Correlation of clinical, diagnostic and histopathological parameters in dogs with chronic lymphocytic-plasmacytic enteropathy

Katharina Moser; Stefanie Mitze; Erik Teske; Wolf von Bomhard; Christian Stockhaus

doi:10.15654/TPK-170445

Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Table of Contents

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46(01): 15-20
DOI: 10.15654/TPK-170445

Original Article

Schattauer GmbH

Correlation of clinical, diagnostic and histopathological parameters in dogs with chronic lymphocytic-plasmacytic enteropathy

Korrelation von klinischen, diagnostischen und histopathologischen Parametern bei Hunden mit chronischen Enteropathien

Authors

Katharina Moser

¹Small Animal Clinic Haar, Haar, Germany
Stefanie Mitze

¹Small Animal Clinic Haar, Haar, Germany
Erik Teske

²Department of Clinical Science of Companion Animals, University of Utrecht, The Netherlands
Wolf von Bomhard

³Speciality Practice for Veterinary Pathology, Munich, Germany
Christian Stockhaus

¹Small Animal Clinic Haar, Haar, Germany

Abstract

Summary

Objective: The objective of this study was to correlate clinical signs and diagnostic parameters with duodenal inflammatory and architectural changes in dogs with lymphocytic-plasmacytic enteropathy. Material and methods: In a retrospective study dogs presented between 2003 and 2014 with chronic gastrointestinal signs (duration > 3 weeks) and histologic evidence of intestinal lymphocytic-plasmacytic inflammation were evaluated. Clinical signs, serum albumin, cobalamin and folic acid concentrations were recorded and a sonographic, endoscopic, histologic and cytological inflammatory score was determined. Furthermore, the presence of lacteal dilation, villus stunting, crypt lesions, epithelial integrity and increased intraepithelial lympho cytes was evaluated. Results: A total of 270 dogs were retrospectively evaluated. No significant correlation was found between clinical signs and sonographic, endoscopic or duodenal inflammatory score. Dogs with histological signs of lacteal dilation (p = 0.001) and increased intraepithelial lymphocytes (p = 0.005) had significantly higher clinical scores compared to dogs without these changes. No correlation was found between clinical score and villous stunting or crypt lesions. Hypoalbuminemia and hypocobalaminemia correlated significantly with lacteal dilation (p = 0.001, p = 0.009) and increased intraepithelial lymphocytes (p = 0.036, p = 0.018). Clinical significance: Some clinical and diagnostic parameter correlate with histopathologic features whereas others do not. Morphological features seem to be more important than the intensity of the duodenal inflammation in the assessment of the disease.

Zusammenfassung

Ziel dieser Studie war, bei Hunden mit lymphoplasmazellulären Enteropathien klinische und diagnostische Parameter mit histopathologischen Veränderungen im Duodenum zu vergleichen. Material und Methoden: Die retrospektive Studie umfasste die Daten von Hunden, die zwischen 2003 und 2014 mit chronischen (> 3 Wochen) gastrointestinalen Symptomen vorgestellt wurden und bei denen eine histologisch bestätigte lymphoplasmazelluläre Duodenitis vorlag. Erfasst wurden die klinischen Symptome und die Serumkonzentrationen von Albumin, Cobalamin und Folsäure. Ferner erfolgte die Zuteilung eines sonographischen, endoskopischen, histologischen und zytologischen Entzündungsscores. Die histologischen Befunde wurden auf Zottenatrophie, Kryptenläsionen, epitheliale Integrität, Lymphangiektasie sowie erhöhte Zahl intraepithelialer Lymphozyten untersucht. Ergebnisse: Insgesamt 270 Hunde erfüllten die Einschlusskriterien. Zwischen klinischen Symptomen und dem sonographischen, endoskopischen, histologischen oder zytologischen Score ergab sich keine signifikante Korrelation. Hunde mit Lymphangiektasien (p = 0,001) oder erhöhter Anzahl an intraepithelialen Lymphozyten (p = 0,005) hatten signifikant höhere klinische Scores als Hunde ohne diese histopathologischen Veränderungen. Eine Korrelation zwischen klinischem Score und Zottenatrophie oder Kryptenläsionen war nicht nachweisbar. Hypoalbuminämie und Hypocobalaminämie korrelierten signifikant mit Lymphangiektasie (p = 0,001, p = 0,009) und erhöhter Anzahl intraepithelialer Lymphozyten (p = 0,036, p = 0,018). Schlussfolgerung: Einzelne klinische und diagnostische Parameter korrelieren mit den histopathologischen Veränderungen des Duodenums. Die morphologischen Veränderungen scheinen in der Beurteilung der Entero pathie eine wichtigere Rolle zu spielen als der Grad der Entzündung.

Keywords

Chronic enteropathy - lymphocytic-plasmacytic inflammation - histopathology - endoscopy

Schlüssel-Wörter

Chronische Enteropathie - lymphoplasmazelluläre Entzündung - Histopathologie - Endoskopie

Full Text

References

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