalus, mass,
or structural lesion and no abnormal meningeal enhancement on MRI, with and without
gadolinium, for typical patients (female and obese), and MRI, with and without gadolinium,
and magnetic resonance venography for others; if MRI is unavailable or contraindicated,
contrast-enhanced CT may be used
|
|
D. Normal CSF composition
|
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E. Elevated lumbar puncture opening pressure (≥250 cmH2O CSF in adults and ≥280 cm
H20 CSF in children) in a properly performed lumbar puncture
|
PATHOPHYSIOLOGY
The pathogenesis of IIH is not yet clear. Dysfunction in the balance between CSF secretion
and drainage seems to be the underlying cause. The high prevalence of obesity among
IIH patients points to the role of metabolic changes, but this association is complex
as obesity is a common condition and IIH is a rare disease. Furthermore, weight loss
leads to clinical improvement[7], and weight gain is linked to IIH recurrence[8]. Recent evidence supports the role of adipokine, leptin, Glucagon-like peptide-1,
and 11ß-hydroxysteroid dehydrogenase (11-ßHSD1) in the pathophysiology of IIH, highlighting
the metabolic nature of this condition[9]. Understanding of the metabolic pathways involved in ICP regulation has led to the
development of novel targeted therapies such as bariatric surgery[10], 11-ßHSD1 inhibitor[11] and GLP-1 receptor agonist.
In IIH patients, the elevated cranial pressure induces microstructural compression
of the optic nerve, impairing axoplasmic flow and causing papilledema and visual loss[12]. The main goal of therapies directly targeting ICP control is to reduce transient
and permanent visual loss.
Headache is the most common symptom and the cause of significant quality of life impairment
for IIH patients[13]. The most common phenotype is a migraine-like headache[14]. Although headache seems to be related to the raised ICP, a substantial number of
patients present with a persistent headache after ICP normalization[15]. Despite the high frequency and burden of headache for IIH patients, to date little
is known about the pathophysiology, and no directed trials have investigated headache
treatment.
TREATMENT
IIH treatment has three main objectives: body weight loss, vision protection, and
headache control.
To date, weight loss is the only modifying disease measure. All patients with BMI
≥ 30 kg/ m² should be oriented for weight control. A multidisciplinary team (nutritionist,
endocrinologist) is sometimes necessary to help patients in weight management. The
precise amount of weight reduction that should be aimed for IIH remission is not established.
However, 5-15% weight gain is a risk factor for developing IIH, so it is reasonable
to advise patients to lose at least 15% weight[16].
PHARMACOLOGICAL TREATMENT
PHARMACOLOGICAL TREATMENT
The main goal of the pharmacological treatment of IIH is to protect from visual loss.
Acetazolamide is the first-choice drug, and its use in patients with mild visual loss
can result in improvement in visual field function and quality of life[17]. The starting dose is 250-500mg twice a day, and it can be titrated until a maximal
dose of 4g daily. Common adverse effects are diarrhea, dysgeusia, fatigue, nausea,
paresthesia, tinnitus, vomiting, depression, and rarely renal stones. Periodic monitoring
of serum electrolytes and venous gasometry should be performed[18].
An open-label study suggested similar efficacy of acetazolamide and topiramate (50-200mg
daily)[19]. Topiramate might be very helpful considering the frequency of obesity and migraine
among IIH patients. Furosemide (maximal dose of 40mg twice a day) is a third option
if the previous drugs cannot be tolerated[20].
SURGICAL PROCEDURES
In the presence of imminent visual deterioration, surgical management is an effective
alternative for visual protection. CSF diversion and optic nerve sheath fenestration
(ONSF) have been employed in the short term.
CSF DIVERSION SURGERY
In many centers, the neurosurgical CSF diversion is a surgical first-line choice.
Ventriculoperitoneal shunt (VPS) and lumboperitoneal shunt (LPS) are both effective
in patients with progressive vision loss based on case series[18]. The shunt procedure did not reverse established visual loss but was effective in
stabilizing the worsening. In 53 patients’ retrospective case series, patients who
underwent a CSF shunt presented papilledema reduction and improvement in visual acuity
and tinnitus. Fundus examination showed a significant reduction in the number of patients
with papilledema from 92% at baseline to 65% at 6 months, 48% at 12 months, and 44%
at 24 months after shunt surgery. The LPS was the most performed procedure in the
studies, but with a high rate of shunt revision when compared to VPS, hence the last
one is most recommended. Ideally, the surgical approach should be performed by an
experienced neurosurgeon with an interest in CSF disorders[21].
In the case series, headache recurrence was documented in about 60-70% of patients
by 1-year post-procedure. Therefore, shunts should not be indicated for the treatment
of IIH-associated headaches in the absence of visual loss[22]. More than half of patients undergoing shunts will require surgical revision and
about one-third underwent multiple revisions. Other complications are reported, such
as abdominal pain, valve and/or circuit obstruction, infection, headaches due to low
CSF pressure, subdural hematoma, and tonsillar herniation. Adjustable valves should
be preferred because of the risk of low-pressure headaches. Deaths are reported in
shunt placement; however, no data were obtained from IIH studies[23]. Despite the adverse events, CSF derivations are still the most available procedure
in fulminant IIH or medication failure, with positive visual outcomes.
OPTIC NERVE SHEATH FENESTRATION
OPTIC NERVE SHEATH FENESTRATION
The optic nerve sheath fenestration (ONSF) is a technique with a lower complication
rate and no reported mortality. Therefore, ONSF is preferred by many experts when
considering the re-approaches after the shunt placement[24]. The ONSF may be performed by neuro-ophthalmologists experienced with the technique,
which limits access in many centers. Reports and case series have shown positive outcomes
with this approach in improving visual acuity and visual field in patients with medication
failure. In the majority of reported cases, ONSF was bilateral, but unilateral ONSF
can be an option especially when there is asymmetric visual impairment, and may improve
not only the operated eye, but also the non-operated eye. In the unilateral technique,
the eye chosen for the fenestration is the one with the worst visual performance.
The possibility to perform a unilateral ONSF with bilateral results reduces the time
of anesthesia and possibility of complications[25].
The rate of OSNF’s complications is low and the main adverse effects are transient,
not needing further surgery procedures: double vision, anisocoria, and ocular hemorrhages.
Permanent complications such as central retinal artery occlusion are reported in <
1% of the cases[26]. OSNF is also considered by some experts as a first-line approach to fulminant visual
loss to protect vision while effective weight loss treatment is achieved. In case
of failure, the patient should undergo a more invasive procedure such as CSF shunt,
avoiding the need for multiple procedures. The results of fenestration in improving
headaches are conflicting, with a single review with about 50% improvement and other
studies with 20-30%. The pathophysiology of headache improvement is uncertain and
may result from a placebo effect[24]. The OSNF is a safe, less invasive, and effective alternative for progressive visual
loss in patients with medication failure in asymmetric papilledema causing unilateral
visual loss[18].
VENOUS SINUS STENTING
A more recent therapeutic approach for IIH is venous sinus stenting, reported for
the first time in 2002[27]. Since then, an increasing number of case series have shown promising results. In
a large meta-analysis with 474 patients, the overall rate of improvement in papilledema,
headache and pulsatile tinnitus was 93.7% (95% CI 90.5% to 96.9%), 79.6% (95% CI 73.3%
to 85.9%) and 90.3% (95% CI 83.8% to 96.70%), respectively (28). It may be reasonable
for highly selected IIH patients with venous sinus stenosis and elevated pressure
gradient across the stenosis region (8mm Hg or higher) in whom standard therapies
failed[18]. Regarding the procedure, venography and manometry should ideally be performed with
the patient awake, along with dual or single antiplatelet drugs administered before
as well as at least 3-6 months following stenting[29].
Recurrence of IIH symptoms after stenting occurred in 9.8% (95% CI 6.7% to 13%) of
patients[28]. High BMI, African-American race, female gender, pure extrinsic compression of the
transverse-sigmoid junction, highly raised opening pressures and persisting papilledema
post-procedure possibly increase the risk of stent failure[30]. On the other hand, patients who had higher mean pressure gradients and higher changes
in pressure gradients after stent placement seem to have favorable outcomes[31].
The rate of major complications (subdural hematoma, subarachnoid hemorrhage, thrombosis,
fistulae) was 1.9% (95% CI 0.07% to 3.1%) and the overall mortality was 0%[28]. Short-lived ipsilateral, stent-adjacent headache was the most common complication
(30%)[32]. The outcomes and the eligibility for the procedure were not standardized among
studies, and randomized clinical trials are lacking.
BARIATRIC SURGERY
As obesity is the main modifiable risk factor for IIH[8] researchers have hypothesized that treatment targeting body weight control improves
clinical outcome (10,14). One randomized controlled trial compared bariatric surgery
(BS) (N= 33) to community weight management (CWM) (N= 33). The primary outcome evaluated
was change in ICP after 12 months. Secondary outcomes included change in ICP after
24 months, visual acuity, Headache Impact Test score (HIT-6), perimetric mean deviation,
and quality of life (measured by the 36-item Short Form Health Survey). At baseline,
the mean BMI was 43.7 in the CWM group and 44.2 in the BS group. In the surgery arm,
different procedures were accepted, and the main method was Roux-en-Y gastric bypass
(44%), followed by gastric banding (37%) and laparoscopic sleeve gastrectomy (18.5%).
At 12 months the mean ICP decreased from 34.8 to 26.4 cm CSF (-8.7 cm CSF; P <0.001)
in the BS arm and from 34.6 cm CSF to 32.0 cm CSF (P =0.08). After 24 months the change
in ICP demonstrated increasing effect size with a difference between the 2 arms of
-8.2 cm CSF (P<0.001). Weight control was more effective in the BS arm compared to
the CWM, with a difference of mean weight loss and excess weight loss of -18.3% (P<
0.001), and -46.4% (P<0.001), respectively. No difference was found between arms regarding
perimetric mean deviation, HIT-6, or quality of life. The authors suggest that the
negative secondary outcomes might have been influenced by the low number of patients
recruited, which was expected considering the complex nature of the surgical intervention.
Although more data is warranted to confirm the clinical benefits of BS for IIH treatment,
this trial supports it as an effective treatment for patients with IIH and a BMI of
35 or higher.
HEADACHE MANAGEMENT
Headache is the most common symptom and near-universal sequela of IIH. Despite the
high morbidity, there is a lack of evidence to guide persistent headache management[14]. The treatments used for visual protection, either clinical with acetazolamide or
surgical, have not shown benefit in improving headaches and therefore should not be
prescribed for this purpose[18].
Management is mostly based on off-label treatments according to headache phenotype.
IIH-related headaches can change phenotype throughout the disease, and a comprehensive
clinical characterization is extremely important for phenotypic definition. A mixture
of diverse phenotypes such as migraine, analgesic overuse headache, tension-type headache,
and even CSF hypotension headache secondary to drainage procedures is not uncommon[33].
In almost 68% of IIH patients, the predominant phenotype is migraine, and therefore,
prophylactic migraine therapy is commonly the treatment of choice. Attention should
be given to avoid prophylactics that increase weight and worsen psychiatric comorbidities
such as depression. Topiramate is the preferred oral prophylactic among neurologists.
It reduces appetite, causes weight loss, and there is evidence that it promotes some
degree of reduction in ICP. A limiting factor for topiramate is tolerability of the
most reported adverse effects, like paresthesia and cognitive complaints. There are
no randomized trials comparing the antimigraine therapeutics in IIH[33].
Recently, a prospective open-label study evaluated patients with persistent headaches
using Erenumab, a calcitonin gene-related peptide (CGRP) receptor monoclonal antibody.
Erenumab significantly reduced (by 71%) days with moderate to severe headache and
days with any headache (by 45%) from baseline to 12 months. In addition to improvement
in pain, there was also a significant improvement in presenteeism, absenteeism, and
analgesic use days. Erenumab had high tolerability without any patient leaving the
study due to side effects. CGRP has been studied and implicated in the pathophysiology
of migraine and may play a role in the pathophysiology of IIH-related headaches. Therefore,
Anti-CGRP antibodies may be a potential therapeutic approach for IIH persistent headache[34].
