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Thromb Haemost 2014; 112(01): 26-31
DOI: 10.1160/TH13-09-0756
Review Article
Schattauer GmbH

Implications of glycoprotein VI for theranostics

Meinrad Gawaz
1   Department of Cardiology & Cardiovascular Medicine, University of Tübingen, Germany
,
Sebastian Vogel
1   Department of Cardiology & Cardiovascular Medicine, University of Tübingen, Germany
,
Christina Pfannenberg
2   Department of Diagnostic and Interventional Radiology, University of Tübingen, Germany
,
Bernd Pichler
3   Preclinical Imaging, University of Tübingen, Germany
,
Harald Langer
1   Department of Cardiology & Cardiovascular Medicine, University of Tübingen, Germany
,
Boris Bigalke
1   Department of Cardiology & Cardiovascular Medicine, University of Tübingen, Germany
4   King’s College London, Division of Imaging Sciences and Biomedical Engineering, London, UK
› Author Affiliations Financial support: Research in the authors’ laboratory is supported by the Deutsche Forschungsgemeinschaft (KFO 274 ”Platelets – Basic Mechanisms and Translational Implications“).
Further Information

Publication History

Received: 13 September 2013

Accepted after major revision: 31 January 2014

Publication Date:
01 December 2017 (online)

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Summary

Glycoprotein VI (GPVI), a membrane glycoprotein solely expressed in platelets and megakaryocytes, plays a critical role in thrombus formation due to collagen/GPVI-mediated platelet activation and adhesion. Recent studies have shown that surface expression of GPVI on circulating platelets is enhanced in acute cardiovascular diseases such as myocardial infarction and ischaemic stroke. Increased GPVI levels are associated with poor clinical outcome and are an early indicator for imminent myocardial infarction in patients with chest pain. The soluble form of the dimeric GPVI fusion protein (sGPVI-Fc) binds with high affinity to collagen and atherosclerotic plaque tissue. Non-invasive imaging studies with radiolabelled sGPVI-Fc show specific binding activity to vascular lesions in vivo. Further, sGPVI-Fc has been developed as a new therapeutic platelet-based strategy for lesion-directed antithrombotic therapy. This review summarises the potential of GPVI for diagnostic and therapeutic options based on novel non-invasive molecular imaging modalities to ameliorate care of patients with cardiovascular diseases.

Keywords

Platelets - glycoprotein VI - biomarker - myocardial infarction - stroke - molecular imaging
 

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