Diverse packaging of TF into platelets

Insights on Brambilla et al. Thromb Haemost 2015; 114: 579-592.

• References

• 1 Muller I, Klocke A, Alex M. et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J 2003; 17: 476-478.
• 2 Schwertz H, Tolley ND, Foulks JM. et al. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 2006; 203: 2433-2440.
• 3 Panes O, Matus V, Saez CG. et al. Human platelets synthesize and express functional tissue factor. Blood 2007; 109: 5242-5250.
• 4 Brambilla M, Facchinetti L, Canzano P. et al. Human megakaryocytes confer Tissue Factor to a subset of shedded platelets to stimulate thrombin generation. Thromb Haemost 2015; 114: 579-592.