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Thromb Haemost 2012; 108(04): 750-755
DOI: 10.1160/TH12-05-0313
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

Increased prevalence of hypertension in haemophilia patients

Dietje E. Fransen van de Putte
1   Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
,
Kathelijn Fischer
1   Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
2   Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
,
Michael Makris
3   Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK
,
R. Campbell Tait
4   West of Scotland Haemophilia and Thrombosis Centre, Royal Infirmary, Glasgow, UK
,
Peter W. Collins
5   Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK
,
Karina Meijer
6   Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Center Groningen, Groningen, The Netherlands
,
Goris Roosendaal
1   Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
,
Pratima Chowdary
7   Katharine Dormandy Haemophilia Centre and Haemostasis Unit, Royal Free Hospital, London, UK
,
Roger E. G. Schutgens
1   Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
,
Eveline P. Mauser-Bunschoten
1   Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
› Author Affiliations Financial support: This study was supported by an unrestricted grant from CSL Behring to DEFvdP.
Further Information

Publication History

Received: 14 May 2012

Accepted after minor revision: 04 August 2012

Publication Date:
29 November 2017 (online)

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Summary

An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and 315 UK haemophilia patients aged 30 years or older were analysed and compared with the general age-matched male population. Mean values of up to three BP measurements were used when available. Hypertension was defined as BP over 140/90 mmHg and/or the use of antihypertensive medication. A total of 49% of patients had severe haemophilia. Mean age was 49.8 years. The prevalence of hypertension was significantly higher in haemophilia patients (49%, 95% confidence interval [CI] 45–53) than in the general population (40%, 95% CI 37–43). The prevalence of hypertension was higher in patients with severe haemophilia than in those with non-severe disease, but similar across haemophilia types and in Dutch and UK patients. Multiple BP measurements were available for 70%.The prevalence of hypertension was similar in patients with multiple BP measurements and the complete cohort. Hypertension was not significantly associated with renal function, a history of renal bleeding or with infection with hepatitis C or HIV, but it was associated with overweight/obesity and age. In conclusion, the prevalence of hypertension is higher in haemophilia patients than in the general population. The cause of this increased prevalence is unknown. Blood pressure measurements should be part of standard care in haemophilia patients aged 30 years or older.

Keywords

Haemophilia - hypertension
 

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