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Thromb Haemost 2012; 107(03): 545-551
DOI: 10.1160/TH11-08-05563
Wound Healing and Inflammation/Infection
Schattauer GmbH

Reduced bone mineral density in patients with haemophilia A and B in Northern Greece

Panagiotis Anagnostis
1   Department of Endocrinology, Hippokration Hospital, Thessaloniki, Greece
,
Sofia Vakalopoulou
2   Division of Haematology, 2nd Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
,
Aristidis Slavakis
3   Department of biochemistry, Hormone Assay Laboratory, Hippokration Hospital, Thessaloniki, Greece
,
Maria Charizopoulou
4   Department of Psychology, School of Philosophy, Aristotle University, Thessaloniki, Greece
,
Eirini Kazantzidou
5   Radiology Department, Hippokration Hospital, Thessaloniki, Greece
,
Tania Chrysopoulou
5   Radiology Department, Hippokration Hospital, Thessaloniki, Greece
,
Timoleon-Achilleas Vyzantiadis
6   1st Department of Microbiology, Medical School, Aristotle University, Thessaloniki, Greece
,
Eleni Moka
2   Division of Haematology, 2nd Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
,
Alexandra Agapidou
2   Division of Haematology, 2nd Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
,
Vassilia Garipidou
2   Division of Haematology, 2nd Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

Received: 17 August 2012

Accepted after minor revision: 16 February 2011

Publication Date:
22 November 2017 (online)

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Summary

Haemophilia A and B has been associated with increased prevalence of low bone mass (67–86%). The aim of this study was to estimate the prevalence of bone disease in haemophiliacs and its association with potential risk factors. Adult patients with haemophilia A and B followed-up in the Haemophilia Centre of Northern Greece were included. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) in lumbar spine (LS), femoral neck (FN), total hip (TH) and great trochanter (GT). One-hundred four male patients (aged 45.8 ± 15.1 years) and 50 controls (aged 44.9 ± 12.8 years) were screened. Low BMD was diagnosed in 28 patients (26.9%) and 10 controls (20%) (p=0.0001). Patients had lower BMD in TH (p=0.007), FN (p=0.029) and GT (p=0.008) than controls, without differences in LS. BMD was positively associated with the severity of haemophilia, history of herpes virus C or human immunodeficiency virus and level of physical activity, and negatively with the level of arthropathy. In multiple-regression analysis, only the level of physical activity and 25-hydroxyvitamin D [25(OH)D] significantly predicted BMD. Half of the patients had vitamin D deficiency. In conclusion, our study showed increased prevalence of low BMD in haemophiliacs. The levels of physical activity and 25(OH)D independently predicted low BMD.

Keywords

Haemophilia - osteoporosis - osteopenia - bone mass
 

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