Thromb Haemost 2012; 108(06): 1023
DOI: 10.1160/TH12-10-0783
T&H Insights
Schattauer GmbH

Factor XIII and alternatively activated macrophages – new targets in aortic valve stenosis

Insight FXIII is also present in diseased valve leaflets and atherosclerotic lesions
Johann Wojta
1   Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received: 30 October 2012

Accepted: 30 October 2012

Publication Date:
29 November 2017 (online)

 

 
  • References

  • 1 Kapusta P, Wypasek E, Natorska J. et al. Factor XIII expression within aortic valves and its plasma activity in patients with aortic stenosis: association with severity of disease. Thromb Haemost 2012; 108: 1172-1179.
  • 2 Miller JD, Weiss RM, Heistad DD. Calcific aortic valve stenosis: methods, models, and mechansims. Circ Res 2011; 108: 1392-1412.
  • 3 Romanic AM, Arleth AJ, Willette RN. et al. Factor XIIIa cross-links lipoprotein(a) with fibrinogen and is present in human atherosclerotic lesions. Circ Res 1998; 83: 264-269.
  • 4 Wolfs IMJ, Donners MMPC, de Winther MPJ. Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation. Thromb Haemost 2011; 106: 763-771.