Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2015; 114(02): 434-437
DOI: 10.1160/TH14-12-1060

Letters to the Editor

Schattauer GmbH

GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutro-phil aggregates

Jan M. Herter^*

¹Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA

,

Florian Kraft^*

²Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany

³Max Planck Institute for Molecular Biomedicine, Münster, Germany

,

Hugo Van Aken

²Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany

,

Melanie Meersch

²Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany

,

Alexander Zarbock

²Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany

³Max Planck Institute for Molecular Biomedicine, Münster, Germany

,

Jan Rossaint

²Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Germany

³Max Planck Institute for Molecular Biomedicine, Münster, Germany

› Institutsangaben

References
1 Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest 2012; 122: 2731-2740.
2 Herter JM, Rossaint J, Zarbock A. Platelets in inflammation and immunity. J Thromb Haemost 2014; 12: 1764-1775.
3 Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 1998; 94: 657-666.
4 Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor?. Blood 2003; 102: 449-461.
5 Yang J, Furie BC, Furie B. The biology of P-selectin glycoprotein ligand-1: its role as a selectin counter-receptor in leukocyte-endothelial and leukocyte-platelet interaction. Thromb Haemost 1999; 81: 1-7.
6 Evangelista V, Manarini S, Sideri R. et al. Platelet/ polymorphonuclear leukocyte interaction: P-selectin triggers protein-tyrosine phosphorylation-dependent CD11b/CD18 adhesion: role of PSGL-1 as a signaling molecule. Blood 1999; 93: 876-885.
7 Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115: 3363-3369.
8 Ehlers R, Ustinov V, Chen Z. et al. Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med 2003; 198: 1077-1088.
9 Zarbock A, Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 2006; 116: 3211-3219.
10 Looney MR, Nguyen JX, Hu Y. et al. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 2009; 119: 3450-3461.
11 Kempf T, Zarbock A, Widera C. et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 2011; 17: 581-588.
12 Rossaint J, Vestweber D, Zarbock A. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost 2012; 11: 335-344.
13 Rossaint J, Herter JM, Van Aken H. et al. Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood 2014; 123: 2573-2584.
14 Hsiao EC, Koniaris LG, Zimmers-Koniaris T. et al. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol 2000; 20: 3742-3751.
15 Kempf T, Eden M, Strelau J. et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res 2006; 98: 351-360.
16 Mueller H, Stadtmann A, Van Aken H. et al. Tyro-sine kinase Btk regulates E-selectin-mediated inte-grin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood 2010; 115: 3118-3127.
17 Kornerup KN, Salmon GP, Pitchford SC. et al. Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration. J Appl Physiol 2010; 109: 758-767.
18 Herter JM, Rossaint J, Block H. et al. Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling. Blood 2013; 121: 2301-2310.
19 Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349.
20 Reutershan J, Ley K. Bench-to-bedside review: acute respiratory distress syndrome – how neutrophils migrate into the lung. Crit Care 2004; 08: 453-461.
21 Zarbock A, Ley K. The role of platelets in acute lung injury (ALI). Front Biosci 2009; 14: 150-158.
22 Rubenfeld GD, Caldwell E, Peabody E. et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353: 1685-1693.
23 Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 1970; 28: 596-608.
24 Hickling KG, Henderson SJ, Jackson R. Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. Intens Care Med 1990; 16: 372-377.
25 Amato MB, Barbas CS, Medeiros DM. et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338: 347-354.
26 Belperio JA, Keane MP, Lynch 3rd JP. et al. The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med 2006; 27: 350-364.
27 Estevez B, Shen B, Du X. Targeting integrin and integrin signaling in treating thrombosis. Arterioscler Thromb Vasc Biol 2015; 35: 24-29.