Non-OO blood type influences the risk of recurrent venous thromboembolism

Esteban Gándara; Michael J. Kovacs; Susan R. Kahn; Philip S. Wells; David A. Anderson; Isabelle Chagnon; Grégoire Le Gal; Susan Solymoss; Mark Crowther; Marc Carrier; Nicole Langlois; Judy Kovacs; Julian Little Ma; Nancy Carson; Tim Ramsay; Marc A. Rodger

doi:10.1160/TH13-06-0488

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(06): 1172-1179
DOI: 10.1160/TH13-06-0488

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Non-OO blood type influences the risk of recurrent venous thromboembolism

A cohort study

Esteban Gándara

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

,

Michael J. Kovacs

³Department of Medicine, University of Western Ontario, London, Ontario, Canada

,

Susan R. Kahn

⁴Department of Medicine, McGill University, Montréal, Quebec, Canada

⁵Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montréal, Quebec, Canada

,

Philip S. Wells

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

,

David A. Anderson

⁶Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

,

Isabelle Chagnon

⁷Department of Medicine, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Quebec, Canada

,

Grégoire Le Gal

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

⁸UniversityHospital and the Department of Internal Medicine and Chest Diseases, Brest, France

,

Susan Solymoss

⁴Department of Medicine, McGill University, Montréal, Quebec, Canada

,

Mark Crowther

⁹Department of Medicine, Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada

,

Marc Carrier

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

,

Nicole Langlois

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

,

Judy Kovacs

³Department of Medicine, University of Western Ontario, London, Ontario, Canada

,

Julian Little Ma

¹⁰Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada

,

Nancy Carson

¹¹Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada

,

Tim Ramsay

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

¹⁰Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada

,

Marc A. Rodger

¹Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

²Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada

› Author Affiliations

Abstract

Summary

The role of ABO blood type as a risk factor for recurrent venous thromboembolism (VTE) in patients with a first unprovoked VTE who complete oral anticoagulation therapy is unknown. The aim of this study was to determine if non-OO blood type is a risk factor for recurrent VTE in patients with a first unprovoked VTE who completed 5–7 months of anticoagulant therapy. In an ongoing cohort study of patients with unprovoked VTE who discontinued oral anticoagulation after 5–7 months of therapy, six single nucleotide polymorphisms sites were tested to determine ABO blood type using banked DNA. The main outcome was objectively proven recurrent VTE. Mean follow-up for the cohort was 4.19 years (SD 2.16). During 1,553 patient-years of follow-up, 101 events occurred in 380 non-OO patients (6.5 events per 100 patient years; 95% CI 5.3–7.7) compared to 14 events during 560 patient years of follow-up in 129 OO patients (2.5 per 100 patient years; 95% CI 1.2–3.7), the adjusted hazard ratio was 1.98 (1.2–3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE.

Keywords

Veins - thrombosis - blood cells

Full Text

References

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