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Thromb Haemost 2016; 115(03): 520-532
DOI: 10.1160/th15-08-0620
Review Article
Schattauer GmbH

The impact of statin therapy on plasma levels of von Willebrand factor antigen

Systematic review and meta-analysis of randomised placebo-controlled trials
Amirhossein Sahebkar
1   Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2   Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
,
Corina Serban
3   Department of Functional Sciences, Discipline of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
,
Sorin Ursoniu
4   Department of Functional Sciences, Discipline of Public Health, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
,
Dimitri P. Mikhailidis
5   Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK
,
Anetta Undas
6   Institute of Cardiology, Jagiellonian University Medical College, and John Paul II Hospital, Krakow, Poland
,
Gregory Y. H. Lip
7   University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
,
Vera Bittner
8   Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
,
Kausik K. Ray
9   Department of Primary Care and Public Health, School of Public Health, Imperial College London, UK
,
Gerald F. Watts
10   Lipid Disorders Clinic, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, West Australia, Australia
,
G. Kees Hovingh
11   Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
,
Jacek Rysz
12   Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland
,
John J. P. Kastelein
11   Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
,
Maciej Banach
12   Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland
,
Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group › Author Affiliations
Further Information

Publication History

Received: 03 August 2015

Accepted after minor revision: 27 October 2015

Publication Date:
20 March 2018 (online)

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Summary

Increased plasma levels of von Willebrand factor antigen (vWF:Ag) are associated with high risk of coronary artery disease. The effect of statin therapy on vWF:Ag levels remains uncertain. Therefore the aim of this meta-analysis was to evaluate the effect of statin therapy on vWF:Ag Levels. A systematic multiple-database search was carried out to identify randomized controlled trials (RCTs) that investigated the effect of statins on plasma vWF:Ag levels. Random-effect meta-analysis of 21 treatment arms revealed a significant decrease in plasma vWF:Ag levels following statin therapy (SMD: −0.54, 95 %CI: −0.87, −0.21, p=0.001). In subgroup analyses, the greatest effect was observed with simvastatin (SMD: −1.54, 95 %CI: −2.92, −0.17, p=0.028) and pravastatin (SMD: −0.61, 95 %CI: −1.18, −0.04, p=0.035), but not with fluvastatin (SMD: −0.34, 95 %CI: −0.69, 0.02, p=0.065), atorvastatin (SMD: −0.23, 95 %CI: −0.57, 0.11, p=0.179) and rosuvastatin (SMD: −0.20, 95 %CI: −0.71, 0.30, p=0.431). The lowering effect of statins on plasma vWF:Ag levels was greater in the subset of studies lasting ≥ 12 weeks (SMD: −0.70, 95 %CI: −1.19, −0.22, p=0.005) compared with that of studies lasting > 12 weeks (SMD: −0.34, 95 %CI: −0.67, 0.003, p=0.052). Finally, low-intensity statin therapy was not associated with a significant reduction in vWF:Ag levels (SMD: −0.28, 95 %CI: −0.82, 0.27, p=0.320), but a significant effect was observed in high-intensity statin trials (SMD: −0.66, 95 %CI: −1.07, −0.24, p=0.002). This meta-analysis of available RCTs demonstrates a significant reduction in plasma vWF:Ag levels following statin therapy.

Note: The review process for this manuscript was fully handled by Christian Weber, Editor in Chief.

Keywords

von Willebrand Antigen - statins - cardiovascular diseases - atherosclerosis - thrombosis
 

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