Biomarkers of platelet activation in acute coronary syndromes

Patrizia Ferroni; Silvia Riondino; Natale Vazzana; Nicole Santoro; Fiorella Guadagni; Giovanni Davì

doi:10.1160/TH12-08-0550

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 108(06): 1109-1123
DOI: 10.1160/TH12-08-0550

Review Article

Schattauer GmbH

Biomarkers of platelet activation in acute coronary syndromes

Patrizia Ferroni

¹Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy

,

Silvia Riondino

¹Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy

,

Natale Vazzana

²Internal Medicine and Center of Excellence on Aging, “G. D’Annunzio”University Foundation, Chieti, Italy

,

Nicole Santoro

²Internal Medicine and Center of Excellence on Aging, “G. D’Annunzio”University Foundation, Chieti, Italy

,

Fiorella Guadagni

¹Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy

,

Giovanni Davì

²Internal Medicine and Center of Excellence on Aging, “G. D’Annunzio”University Foundation, Chieti, Italy

› Author Affiliations

Abstract

Summary

The most convincing evidence for the participation of platelets in arterial thrombosis in humans comes from studies of platelet activation in patients with acute coronary syndromes (ACS) and from trials of antiplatelet drugs. Both strongly support the concept that repeated episodes of platelet activation over the thrombogenic surface of a vulnerable plaque may contribute to the risk of death from coronary causes. However, the relation of <i>in vivo</i>platelet activation and adverse clinical events to results of platelet function tests remains largely unknown. A valuable marker of <i>in vivo</i>platelet activation should be specific, unaltered by pre-analytical artefacts and reproducibly measured by easily performed methods. This article describes current biomarkers of platelet activation in ACS, reviews their advantages and disadvantages, discusses their potential pitfalls, and demonstrates emerging data supporting the positive clinical implications of monitoring in vivo platelet ac- tivation in the setting of ACS.

Keywords

Acute coronary syndromes - platelet-derived biomarkers - thromboxane - metabolites - P-selectin - CD40L

Full Text

References

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