The vascular biology of macrophage migration inhibitory factor (MIF)

Yaw Asare; Martin Schmitt; Jürgen Bernhagen

doi:10.1160/TH12-11-0831

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(03): 391-398
DOI: 10.1160/TH12-11-0831

Theme Issue Article

Schattauer GmbH

The vascular biology of macrophage migration inhibitory factor (MIF)

Expression and effects in inflammation, atherogenesis and angiogenesis

Yaw Asare

¹Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany

,

Martin Schmitt

²Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

³Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands

,

Jürgen Bernhagen

¹Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany

› Author Affiliations

Abstract

Summary

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer development. More recently, MIF has been identified as an important pro-atherogenic factor. Its blockade could even aid plaque regression in advanced atherosclerosis. Promotion of atherogenic leukocyte recruitment processes has been recognised as a major underlying mechanism of MIF in vascular pathology. However, MIF’s role in vascular biology is not limited to immune cell recruitment as recent evidence also points to a role for this mediator in neo-angiogenesis / vasculogenesis by endothelial cell activation and endothelial progenitor cell recruitment. On the basis of introducing MIF’s chemokine-like functions, the current article focusses on MIF’s role in vascular biology and pathology.

Keywords

Chemokine - monocyte/macrophage - cardiovascular disease - atherosclerosis - (neo-)angiogenesis/vasculogenesis

Full Text

References

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