Intravital imaging of phagocyte recruitment

Remco T. A. Megens; Klaus Kemmerich; Juergen Pyta; Christian Weber; Oliver Soehnlein

doi:10.1160/TH10-11-0735

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 105(05): 802-810
DOI: 10.1160/TH10-11-0735

Theme Issue Article

Schattauer GmbH

Intravital imaging of phagocyte recruitment

Remco T. A. Megens

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany

²Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Germany

³Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

,

Klaus Kemmerich

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany

³Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

,

Juergen Pyta

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany

,

Christian Weber

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany

³Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

⁴Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

,

Oliver Soehnlein

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany

³Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

⁴Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

› Author Affiliations

Abstract

Summary

Extravasation of neutrophils and monocytes is a hallmark event in acute and chronic inflammation. Owing to recent improvements in optical imaging techniques, the classical leukocyte extravasation cascade has been refined with intermediate steps being added. Further studies have shown tissue specific leukocyte recruitment patterns, thus allowing for more selective targeting. Here we focus on recent advances in intravital imaging of leukocyte recruitment by means of optical imaging techniques and emphasise the translation thereof into tissue-specific recruitment to the lungs, the liver and large arteries.

Keywords

Imaging - leukocyte trafficking / recruitment - cell migration - inflammation

Full Text

References

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