Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis

Ana Luíza Gomes Quinderé; Norma Maria Barros Benevides; Federico Carbone; François Mach; Nicolas Vuilleumier; Fabrizio Montecucco

doi:10.1160/TH13-08-0712

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 111(04): 634-646
DOI: 10.1160/TH13-08-0712

Review Article

Schattauer GmbH

Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis

Ana Luíza Gomes Quinderé

¹CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil

,

Norma Maria Barros Benevides

²Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil

,

Federico Carbone

³Division of Cardiology, Foundation for Medical Researches, Department of Medical Specialties, University of Geneva, Geneva, Switzerland

⁴Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

,

François Mach

³Division of Cardiology, Foundation for Medical Researches, Department of Medical Specialties, University of Geneva, Geneva, Switzerland

,

Nicolas Vuilleumier

⁵Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland

,

Fabrizio Montecucco

⁴Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

⁵Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland

› Author Affiliations

Abstract

Summary

Atherosclerosis is the most common pathological process underlying cardiovascular diseases. Current therapies are largely focused on alleviating hyperlipidaemia and preventing thrombotic complications, but do not completely eliminate risk of suffering recurrent acute ischaemic events. Specifically targeting the inflammatory processes may help to reduce this residual risk of major adverse cardiovascular events in atherosclerotic patients. The involvement of neutrophils in the pathophysiology of atherosclerosis is an emerging field, where evidence for their causal contribution during various stages of atherosclerosis is accumulating. Therefore, the identification of neutrophils as a potential therapeutic target may offer new therapeutic perspective to reduce the current atherosclerotic burden. This narrative review highlights the expanding role of neutrophils in atherogenesis and discusses on the potential treatment targeting neutrophil-related inflammation and associated atherosclerotic plaque vulnerability.

Keywords

Atherosclerosis - inflammation - neutrophil

Full Text

References

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