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Thromb Haemost 2014; 112(03): 427-431
DOI: 10.1160/TH13-11-0952
DOI: 10.1160/TH13-11-0952
Review Article
Gastrointestinal angiodysplasia and bleeding in von Willebrand disease
Weitere Informationen
Publikationsverlauf
Received:
19. November 2013
Accepted after minor revision:
08. April 2014
Publikationsdatum:
20. November 2017 (online)
Summary
Von Willebrand disease (VWD), the most common genetic bleeding disorder, is characterised by a quantitative or qualitative defect of von Willebrand factor (VWF). Patients with VWD suffer from mucocutaneous bleeding, of severity usually proportional to the degree of VWF defect. In particular, gastrointestinal bleeding associated with angiodysplasia is often a severe symptom of difficult management. This review focuses on the pathophysiology, diagnosis and treatment of VWD-associated gastrointestinal angiodysplasia and related bleeding.
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